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公开(公告)号:US20110301171A1
公开(公告)日:2011-12-08
申请号:US13151326
申请日:2011-06-02
申请人: Humberto Bartolome Arzeno , Lubov K. Filonova , David Michael Goldstein , Leyi Gong , Bradley E. Loe , Erin M. O'Brien , Wylie Solang Palmer , David Mark Rotstein , Tania M. Silva , Yun-Chou Tan
发明人: Humberto Bartolome Arzeno , Lubov K. Filonova , David Michael Goldstein , Leyi Gong , Bradley E. Loe , Erin M. O'Brien , Wylie Solang Palmer , David Mark Rotstein , Tania M. Silva , Yun-Chou Tan
IPC分类号: A61K31/506 , C07D409/14 , A61P3/10 , C07D487/08 , A61P29/00 , A61P11/06 , C07D401/14 , C07D403/14
CPC分类号: C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D409/14 , C07D487/02
摘要: Compounds of formula I or pharmaceutically acceptable salts thereof, wherein R5 is a group of formula (a) or (b): and wherein m, n, p, q, X, Y, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity.
摘要翻译: 式I化合物或其药学上可接受的盐,其中R 5是式(a)或(b)的基团:其中m,n,p,q,X,Y,R 1,R 2,R 3,R 4,R 5,R 6 ,R7,R8和R9如本文所定义。 本文公开的化合物和组合物可用于调节JNK的活性并治疗与JNK活性相关的疾病。
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公开(公告)号:US08642601B2
公开(公告)日:2014-02-04
申请号:US13151326
申请日:2011-06-02
申请人: Humberto Bartolome Arzeno , Lubov K. Filonova , David Michael Goldstein , Leyi Gong , Bradley E. Loe , Erin M. O'Brien , Wylie Solang Palmer , David Mark Rotstein , Tania M. Silva , Yun-Chou Tan
发明人: Humberto Bartolome Arzeno , Lubov K. Filonova , David Michael Goldstein , Leyi Gong , Bradley E. Loe , Erin M. O'Brien , Wylie Solang Palmer , David Mark Rotstein , Tania M. Silva , Yun-Chou Tan
IPC分类号: A01N43/54 , C07D239/12 , C07D401/04 , C07D471/04 , C07D471/22 , C07D487/04 , A01N43/56 , A61K31/415
CPC分类号: C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D409/14 , C07D487/02
摘要: Compounds of formula I or pharmaceutically acceptable salts thereof, wherein R5 is a group of formula (a) or (b): and wherein m, n, p, q, X, Y, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity.
摘要翻译: 式I化合物或其药学上可接受的盐,其中R 5是式(a)或(b)的基团:其中m,n,p,q,X,Y,R 1,R 2,R 3,R 4,R 5,R 6 ,R7,R8和R9如本文所定义。 本文公开的化合物和组合物可用于调节JNK的活性并治疗与JNK活性相关的疾病。
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