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18 条记录 (耗时 0.039 秒)

    Dna chip based genetic typing
    3.
    发明申请
    Dna chip based genetic typing 有权
    基于Dna芯片的遗传分型

    公开(公告)号：US20070134661A1

    公开(公告)日：2007-06-14

    申请号：US10562803

    申请日：2003-07-18

    申请人： Huafang Gao ,  Xuemei Ma ,  Chi Zhang ,  Qian Chen ,  Dong Wang ,  Yizhe Zhang ,  Yue Tian ,  Rui Zhang ,  Gengxin Lan ,  Yuxiang Zhou ,  Jing Cheng

    发明人： Huafang Gao ,  Xuemei Ma ,  Chi Zhang ,  Qian Chen ,  Dong Wang ,  Yizhe Zhang ,  Yue Tian ,  Rui Zhang ,  Gengxin Lan ,  Yuxiang Zhou ,  Jing Cheng

    IPC分类号： C12Q1/68 ,  C12M3/00

    CPC分类号： C12Q1/6837

    摘要： This invention relates generally to the field of nucleic acid analysis. In particular, the invention provides a method for typing a target gene, using, inter alia, a chip comprising a support suitable for use in nucleic acid hybridization having immobilized thereon an oligonucleotide probe complementary to said target nucleotide sequence and at least one of the following oligonucleotide control probes: a positive control probe, a negative control probe, a hybridization control probe and an immobilization control probe. Oligonucleotide probes or probes arrays for typing a HLA target gene are also provided.

    摘要翻译： 本发明一般涉及核酸分析领域。 特别地，本发明提供了一种用于对目标基因进行分型的方法，特别地，使用包含适合用于核酸杂交的载体的芯片，其上固定有与所述靶核苷酸序列互补的寡核苷酸探针和至少一种以下 寡核苷酸对照探针：阳性对照探针，阴性对照探针，杂交对照探针和固定化对照探针。 还提供了用于分型HLA靶基因的寡核苷酸探针或探针阵列。

    AUTOMATIC POSITIONING AND SENSING MICROELECTRODE ARRAYS
    6.
    发明申请
    AUTOMATIC POSITIONING AND SENSING MICROELECTRODE ARRAYS 有权
    自动定位和感应微电极阵列

    公开(公告)号：US20100270176A1

    公开(公告)日：2010-10-28

    申请号：US12667507

    申请日：2007-07-04

    申请人： Guangxin Xiang ,  Liangbin Pan ,  Wanli Xing ,  Lihua Huang ,  Zhongyao Yu ,  Jing Zhu ,  Yuxiang Zhou ,  Jing Cheng

    发明人： Guangxin Xiang ,  Liangbin Pan ,  Wanli Xing ,  Lihua Huang ,  Zhongyao Yu ,  Jing Zhu ,  Yuxiang Zhou ,  Jing Cheng

    IPC分类号： G01N33/50 ,  G01N27/26

    CPC分类号： G01N33/4836 ,  B01J2219/00653 ,  B01J2219/00743 ,  B01L3/502707 ,  B01L2300/0645 ,  B01L2400/0421 ,  B01L2400/0424

    摘要： A microelectrode sensing device includes a substrate and an array of microelectrode sensors. Each sensor includes a first conductive layer that at least partially conducts electricity. The first conductive layer is formed above the substrate and patterned to include a recording electrode that measures electrical activities of target cells. Each sensor also includes a second conductive layer that at least partially conducts electricity. The second conductive layer is elevated above the first layer and patterned to include multiple positioning electrodes arranged to define a sensing region above the recording electrode. The positioning electrodes are designed to generate an electric field pattern in the sensing region to move and confine the target cells to a sub-region of the sensing region that at least partially overlaps the recording electrode.

    摘要翻译： 微电极感测装置包括基板和微电极传感器阵列。 每个传感器包括至少部分地导电的第一导电层。 第一导电层形成在衬底上并被图案化以包括测量靶细胞的电活动的记录电极。 每个传感器还包括至少部分地传导电的第二导电层。 第二导电层在第一层之上被升高并且被图案化以包括布置成限定记录电极上方的感测区域的多个定位电极。 定位电极被设计成在感测区域中产生电场图案以移动并将目标单元限制在至少部分地与记录电极重叠的感测区域的子区域上。

    Automatic positioning and sensing microelectrode arrays
    7.
    发明授权
    Automatic positioning and sensing microelectrode arrays 有权
    自动定位和感应微电极阵列

    公开(公告)号：US08784633B2

    公开(公告)日：2014-07-22

    申请号：US12667507

    申请日：2007-07-04

    申请人： Guangxin Xiang ,  Liangbin Pan ,  Wanli Xing ,  Lihua Huang ,  Zhongyao Yu ,  Jing Zhu ,  Yuxiang Zhou ,  Jing Cheng

    发明人： Guangxin Xiang ,  Liangbin Pan ,  Wanli Xing ,  Lihua Huang ,  Zhongyao Yu ,  Jing Zhu ,  Yuxiang Zhou ,  Jing Cheng

    IPC分类号： G01N27/447 ,  G01N27/453

    CPC分类号： G01N33/4836 ,  B01J2219/00653 ,  B01J2219/00743 ,  B01L3/502707 ,  B01L2300/0645 ,  B01L2400/0421 ,  B01L2400/0424

    摘要： A microelectrode sensing device includes a substrate and an array of microelectrode sensors. Each sensor includes a first conductive layer that at least partially conducts electricity. The first conductive layer is formed above the substrate and patterned to include a recording electrode that measures electrical activities of target cells. Each sensor also includes a second conductive layer that at least partially conducts electricity. The second conductive layer is elevated above the first layer and patterned to include multiple positioning electrodes arranged to define a sensing region above the recording electrode. The positioning electrodes are designed to generate an electric field pattern in the sensing region to move and confine the target cells to a sub-region of the sensing region that at least partially overlaps the recording electrode.

    摘要翻译： 微电极感测装置包括基板和微电极传感器阵列。 每个传感器包括至少部分地导电的第一导电层。 第一导电层形成在衬底上并被图案化以包括测量靶细胞的电活动的记录电极。 每个传感器还包括至少部分地传导电的第二导电层。 第二导电层在第一层之上被升高并且被图案化以包括布置成限定记录电极上方的感测区域的多个定位电极。 定位电极被设计成在感测区域中产生电场图案以移动并将目标单元限制在至少部分地与记录电极重叠的感测区域的子区域上。

    Nanometer-sized up-converting phosphor fluoride particles and process of preparation
    10.
    发明申请
    Nanometer-sized up-converting phosphor fluoride particles and process of preparation 有权
    纳米级上转换氟化磷颗粒及其制备方法

    公开(公告)号：US20060003466A1

    公开(公告)日：2006-01-05

    申请号：US10511363

    申请日：2003-04-15

    申请人： Guangshun Yi ,  Baoquan Sun ,  Depu Chen ,  Yuxiang Zhou ,  Jing Cheng ,  Wenjun Yang ,  Yue Ge ,  Lianghong Guo

    发明人： Guangshun Yi ,  Baoquan Sun ,  Depu Chen ,  Yuxiang Zhou ,  Jing Cheng ,  Wenjun Yang ,  Yue Ge ,  Lianghong Guo

    IPC分类号： G01N33/553

    CPC分类号： C09K11/7772 ,  C09K11/7773 ,  Y10S977/83 ,  Y10S977/834

    摘要： Nanometer-scaled up-converting fluoride phosphor particles and processes of making them are disclosed. In the process, an aqueous solution consisting of soluble salts of rare-earth metal ions at a molar ratio of (yttrium, lanthanum or gadolinium): ytterbium:(erbium, holmium, terbium or thulium)=(70-90):(0-29):(0.001-15) is mixed a rare-earth metal chelator and a soluble fluoride salt to form precipitates, which are then annealed at an elevated temperature to produce nanometer-scaled up-converting fluoride phosphor particles. The particle size is between 35 nm and 200 nm, and can be controlled by the amount of the metal chelator added to the solution. The nanometer-sized particle is applicable to many biological assays.

    摘要翻译： 公开了纳米级上转换氟化物荧光体颗粒及其制备方法。 在该方法中，以（钇，镧或钆）的摩尔比形成的稀土金属离子的可溶性盐：镱（铒，钬，铽或ium）=（70-90）：（0） -29）:( 0.001-15）混合稀土金属螯合剂和可溶性氟化物盐形成析出物，然后在升高的温度下退火，生成纳米级的上转换氟化物荧光体颗粒。 粒径在35nm和200nm之间，并且可以通过添加到溶液中的金属螯合剂的量来控制。 纳米级粒子适用于许多生物测定。