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公开(公告)号:US20180111923A1
公开(公告)日:2018-04-26
申请号:US15793770
申请日:2017-10-25
申请人: Hui Li , Thilo Heckrodt , Yan Chen , Ryan Kelley , Darren McMurtrie , Kin Tso , Vanessa Taylor , Rajinder Singh , Rose Yen , Jack Maung
发明人: Hui Li , Thilo Heckrodt , Yan Chen , Ryan Kelley , Darren McMurtrie , Kin Tso , Vanessa Taylor , Rajinder Singh , Rose Yen , Jack Maung
IPC分类号: C07D413/14
CPC分类号: C07D413/14 , A61P29/00
摘要: Disclosed embodiments concern interleukin receptor associated kinases (IRAK) inhibitors, such as oxazole compounds, and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.
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公开(公告)号:US20180111917A1
公开(公告)日:2018-04-26
申请号:US15793743
申请日:2017-10-25
申请人: Kin Tso , Hui Li , Yan Chen , Rose Yen , Vanessa Taylor , Thilo Heckrodt , Rajinder Singh , Simon Shaw
发明人: Kin Tso , Hui Li , Yan Chen , Rose Yen , Vanessa Taylor , Thilo Heckrodt , Rajinder Singh , Simon Shaw
IPC分类号: C07D401/14 , C07D401/12 , C07D413/14 , C07D403/14 , C07D403/12
CPC分类号: C07D401/14 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/04
摘要: Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.
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公开(公告)号:US20100190770A1
公开(公告)日:2010-07-29
申请号:US12692493
申请日:2010-01-22
申请人: Hui Li , Thilo J. Heckrodt , Yan Chen , Darren John McMurtrie , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Sambaiah Thota , Rose Yen
发明人: Hui Li , Thilo J. Heckrodt , Yan Chen , Darren John McMurtrie , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Sambaiah Thota , Rose Yen
IPC分类号: A61K31/397 , C07D403/12 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D487/08 , A61K31/551 , A61P27/06 , A61P27/00 , A61P1/16 , A61P13/12 , A61P9/00
CPC分类号: C07D413/12 , A61K31/155 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/635 , A61K31/675 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/04 , C07D413/14 , C07D419/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/08 , C07D498/04 , C07F9/65583
摘要: Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.
摘要翻译: 公开了式I化合物,含有它们的组合物,以及用于化合物和组合物用于治疗JAK途径的调节或JAK激酶,特别是JAK 2和JAK 3的抑制在治疗上有用的条件的方法。
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公开(公告)号:US20120028923A1
公开(公告)日:2012-02-02
申请号:US13192344
申请日:2011-07-27
申请人: Hui Li , Thilo J. Heckrodt , Yan Chen , Darren John McMurtrie , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
发明人: Hui Li , Thilo J. Heckrodt , Yan Chen , Darren John McMurtrie , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
IPC分类号: A61K31/506 , C12N9/99 , A61P37/06 , A61K31/675 , C07D413/14 , A61K31/685 , C07D413/12 , C07F9/6558
CPC分类号: C07D413/12 , C07B59/002 , C07B2200/05 , C07F9/65583
摘要: Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful. Also disclosed are methods of making the compounds.
摘要翻译: 公开了式I的化合物,含有它们的组合物,以及用于化合物和组合物用于治疗JAK途径的调节或JAK激酶,特别是JAK 2和JAK 3的抑制在治疗上有用的条件的方法。 还公开了制备该化合物的方法。
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公开(公告)号:US20120016131A1
公开(公告)日:2012-01-19
申请号:US13241041
申请日:2011-09-22
申请人: Hui Li , Thilo J. Heckrodt , Yan Chen , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
发明人: Hui Li , Thilo J. Heckrodt , Yan Chen , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
IPC分类号: C07D413/12
CPC分类号: C07D413/12 , A61K31/155 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/635 , A61K31/675 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/04 , C07D413/14 , C07D419/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/08 , C07D498/04 , C07F9/65583
摘要: Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.
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公开(公告)号:US20120010407A1
公开(公告)日:2012-01-12
申请号:US13241037
申请日:2011-09-22
申请人: Hui Li , Thilo J. Heckrodt , Yan Chen , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
发明人: Hui Li , Thilo J. Heckrodt , Yan Chen , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
IPC分类号: C07F9/08
CPC分类号: C07D413/12 , A61K31/155 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/635 , A61K31/675 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/04 , C07D413/14 , C07D419/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/08 , C07D498/04 , C07F9/65583
摘要: Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.
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公开(公告)号:US08343954B2
公开(公告)日:2013-01-01
申请号:US13192344
申请日:2011-07-27
申请人: Hui Li , Thilo J. Heckrodt , Yan Chen , Darren John McMurtrie , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
发明人: Hui Li , Thilo J. Heckrodt , Yan Chen , Darren John McMurtrie , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
IPC分类号: A61K31/132 , A61K31/505 , A61K31/55 , A61K31/535 , C07D243/12 , C07D405/12 , C07D413/12
CPC分类号: C07D413/12 , C07B59/002 , C07B2200/05 , C07F9/65583
摘要: Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful. Also disclosed are methods of making the compounds.
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公开(公告)号:US20120016122A1
公开(公告)日:2012-01-19
申请号:US13241024
申请日:2011-09-22
申请人: Hui Li , Thilo J. Heckrodt , Yan Chen , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
发明人: Hui Li , Thilo J. Heckrodt , Yan Chen , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
IPC分类号: C07D413/12
CPC分类号: C07D413/12 , A61K31/155 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/635 , A61K31/675 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/04 , C07D413/14 , C07D419/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/08 , C07D498/04 , C07F9/65583
摘要: Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.
摘要翻译: 公开了式I的化合物,含有它们的组合物,以及用于化合物和组合物用于治疗JAK途径的调节或JAK激酶,特别是JAK 2和JAK 3的抑制在治疗上有用的条件的方法。
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公开(公告)号:US08324200B2
公开(公告)日:2012-12-04
申请号:US12692493
申请日:2010-01-22
申请人: Hui Li , Thilo J. Heckrodt , Yan Chen , Darren John McMurtrie , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Sambaiah Thota , Rose Yen
发明人: Hui Li , Thilo J. Heckrodt , Yan Chen , Darren John McMurtrie , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Sambaiah Thota , Rose Yen
IPC分类号: A61K31/33 , A61K31/55 , A61K31/505 , A61K31/535 , C07D243/06 , C07D413/14 , C07D401/14
CPC分类号: C07D413/12 , A61K31/155 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/635 , A61K31/675 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/04 , C07D413/14 , C07D419/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/08 , C07D498/04 , C07F9/65583
摘要: Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.
摘要翻译: 公开了式I的化合物,含有它们的组合物,以及用于化合物和组合物用于治疗JAK途径的调节或JAK激酶,特别是JAK 2和JAK 3的抑制在治疗上有用的条件的方法。
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公开(公告)号:US20120010406A1
公开(公告)日:2012-01-12
申请号:US13241036
申请日:2011-09-22
申请人: Hui Li , Thilo J. Heckrodt , Yan Chen , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
发明人: Hui Li , Thilo J. Heckrodt , Yan Chen , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
IPC分类号: C07F9/6574
CPC分类号: C07D413/12 , A61K31/155 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/635 , A61K31/675 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/04 , C07D413/14 , C07D419/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/08 , C07D498/04 , C07F9/65583
摘要: Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.
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