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公开(公告)号:US20120115793A1
公开(公告)日:2012-05-10
申请号:US13120386
申请日:2009-09-22
CPC分类号: C07K14/47
摘要: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
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公开(公告)号:US20120178700A1
公开(公告)日:2012-07-12
申请号:US13120360
申请日:2009-09-22
CPC分类号: C07K14/47
摘要: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
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公开(公告)号:US20120115783A1
公开(公告)日:2012-05-10
申请号:US13120376
申请日:2009-09-22
CPC分类号: C07K14/4702 , C07K7/56
摘要: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
摘要翻译: 本发明提供新颖的拟肽大环化合物和使用这种大环化合物治疗疾病的方法。
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公开(公告)号:US20120101047A1
公开(公告)日:2012-04-26
申请号:US13120370
申请日:2009-09-22
CPC分类号: C07K14/4702 , A61K38/00 , Y02A50/414
摘要: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
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公开(公告)号:US20130072439A1
公开(公告)日:2013-03-21
申请号:US13497522
申请日:2010-09-22
申请人: Huw M. Nash , Rosana Kapeller-Libermann , Jia-wen Han , Tomi K. Sawyer , Justin Noehre , Noriyuki Kawahata
发明人: Huw M. Nash , Rosana Kapeller-Libermann , Jia-wen Han , Tomi K. Sawyer , Justin Noehre , Noriyuki Kawahata
摘要: Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an a,a-disubstituted amino acid, or may comprise a crosslinker linking the a-positions of at least two amino acids or at least one of said two amino acids may be an a,a-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.
摘要翻译: 公开了包含螺旋的拟肽大环化合物,例如α螺旋,以及使用这种大环化合物治疗诸如癌症的疾病的方法。 在其它方面,拟肽大环化合物包含a,α-二取代的氨基酸,或可以包含连接至少两个氨基酸的a-位的交联剂或所述两个氨基酸中的至少一个可以是a, 氨基酸。 进一步包括靶向Wnt信号通路的组分,例如Tcf4- / 3-连环蛋白复合物。
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公开(公告)号:US08808694B2
公开(公告)日:2014-08-19
申请号:US13352223
申请日:2012-01-17
申请人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Jiawen Han
发明人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Jiawen Han
IPC分类号: A61K39/395 , C12N15/00 , A61K38/12 , A61K38/17
CPC分类号: C07K7/64 , A61K38/12 , A61K38/1761 , A61K45/06
摘要: The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
摘要翻译: 本发明提供用于治疗细胞增殖性疾病如癌症和免疫增殖性疾病的生物活性的拟肽大环化合物。
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公开(公告)号:US20120149648A1
公开(公告)日:2012-06-14
申请号:US13352223
申请日:2012-01-17
申请人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Jiawen Han
发明人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Jiawen Han
CPC分类号: C07K7/64 , A61K38/12 , A61K38/1761 , A61K45/06
摘要: The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
摘要翻译: 本发明提供用于治疗细胞增殖性疾病如癌症和免疫增殖性疾病的生物活性的拟肽大环化合物。
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公开(公告)号:US20090275519A1
公开(公告)日:2009-11-05
申请号:US12378047
申请日:2009-02-09
申请人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Jiawen Han
发明人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Jiawen Han
CPC分类号: C07K7/64 , A61K38/12 , A61K38/1761 , A61K45/06
摘要: The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
摘要翻译: 本发明提供用于治疗细胞增殖性疾病如癌症和免疫增殖性疾病的生物活性的拟肽大环化合物。
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公开(公告)号:US09458202B2
公开(公告)日:2016-10-04
申请号:US12625533
申请日:2009-11-24
申请人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata
发明人: Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata
CPC分类号: G01N33/68 , A61K31/02 , C07K2/00 , C07K14/001 , C07K14/4705 , C07K14/4747 , C07K14/4748
摘要: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
摘要翻译: 本发明提供了相对于其相应多肽具有改进性质的生物活性的拟肽大环化合物。 本发明另外提供了制备和使用这种大环化合物的方法,例如在治疗应用中。
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公开(公告)号:US20090326192A1
公开(公告)日:2009-12-31
申请号:US12420816
申请日:2009-04-08
申请人: Huw M. Nash , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Vincent Guerlavais , Matthew Iadanza
发明人: Huw M. Nash , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Vincent Guerlavais , Matthew Iadanza
IPC分类号: C07K2/00
CPC分类号: C07K7/56 , C07K1/1077 , C07K1/113 , C07K1/1136 , G01N33/68 , G01N2500/04
摘要: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
摘要翻译: 本发明提供了相对于其相应多肽具有改进性质的生物活性的拟肽大环化合物。 本发明另外提供了制备和使用这种大环化合物的方法,例如在治疗应用中。
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