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公开(公告)号:US09505730B2
公开(公告)日:2016-11-29
申请号:US14351006
申请日:2012-10-08
申请人: Hong Shen , Jason M. Cox , Christine Yang , Zhicai Wu
发明人: Hong Shen , Jason M. Cox , Christine Yang , Zhicai Wu
IPC分类号: C07D263/44 , C07D413/12 , C07D413/06 , A61K31/422 , A61K31/4439 , A61K31/4725 , C07D401/06 , A61K31/421
CPC分类号: C07D263/44 , A61K31/421 , A61K31/422 , A61K31/4439 , A61K31/4725 , C07D401/06 , C07D413/06 , C07D413/12
摘要: The present invention is directed to compounds of the Formula I as well as pharmaceutically acceptable salts thereof, that are potentially useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula I, to their possible use in the treatment of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula I.
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公开(公告)号:US09193717B2
公开(公告)日:2015-11-24
申请号:US14350888
申请日:2012-10-08
申请人: Hong Shen , Christine Yang , Jason M. Cox , Kun Liu
发明人: Hong Shen , Christine Yang , Jason M. Cox , Kun Liu
IPC分类号: C07D413/04 , C07D413/14 , C07D403/04 , A61K31/422 , A61K31/4439 , A61K31/506 , A61K31/5377
CPC分类号: C07D413/04 , A61K31/422 , A61K31/4439 , A61K31/506 , A61K31/5377 , C07D403/04 , C07D413/14
摘要: The present invention is directed to compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, that are aldosterone receptor antagonists which might be useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula (I), to their possible use for the treatment of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula (I).
摘要翻译: 本发明涉及可用于治疗醛固酮介导的疾病的醛固酮受体拮抗剂的式(I)化合物及其药学上可接受的盐。 本发明还涉及制备式(I)化合物,其可能用于治疗上述疾病和为此目的制备药物的方法,以及包含式(I)化合物的药物组合物。
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公开(公告)号:US08933113B2
公开(公告)日:2015-01-13
申请号:US13979875
申请日:2012-01-19
申请人: Alejandro Crespo , Ping Lan , Rudrajit Mal , Anthony Ogawa , Hong Shen , Peter J. Sinclair , Zhongxiang Sun , Ellen K. Vande Bunte , Zhicai Wu , Kun Liu , Robert J. DeVita , Dong-Ming Shen , Min Shu , John Qiang Tan , Changhe Qi , Yuguang Wang , Richard Beresis
发明人: Alejandro Crespo , Ping Lan , Rudrajit Mal , Anthony Ogawa , Hong Shen , Peter J. Sinclair , Zhongxiang Sun , Ellen K. Vande Bunte , Zhicai Wu , Kun Liu , Robert J. DeVita , Dong-Ming Shen , Min Shu , John Qiang Tan , Changhe Qi , Yuguang Wang , Richard Beresis
IPC分类号: A61K31/416 , C07D231/56 , A61K31/405 , A61K31/404 , C07D403/06 , C07D209/08 , C07D209/10 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K45/06 , C07D413/06
CPC分类号: C07D413/06 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/416 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K45/06 , C07D209/08 , C07D209/10 , C07D231/56 , C07D403/04 , C07D403/06 , C07D405/06
摘要: Disclosed are the compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, which are useful for treating aldosterone-mediated diseases. The processes for preparing compounds of the Formula (I), the use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and the pharmaceutical compositions which comprise compounds of the formula (I) are disclosed too.
摘要翻译: 公开了式(I)化合物及其药学上可接受的盐,其可用于治疗醛固酮介导的疾病。 还公开了制备式(I)化合物,用于治疗和预防上述疾病和用于制备用于此目的的药物的方法和包含式(I)化合物的药物组合物。
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公开(公告)号:US20130331419A1
公开(公告)日:2013-12-12
申请号:US13979875
申请日:2012-01-19
申请人: Alejandro Crespo , Ping Lan , Rudrajit Mal , Anthony Ogawa , Hong Shen , Peter J. Sinclair , Zhongxiang Sun , Ellen K. Vande Bunte , Zhicai Wu , Kun Liu , Robert J. DeVita , Dong-Ming Shen , Min Shu , John Qiang Tan , Changhe Qi , Yuguang Wang , Richard Beresis
发明人: Alejandro Crespo , Ping Lan , Rudrajit Mal , Anthony Ogawa , Hong Shen , Peter J. Sinclair , Zhongxiang Sun , Ellen K. Vande Bunte , Zhicai Wu , Kun Liu , Robert J. DeVita , Dong-Ming Shen , Min Shu , John Qiang Tan , Changhe Qi , Yuguang Wang , Richard Beresis
IPC分类号: C07D209/08 , A61K45/06 , C07D231/56 , A61K31/416 , A61K31/422 , C07D413/06 , A61K31/4245 , C07D403/06 , A61K31/4196 , A61K31/405 , A61K31/404
CPC分类号: C07D413/06 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/416 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K45/06 , C07D209/08 , C07D209/10 , C07D231/56 , C07D403/04 , C07D403/06 , C07D405/06
摘要: Disclosed are the compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, which are useful for treating aldosterone-mediated diseases. The processes for preparing compounds of the Formula (I), the use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and the pharmaceutical compositions which comprise compounds of the formula (I) are disclosed too.
摘要翻译: 公开了式(I)化合物及其药学上可接受的盐,其可用于治疗醛固酮介导的疾病。 还公开了制备式(I)化合物,用于治疗和预防上述疾病和用于制备用于此目的的药物的方法和包含式(I)化合物的药物组合物。
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公开(公告)号:US20140275133A1
公开(公告)日:2014-09-18
申请号:US14350930
申请日:2012-10-08
申请人: Hong Shen , Jason M. Cox , Hong Dong Chu
发明人: Hong Shen , Jason M. Cox , Hong Dong Chu
IPC分类号: C07D413/04 , C07D413/14 , A61K31/4245 , A61K31/422 , A61K31/506 , A61K31/454
CPC分类号: C07D413/04 , A61K31/422 , A61K31/4245 , A61K31/4439 , A61K31/454 , A61K31/506 , C07D263/44 , C07D413/14
摘要: The present invention is directed to compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof that are possible useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula (I), to their possible use for the treatment of the above mentioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula (I).
摘要翻译: 本发明涉及可用于治疗醛固酮介导的疾病的式(I)化合物及其药学上可接受的盐。 本发明还涉及制备式(I)化合物,其可能用于治疗上述疾病和为此目的制备药物的方法,以及包含式(I)化合物的药物组合物。
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公开(公告)号:US20140336224A1
公开(公告)日:2014-11-13
申请号:US14110441
申请日:2012-10-18
申请人: Ping Lan , Kun Liu , Anthony Ogawa , Hong Shen , Christine Yang , Yuguang Wang , Richard Beresis , Changhe Qi
发明人: Ping Lan , Kun Liu , Anthony Ogawa , Hong Shen , Christine Yang , Yuguang Wang , Richard Beresis , Changhe Qi
IPC分类号: C07D413/06 , A61K31/4245 , C07D401/04 , A61K31/4439 , C07D231/56 , A61K31/416
CPC分类号: C07D413/06 , A61K31/416 , A61K31/4245 , A61K31/4439 , C07D231/56 , C07D401/04
摘要: Compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, that may be useful for treating aldosterone-mediated diseases are disclosed. Processes for preparing compounds of the Formula (I), use of the compounds for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and pharmaceutical compositions which comprise compounds of the Formula (I) are disclosed.
摘要翻译: 公开了可用于治疗醛固酮介导的疾病的式(I)化合物及其药学上可接受的盐。 公开了制备式(I)化合物的方法,该化合物用于治疗和预防上述疾病和用于制备用于此目的的药物的用途,以及包含式(I)化合物的药物组合物。
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公开(公告)号:US09487506B2
公开(公告)日:2016-11-08
申请号:US14110441
申请日:2012-04-11
申请人: Ping Lan , Kun Liu , Anthony Ogawa , Hong Shen , Christine Yang , Yuguang Wang , Richard Beresis , Changhe Qi
发明人: Ping Lan , Kun Liu , Anthony Ogawa , Hong Shen , Christine Yang , Yuguang Wang , Richard Beresis , Changhe Qi
IPC分类号: C07D413/06 , A61K31/4245 , C07D401/04 , A61K31/4439 , C07D231/56 , A61K31/416
CPC分类号: C07D413/06 , A61K31/416 , A61K31/4245 , A61K31/4439 , C07D231/56 , C07D401/04
摘要: Compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, that may be useful for treating aldosterone-mediated diseases are disclosed. Processes for preparing compounds of the Formula (I), use of the compounds for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and pharmaceutical compositions which comprise compounds of the Formula (I) are disclosed.
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公开(公告)号:US09284301B2
公开(公告)日:2016-03-15
申请号:US13636760
申请日:2011-03-22
申请人: Darby Schmidt , Subharekha Raghavan , John Stelmach , Jian Guo , Jonathan Groeper , Linda Brockunier , Keith Rosauer , Hong Shen , Rui Liang , Fa-Xiang Ding
发明人: Darby Schmidt , Subharekha Raghavan , John Stelmach , Jian Guo , Jonathan Groeper , Linda Brockunier , Keith Rosauer , Hong Shen , Rui Liang , Fa-Xiang Ding
IPC分类号: C07D403/14 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
CPC分类号: C07D403/14 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要: The invention relates to compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, which are soluble guanylate cyclase activators. The compounds are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.
摘要翻译: 本发明涉及具有式(I)结构的化合物及其药学上可接受的盐,它们是可溶性鸟苷酸环化酶活化剂。 这些化合物能够调节人体的环鸟苷酸(“cGMP”)的产生,并且通常适用于治疗和预防与受干扰的cGMP平衡有关的疾病。 该化合物可用于治疗或预防心血管疾病,内皮功能障碍,舒张功能障碍,动脉粥样硬化,高血压,肺动脉高压,心绞痛,血栓形成,再狭窄,心肌梗死,中风,心功能不全,肺性高血压,勃起功能障碍,支气管哮喘,慢性 肾功能不全,糖尿病或肝硬化。
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公开(公告)号:US20130193573A1
公开(公告)日:2013-08-01
申请号:US13360489
申请日:2012-01-27
申请人: Hong Shen
发明人: Hong Shen
CPC分类号: H01L29/452 , H01L21/76898 , H01L21/8252 , H01L24/45 , H01L24/48 , H01L24/83 , H01L24/97 , H01L27/02 , H01L29/20 , H01L33/12 , H01L2224/0401 , H01L2224/04026 , H01L2224/05647 , H01L2224/05655 , H01L2224/05664 , H01L2224/13101 , H01L2224/29294 , H01L2224/293 , H01L2224/32225 , H01L2224/32245 , H01L2224/45124 , H01L2224/45144 , H01L2224/45147 , H01L2224/48091 , H01L2224/48227 , H01L2224/48247 , H01L2224/48647 , H01L2224/48655 , H01L2224/48664 , H01L2224/48747 , H01L2224/48755 , H01L2224/48764 , H01L2224/48847 , H01L2224/48855 , H01L2224/48864 , H01L2224/73265 , H01L2224/81815 , H01L2224/83192 , H01L2224/83815 , H01L2224/85205 , H01L2224/85207 , H01L2224/97 , H01L2924/00011 , H01L2924/10329 , H01L2924/12042 , H01L2924/1305 , H01L2924/15311 , H01L2924/15313 , H01L2924/181 , H01L2924/00014 , H01L2924/014 , H01L2224/83 , H01L2924/00 , H01L2224/83205 , H01L2924/00012
摘要: Systems, apparatuses, and methods related to the design, fabrication, and manufacture of gallium arsenide (GaAs) integrated circuits are disclosed. Copper can be used as the contact material for a GaAs integrated circuit. Metallization of the wafer and through-wafer vias can be achieved through copper plating processes disclosed herein. To avoid warpage, the tensile stress of a conductive layer deposited onto a GaAs substrate can be offset by depositing a compensating layer having negative stress over the GaAs substrate. GaAs integrated circuits can be singulated, packaged, and incorporated into various electronic devices.
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公开(公告)号:US20130012511A1
公开(公告)日:2013-01-10
申请号:US13636760
申请日:2011-03-22
申请人: Darby Schmidt , Subharekha Raghavan , John Stelmach , Jian Guo , Jonathan Groeper , Linda Brockunier , Keith Rosauer , Hong Shen , Rui Liang , Fa-Xiang Ding
发明人: Darby Schmidt , Subharekha Raghavan , John Stelmach , Jian Guo , Jonathan Groeper , Linda Brockunier , Keith Rosauer , Hong Shen , Rui Liang , Fa-Xiang Ding
IPC分类号: C07D403/14 , A61K31/506 , C07D471/04 , C07D401/14 , C07D413/14 , A61K31/5377 , C07D417/14 , C07D403/04 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/04 , A61P7/02 , A61P11/00 , A61P15/00 , A61P11/06 , A61P13/12 , A61P3/10 , A61P1/16 , A61P9/08 , A61P7/10 , A61P3/00 , A61P3/06 , C07D487/04
CPC分类号: C07D403/14 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要: The invention relates to compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, which are soluble guanylate cyclase activators. The compounds are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.
摘要翻译: 本发明涉及具有式(I)结构的化合物及其药学上可接受的盐,它们是可溶性鸟苷酸环化酶活化剂。 这些化合物能够调节身体产生的环鸟苷酸(cGMP),通常适用于治疗和预防与受干扰的cGMP平衡有关的疾病。 该化合物可用于治疗或预防心血管疾病,内皮功能障碍,舒张功能障碍,动脉粥样硬化,高血压,肺动脉高压,心绞痛,血栓形成,再狭窄,心肌梗死,中风,心功能不全,肺性高血压,勃起功能障碍,支气管哮喘,慢性 肾功能不全,糖尿病或肝硬化。
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