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    Tricyclic anilide spirohydantion CGRP receptor antagonists
    7.
    发明授权
    Tricyclic anilide spirohydantion CGRP receptor antagonists 有权
    三环酰苯胺螺旋CGRP受体拮抗剂

    公开(公告)号：US07750010B2

    公开(公告)日：2010-07-06

    申请号：US11662702

    申请日：2005-09-09

    申请人： Ian M. Bell ,  Steven N. Gallicchio ,  C. Blair Zartman ,  Cory R. Theberge ,  Xufang Zhang

    发明人： Ian M. Bell ,  Steven N. Gallicchio ,  C. Blair Zartman ,  Cory R. Theberge ,  Xufang Zhang

    IPC分类号： C07D401/12 ,  C07D403/12 ,  A61K31/519 ,  A61K31/4166 ,  A61P25/06

    CPC分类号： C07D487/06 ,  C07D471/06

    摘要： The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, T, U, V, W, X, Y, Z, R4, R5a?, R5b, R5c, R6, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译： 本发明涉及式I化合物：其中A1，A2，B1，B2，B3，B4，D1，D2，T，U，V，W，X，Y，Z，R4，R5a，R5b ，R 5，R 6，m和n如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

    Spirohydantoin tricyclic CGRP receptor antagonists
    9.
    发明授权
    Spirohydantoin tricyclic CGRP receptor antagonists 有权
    螺乙素三环CGRP受体拮抗剂

    公开(公告)号：US07968540B2

    公开(公告)日：2011-06-28

    申请号：US12085008

    申请日：2006-11-14

    申请人： Ian M. Bell ,  Craig A. Stump ,  Cory R. Theberge ,  Steven N. Gallicchio ,  C. Blair Zartman

    发明人： Ian M. Bell ,  Craig A. Stump ,  Cory R. Theberge ,  Steven N. Gallicchio ,  C. Blair Zartman

    IPC分类号： A61K31/55 ,  C07D243/04 ,  C07D487/10

    CPC分类号： C07D519/00

    摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B1, B2, B3, B4, D1, D2, E1, E2, E3, E4, E5, G1, G2, R6, T, U, V, W, X, Y and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译： 式I化合物（其中变量A1，A2，A3，A4，A5，A6，A7，B1，B2，B3，B4，D1，D2，E1，E2，E3，E4，E5，G1，G2， T，U，V，W，X，Y和Z如本文所述），其是CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

    Spirohydantoin Tricyclic CGRP Receptor Antagonists
    10.
    发明申请
    Spirohydantoin Tricyclic CGRP Receptor Antagonists 有权
    螺乙双胍三环CGRP受体拮抗剂

    公开(公告)号：US20090281080A1

    公开(公告)日：2009-11-12

    申请号：US12085008

    申请日：2006-11-14

    申请人： Ian M. Bell ,  Craig A. Stump ,  Cory R. Theberge ,  Steven N. Gallicchio ,  C. Blair Zartman

    发明人： Ian M. Bell ,  Craig A. Stump ,  Cory R. Theberge ,  Steven N. Gallicchio ,  C. Blair Zartman

    IPC分类号： A61K31/55 ,  A61K31/4985 ,  A61K31/438 ,  C07D487/06 ,  C07D471/06

    CPC分类号： C07D519/00

    摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B1, B2, B3, B4, D1, D2, E1, E2, E3, E4, E5, G1, G2, R6, T, U, V, W, X, Y and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译： 式I化合物（其中变量A1，A2，A3，A4，A5，A6，A7，B1，B2，B3，B4，D1，D2，E1，E2，E3，E4，E5，G1，G2， T，U，V，W，X，Y和Z如本文所述），其是CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。