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1.Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same 有权
标题翻译: 制备用于治疗和诊断应用的多价构建体的方法及其制备方法公开(公告)号:US07666979B2
公开(公告)日:2010-02-23
申请号:US10916155
申请日:2004-08-11
CPC分类号: A61K51/088 , A61K47/60 , A61K47/64 , A61K49/0043 , A61K49/0056 , A61K49/223 , B82Y5/00 , C07K7/08 , C07K7/64
摘要: Methods for the preparation of multivalent constructs for therapeutic and diagnostic applications are provided. More specifically, novel methods for preparing multivalent constructs comprising the formula A-B-C-D-E-B′-F for therapeutic and diagnostic applications are provided which use a novel linker D comprising, in various embodiments, a dicarboxylic acid derivative such as, e.g., a glutaric acid bis N-hydroxysuccinimidyl ester or a derivative thereof; or a diamine derivative.The remaining components in the multivalent construct A-B-C-D-E-B′-F are defined as follows: A is a first peptide, B is a first branching group, C is an optional first spacer, E is an optional second spacer which may be the same as or different from said first spacer C, B′ is an optional second branching group which may be the same as or different from said first branching group B, and F is a second peptide which may be the same as or different from said first peptide A.
摘要翻译: 提供了用于治疗和诊断应用的多价构建体的制备方法。 更具体地,提供了用于制备包含用于治疗和诊断应用的式ABCDEB'-F的多价构建体的新方法,其使用新的接头D,其在各种实施方案中包括二羧酸衍生物,例如戊二酸双-N- 羟基琥珀酰亚胺酯或其衍生物; 或二胺衍生物。 多价构建体ABCDEB'-F中的其余组分定义如下:A是第一个肽,B是第一个支化基团,C是可选的第一个间隔基,E是可选的第二间隔基,其可以相同或不同 从所述第一间隔物C中,B'是任选的第二支化基团,其可以与所述第一支化基团B相同或不同,F是可以与所述第一肽A相同或不同的第二肽。
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2.KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY 有权
标题翻译: KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用公开(公告)号:US20100003195A1
公开(公告)日:2010-01-07
申请号:US12480578
申请日:2009-06-08
申请人: Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
发明人: Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
IPC分类号: A61K49/22
CPC分类号: A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
摘要: The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译: 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽,肽二聚体和多聚体复合物,其具有各种用途,无论何处治疗,检测,分离或定位血管发生都是有利的。 特别公开的是能够以高亲和力(例如具有KD <1μM)结合KDR或VEGF / KDR复合物的合成,分离的多肽,以及包含这些多肽的二聚体和多聚体构建体。
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公开(公告)号:US07211240B2
公开(公告)日:2007-05-01
申请号:US10379287
申请日:2003-03-03
申请人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sybille Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sybille Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron Sato , Sharon Michele Walker , Daniel T. Dransfield
IPC分类号: A61K49/00
摘要: The invention provides compositions and methods for therapeutic and diagnostic applications.
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公开(公告)号:US07854919B2
公开(公告)日:2010-12-21
申请号:US11624894
申请日:2007-01-19
申请人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron Sato , Sharon Michele Walker , Daniel T. Dransfield , Ajay Shrivastava
发明人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron Sato , Sharon Michele Walker , Daniel T. Dransfield , Ajay Shrivastava
摘要: The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译: 本发明提供用于治疗和诊断应用的组合物和方法。
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公开(公告)号:US07261876B2
公开(公告)日:2007-08-28
申请号:US10661032
申请日:2003-09-11
申请人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron Sato , Sharon Michele Walker , Daniel T. Dransfield
IPC分类号: A61K49/00
CPC分类号: A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
摘要: The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译: 本发明提供用于治疗和诊断应用的组合物和方法。
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6.KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY 有权
标题翻译: KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用公开(公告)号:US20110097275A1
公开(公告)日:2011-04-28
申请号:US12898119
申请日:2010-10-05
申请人: Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan
发明人: Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan
CPC分类号: A61K49/221 , A61K38/00 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/58
摘要: The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译: 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽,肽二聚体和多聚体复合物,其具有各种用途,无论何处治疗,检测,分离或定位血管发生都是有利的。 特别公开的是能够以高亲和力(例如具有KD <1μM)结合KDR或VEGF / KDR复合物的合成,分离的多肽,以及包含这些多肽,特别是造影剂的二聚体和多聚体构建体。 还提供了使用本发明的造影剂监测和评估与血管生成或内皮细胞过度增殖相关的疾病(例如癌症)的治疗方案的治疗有效性的方法。
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7.KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy 有权
标题翻译: KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用公开(公告)号:US08642010B2
公开(公告)日:2014-02-04
申请号:US12480578
申请日:2009-06-08
申请人: Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Feng Yan , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
发明人: Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Feng Yan , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
CPC分类号: A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
摘要: The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译: 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽,肽二聚体和多聚体复合物,其具有各种用途,无论何处治疗,检测,分离或定位血管发生都是有利的。 特别公开的是能够以高亲和力(例如具有KD <1μM)结合KDR或VEGF / KDR复合物的合成,分离的多肽,以及包含这些多肽的二聚体和多聚体构建体。
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公开(公告)号:US08663603B2
公开(公告)日:2014-03-04
申请号:US12888736
申请日:2010-09-23
申请人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
IPC分类号: A61B8/00
摘要: The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译: 本发明提供用于治疗和诊断应用的组合物和方法。
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9.KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy 有权
标题翻译: KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用公开(公告)号:US08623822B2
公开(公告)日:2014-01-07
申请号:US12898119
申请日:2010-10-05
申请人: Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan
发明人: Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan
IPC分类号: C07K14/00
CPC分类号: A61K49/221 , A61K38/00 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/58
摘要: The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译: 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽,肽二聚体和多聚体复合物,其具有各种用途,无论何处治疗,检测,分离或定位血管发生都是有利的。 特别公开的是能够以高亲和力(例如具有KD <1μM)结合KDR或VEGF / KDR复合物的合成,分离的多肽,以及包含这些多肽,特别是造影剂的二聚体和多聚体构建体。 还提供了使用本发明的造影剂监测和评估与血管生成或内皮细胞过度增殖相关的疾病(例如癌症)的治疗方案的治疗有效性的方法。
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公开(公告)号:US07910088B2
公开(公告)日:2011-03-22
申请号:US11688968
申请日:2007-03-21
申请人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield , Feng Yan
发明人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield , Feng Yan
IPC分类号: A61B8/00
CPC分类号: A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
摘要: The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译: 本发明提供用于治疗和诊断应用的组合物和方法。
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