利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

14 条记录 (耗时 0.02 秒)

    Method of making pharmaceutical using electrostatic chuck
    5.
    发明授权
    Method of making pharmaceutical using electrostatic chuck 失效
    使用静电吸盘制造药物的方法

    公开(公告)号：US5846595A

    公开(公告)日：1998-12-08

    申请号：US630050

    申请日：1996-04-09

    申请人： Hoi Cheong Steve Sun ,  Timothy Allen Pletcher

    发明人： Hoi Cheong Steve Sun ,  Timothy Allen Pletcher

    IPC分类号： A61K9/20 ,  A61K9/28 ,  B05B5/08 ,  H02N13/00 ,  B05D1/04 ,  A61J3/02 ,  B05D1/06

    CPC分类号： H02N13/00 ,  A61K9/2086 ,  A61K9/2893 ,  B05B5/084 ,  B05B5/087 ,  B01J2219/00468

    摘要： The present invention is directed to electrostatic chucks, methods for their use, the electrostatic deposition of particles on an objects, and the objects themselves that have been subjected to electrostatic deposition. In one aspect, the present invention provides an electrostatic chuck for electrostatically attracting an object or objects wherein the object is used in chemical or pharmaceutical assaying or manufacturing, and optionally wherein the object is less than or equal to one millimeter in average width or diameter. The objects can be pharmaceutical substrates, for example, such as a pharmaceutical tablet. Additional embodiments of the invention provide chucks and their use to electrostatically attract particles, such as a pharmaceutically active ingredient, to a substrate, such as a tablet. In one aspect, the electrostatic chuck comprises a floating electrode, and is used to selectively attract particles to a substrate above the floating electrode, thereby providing for charge imaging for the deposition of particles in a selected image. Additionally, the invention provides an electrostatic chuck comprising a sensing electrode for sensing the number of particles attracted to the chuck, thereby providing for deposition of an accurate amount of particles. Furthermore, the present invention provides objects having selected areas in which particles are applied to the object via electrostatic means.

    摘要翻译： 本发明涉及静电卡盘，其使用方法，物体上的颗粒的静电沉积以及已经经受静电沉积的物体本身。 一方面，本发明提供一种用于静电吸引物体的静电吸盘，其中所述物体用于化学或药物测定或制造，并且任选地其中所述物体的平均宽度或直径小于或等于1毫米。 物体可以是药物底物，例如药物片剂。 本发明的另外的实施方案提供了卡盘及其用于静电吸引诸如药物活性成分的颗粒到底物例如片剂。 一方面，静电卡盘包括浮动电极，并且用于选择性地将颗粒吸引到浮动电极上方的衬底上，从而为选定图像中的颗粒沉积提供电荷成像。 此外，本发明提供了一种静电卡盘，其包括感测电极，用于感测吸引到卡盘的颗粒数量，从而提供精确量的颗粒的沉积。 此外，本发明提供了具有通过静电装置将颗粒施加到物体的选择区域的物体。

    Electrostatic chucks and a particle deposition apparatus therefor
    6.
    发明授权
    Electrostatic chucks and a particle deposition apparatus therefor 失效
    静电吸盘及其颗粒沉积设备

    公开(公告)号：US06294024B1

    公开(公告)日：2001-09-25

    申请号：US09175287

    申请日：1998-10-20

    申请人： Hoi Cheong Steve Sun ,  Timothy Allen Pletcher

    发明人： Hoi Cheong Steve Sun ,  Timothy Allen Pletcher

    IPC分类号： B05C1904

    CPC分类号： B05B5/087 ,  A61K9/2086 ,  A61K9/2893 ,  B01J2219/00468 ,  B05B5/08 ,  B05B5/082 ,  H02N13/00 ,  Y10T428/2991

    摘要： The present invention is directed to electrostatic chucks, methods for their use, the electrostatic deposition of objects, such as particles in a dry powder, onto recipient substrates, and the recipient substrates themselves that have been subjected to electrostatic deposition. In one aspect, the present invention provides an electrostatic chuck for electrostatically attracting an object or objects wherein the object is used in chemical or pharmaceutical assaying or manufacturing. The objects can be pharmaceutical substrates, for example, such as a pharmaceutical tablet. Additional embodiments of the invention provide chucks and their use to electrostatically attract particles, such as a pharmaceutically active ingredient, to a substrate, such as a tablet. In one aspect, the electrostatic chuck comprises a floating electrode, and is used to selectively attract particles to a substrate above the floating electrode, thereby providing for charge imaging for the deposition of particles in a selected image. Additionally, the invention provides comprising a sensing electrode, optionally for use with an electrostatic chuck, for sensing the number of particles attracted to the objects on the chuck or other substrate, thereby providing for deposition of an accurate amount of particles. Furthermore, the present invention provides objects having selected areas in which particles are applied to the object via electrostatic means.

    摘要翻译： 本发明涉及静电卡盘，它们的使用方法，诸如干粉末中的物体的静电沉积到受体基底上，以及已经经过静电沉积的受体底物本身。 一方面，本发明提供一种用于静电吸引物体的静电吸盘，其中该物体用于化学或药物测定或制造。 物体可以是药物底物，例如药物片剂。 本发明的另外的实施方案提供了卡盘及其用于静电吸引诸如药物活性成分的颗粒到底物例如片剂。 一方面，静电卡盘包括浮动电极，并且用于选择性地将颗粒吸引到浮动电极上方的衬底上，从而为选定图像中的颗粒沉积提供电荷成像。 另外，本发明提供了包括感测电极，可选地与静电卡盘一起使用，用于感测吸附到卡盘或其它基底上的物体的颗粒的数量，从而提供精确量的颗粒的沉积。 此外，本发明提供了具有通过静电装置将颗粒施加到物体的选择区域的物体。

    Acoustic dispenser
    7.
    发明授权
    Acoustic dispenser 失效
    声音分配器

    公开(公告)号：US5753302A

    公开(公告)日：1998-05-19

    申请号：US661211

    申请日：1996-06-10

    申请人： Hoi Cheong Steve Sun ,  Pabitra Datta ,  William Yat Chung Chiang ,  Howard Christopher Rivenburg ,  Bawa Singh ,  Dominic S. Rosati ,  James Regis Matey

    发明人： Hoi Cheong Steve Sun ,  Pabitra Datta ,  William Yat Chung Chiang ,  Howard Christopher Rivenburg ,  Bawa Singh ,  Dominic S. Rosati ,  James Regis Matey

    IPC分类号： A61K41/00 ,  B05B5/047 ,  B05B17/06 ,  B05D1/06 ,  B05B7/00 ,  B05C3/05 ,  B05D1/12

    CPC分类号： A61K41/00 ,  A61K41/0014 ,  B05B17/06 ,  B05B5/047 ,  B01J2219/00468

    摘要： The present invention provides an acoustic dispenser for propelling objects toward a substrate, together with methods of use of the dispenser. The acoustic dispenser uses a source of acoustic vibration and a membrane for the application of acoustic vibration wherein the objects are propelled from the membrane to a substrate. The acoustic dispenser and the methods of the invention can be used with numerous types of objects. In some embodiments, the objects are particles in a dry powder, which can include, for example, a pharmaceutically active ingredient. In other embodiments, the objects are beads, which preferably have an average diameter of about 100 to about 300 microns. Additionally, the acoustic dispenser can be used with more than one type of object, for example, two types of objects such as beads and dry powder. In some instances, the acoustic dispenser further comprises a membrane for separating one type of object from the other based on size, whereby one type of object is separated from the other prior to deposition.

    摘要翻译： 本发明提供一种用于将物体推向基板的声学分配器，以及分配器的使用方法。 声学分配器使用声振动源和用于施加声振动的膜，其中物体从膜推进到基底。 声音分配器和本发明的方法可以与许多类型的物体一起使用。 在一些实施方案中，物体是干粉末中的颗粒，其可以包括例如药物活性成分。 在其它实施方案中，物体是珠，其优选具有约100至约300微米的平均直径。 此外，声音分配器可以与多于一种类型的物体一起使用，例如两种类型的物体，例如珠粒和干粉。 在一些情况下，声音分配器还包括用于基于尺寸将一种类型的物体与另一种物体分离的膜，由此在沉积之前一种类型的物体与另一种物体分离。

    Inhaler apparatus with an electronic means for enhanced release of dry powders
    9.
    发明授权
    Inhaler apparatus with an electronic means for enhanced release of dry powders 失效
    具有电子装置的吸入装置，用于增强干粉的释放

    公开(公告)号：US5857456A

    公开(公告)日：1999-01-12

    申请号：US661212

    申请日：1996-06-10

    申请人： Hoi Cheong Steve Sun ,  Bawa Singh ,  Howard Christopher Rivenburg ,  Pabitra Datta ,  Nitin Vithabhi Desai

    发明人： Hoi Cheong Steve Sun ,  Bawa Singh ,  Howard Christopher Rivenburg ,  Pabitra Datta ,  Nitin Vithabhi Desai

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0045 ,  A61M15/0051 ,  A61M15/0055 ,  A61M2205/0233

    摘要： The present invention is directed, in part, to an inhaler apparatus with a substrate having medicament deposited thereon, the substrate being configured for electronic release of the medicament. In preferred embodiments, the inhaler comprises a conductive layer and a dielectric layer thereon. In preferred embodiments, the inhaler further comprises a second conductive layer positioned above the substrate without having contact with the substrate. In certain preferred embodiments, the voltage source is connected to the conductive layer in the substrate and the second conductive layer above the substrate. In other preferred embodiments, the inhaler apparatus further comprises a third conductive layer positioned below the substrate, and the voltage source is preferably connected to the second conductive layer above the substrate and the third conductive layer below the substrateIn another aspect, the present invention provides a method for dispensing a medicant from an inhaler, comprising: (a) providing an inhaler with a substrate having a medicant deposited thereon, the substrate comprising a conductive layer and a dielectric layer and a voltage source connected to said conductive layer; and (b) actuating the voltage source.

    摘要翻译： 本发明部分地涉及具有沉积有药剂的基底的吸入器装置，该基底被配置为电子释放药物。 在优选实施例中，吸入器在其上包括导电层和介电层。 在优选实施例中，吸入器还包括位于衬底上方的第二导电层，而不与衬底接触。 在某些优选实施例中，电压源连接到衬底中的导电层和衬底上方的第二导电层。 在其它优选实施例中，吸入器装置还包括位于衬底下方的第三导电层，并且电压源优选地连接到衬底上方的第二导电层和衬底下方的第三导电层。在另一方面，本发明提供 一种从吸入器分配药物的方法，包括：（a）为吸入器提供具有沉积在其上的药物的基底，所述基底包括导电层和电介质层以及连接到所述导电层的电压源; 和（b）致动电压源。

    Chucks and methods for positioning multiple objects on a substrate
    10.
    发明授权
    Chucks and methods for positioning multiple objects on a substrate 失效
    用于将多个物体定位在基板上的卡盘和方法

    公开(公告)号：US5788814A

    公开(公告)日：1998-08-04

    申请号：US630012

    申请日：1996-04-09

    申请人： Hoi Cheong Steve Sun ,  Christina Marie Knoedler

    发明人： Hoi Cheong Steve Sun ,  Christina Marie Knoedler

    IPC分类号： A61K9/20 ,  B01J19/00 ,  B05B5/08 ,  B23B20060101 ,  B23B5/22 ,  C25D17/04 ,  B23B5/34 ,  C25D17/06

    CPC分类号： B05B5/087 ,  A61K9/2072 ,  A61K9/2095 ,  B01J19/0046 ,  B05B5/08 ,  B05B5/084 ,  B01J2219/00459 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00648 ,  B01J2219/00659 ,  Y10S118/02 ,  Y10T279/11 ,  Y10T279/23

    摘要： The present invention relates to chucks and methods for positioning multiple objects, optionally for transport onto a recipient substrate. Instead of using conventional clamps that employ mechanical force, the present invention is directed to the use of a non-mechanical force such as negative pressure in a vacuum chuck, or static electricity in an electrostatic chuck as the force applied to the objects held by the chuck. Further, the chuck has a layer for holding the objects which are optionally subsequently transferred to a recipient substrate, the layer having a configuration substantially corresponding to the configuration of the recipient substrate. In certain aspects, the present invention is directed to a chuck for positioning objects with an average width or diameter less than or equal to one millimeter, and a thickness preferably less than about 3 millimeters, such as beads used in the chemical industry. In another aspect, the invention is directed to methods which involve the use of chucks, including methods for attracting an object or multiple objects, methods for positioning objects, methods for transporting objects, preferably substantially simultaneously, and methods of chemical manufacturing using the chucks.

    摘要翻译： 本发明涉及用于定位多个物体的卡盘和方法，可选地用于运送到接收器基底上。 代替使用采用机械力的常规夹具，本发明涉及在真空卡盘中使用诸如负压的非机械力或静电卡盘中的静电作为施加到由 卡盘 此外，卡盘具有用于保持任选地随后转移到接收器基底的物体的层，该层具有基本上对应于接受基底的构造的构造。 在某些方面，本发明涉及用于定位平均宽度或直径小于或等于1毫米，厚度优选小于约3毫米的物体的卡盘，例如化学工业中使用的珠子。 在另一方面，本发明涉及涉及使用卡盘的方法，包括用于吸引物体或多个物体的方法，用于定位物体的方法，优选基本上同时运送物体的方法以及使用卡盘的化学制造方法。