-
公开(公告)号:US07226938B2
公开(公告)日:2007-06-05
申请号:US10656059
申请日:2003-09-05
申请人: Hui Cai , Nicholas I. Carruthers , Curt A. Dvorak , James P. Edwards , Annette K. Kwok , Jianmei Wei
发明人: Hui Cai , Nicholas I. Carruthers , Curt A. Dvorak , James P. Edwards , Annette K. Kwok , Jianmei Wei
IPC分类号: C07D207/00 , C07D333/02 , A61K31/41 , A01N43/64
CPC分类号: C07D491/04 , C07D495/04
摘要: Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis.
摘要翻译: 公开了某些噻吩并吡喃基和呋喃并吡咯基化合物可用于治疗或预防由组胺H 4受体介导的病症和病症,包括过敏性鼻炎。
-
公开(公告)号:US07645758B2
公开(公告)日:2010-01-12
申请号:US11735306
申请日:2007-04-13
申请人: Hui Cai , Nicholas I. Carruthers , Curt A. Dvorak , James P. Edwards , Annette K. Kwok , Jianmei Wei
发明人: Hui Cai , Nicholas I. Carruthers , Curt A. Dvorak , James P. Edwards , Annette K. Kwok , Jianmei Wei
IPC分类号: C07D241/04 , A61K31/497 , C07D403/00
CPC分类号: C07D491/04 , C07D495/04
摘要: Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis.
摘要翻译: 公开了某些噻吩并吡喃基和呋喃并吡咯基化合物可用于治疗或预防由组胺H 4受体介导的病症和病症,包括过敏性鼻炎。
-
公开(公告)号:US06803362B2
公开(公告)日:2004-10-12
申请号:US10094357
申请日:2002-03-08
申请人: Nicholas I. Carruthers , Wenying Chai , Curt A. Dvorak , James P. Edwards , Cheryl A. Grice , Jill A. Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer D. Kreisberg , Annette K. Kwok , Timothy W. Lovenberg , Kiev S. Ly , Barbara Pio , Chandravadan R. Shah , Siguan Sun , Robin L. Thurmond , Jianmei Wei , Wei Xiao
发明人: Nicholas I. Carruthers , Wenying Chai , Curt A. Dvorak , James P. Edwards , Cheryl A. Grice , Jill A. Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer D. Kreisberg , Annette K. Kwok , Timothy W. Lovenberg , Kiev S. Ly , Barbara Pio , Chandravadan R. Shah , Siguan Sun , Robin L. Thurmond , Jianmei Wei , Wei Xiao
IPC分类号: A61K3133
CPC分类号: C07D401/12 , A61K31/496 , C07D209/42
摘要: Heterocyclic compounds and methods of making them and using them.
摘要翻译: 杂环化合物及其制备方法和使用方法。
-
公开(公告)号:US07504426B2
公开(公告)日:2009-03-17
申请号:US10655381
申请日:2003-09-04
申请人: Nicholas I. Carruthers , Curt A. Dvorak , James P. Edwards , Cheryl A. Grice , Jill A. Jablonowski , Kiev S. Ly , Barbara A. Pio , Chandravadan R. Shah , Jennifer D. Venable
发明人: Nicholas I. Carruthers , Curt A. Dvorak , James P. Edwards , Cheryl A. Grice , Jill A. Jablonowski , Kiev S. Ly , Barbara A. Pio , Chandravadan R. Shah , Jennifer D. Venable
IPC分类号: C07D235/00 , A01N43/05 , A61K31/415
CPC分类号: C07D235/24 , C07D263/58 , C07D277/68 , C07D403/06 , C07D451/04 , C07D471/04
摘要: Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis.
摘要翻译: 公开了某些噻吩并吡喃基和呋喃并吡咯基化合物可用于治疗或预防由组胺H 4受体介导的病症和病症,包括过敏性鼻炎。
-
公开(公告)号:US20110218338A1
公开(公告)日:2011-09-08
申请号:US13084226
申请日:2011-04-11
申请人: Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
发明人: Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
IPC分类号: C07D403/14 , C07D403/04 , C07D413/14 , C07D405/14
CPC分类号: C07D498/04 , C07D239/48 , C07D239/70 , C07D239/95 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10 , C07D519/00
摘要: 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritus.
摘要翻译: 描述了2-氨基嘧啶化合物,其可用作H 4受体调节剂。 这些化合物可用于治疗由H 4受体活性介导的疾病状态,病症和病症的药物组合物和方法,例如过敏,哮喘,自身免疫性疾病和瘙痒症。
-
公开(公告)号:US07589202B2
公开(公告)日:2009-09-15
申请号:US11517062
申请日:2006-09-07
申请人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号: C07D403/06
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
摘要翻译: 取代的吡唑,其制备方法,含有它们的组合物,以及使用它们来治疗例如由组织蛋白酶S介导的自身免疫性疾病的方法。
-
公开(公告)号:US20080300255A1
公开(公告)日:2008-12-04
申请号:US12220516
申请日:2008-07-24
申请人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号: A61K31/497 , A61P37/00
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
-
公开(公告)号:US20080293732A1
公开(公告)日:2008-11-27
申请号:US12220539
申请日:2008-07-24
申请人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号: A61K31/496 , A61P37/00
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
-
公开(公告)号:US07393850B2
公开(公告)日:2008-07-01
申请号:US11517212
申请日:2006-09-07
申请人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号: A61K31/4965 , C07D401/02 , C07D403/04
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
-
公开(公告)号:US07429591B2
公开(公告)日:2008-09-30
申请号:US11517518
申请日:2006-09-07
申请人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号: A61K31/497 , C07D403/12
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
-
-
-
-
-
-
-
-
-