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公开(公告)号：US20120122900A1
公开(公告)日：2012-05-17
申请号：US13293177
申请日：2011-11-10
申请人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： A61K31/437 , A61K31/527 , A61P25/06 , C07D471/20
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：US08754096B2
公开(公告)日：2014-06-17
申请号：US13293166
申请日：2011-11-10
申请人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Heather E. Stevenson , Cheng Wang , C. Blair Zartman
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Heather E. Stevenson , Cheng Wang , C. Blair Zartman
IPC分类号： A61K31/4545 , A61K31/527 , A61P25/06 , C07D471/20
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺氮杂茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US08912210B2
公开(公告)日：2014-12-16
申请号：US13293177
申请日：2011-11-10
申请人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： A01N43/42 , A61K31/44 , C07D221/02
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：US20120122899A1
公开(公告)日：2012-05-17
申请号：US13293166
申请日：2011-11-10
申请人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Heather E. Stevenson , Cheng Wang , C. Blair Zartman
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Heather E. Stevenson , Cheng Wang , C. Blair Zartman
IPC分类号： A61K31/439 , A61K31/527 , A61P25/06 , C07D471/20
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺氮杂茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US08883807B2
公开(公告)日：2014-11-11
申请号：US13884632
申请日：2011-11-10
申请人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , Blair C. Zartman , Heather E. Stevenson
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , Blair C. Zartman , Heather E. Stevenson
IPC分类号： A01N43/90 , A61K31/519 , A01N43/42 , A61K31/44 , C07D487/00 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02 , A61K31/506 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , A61K31/506 , C07D487/04
摘要： The present invention is directed to piperidinone carboxamide indane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺二氢化茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20130231358A1
公开(公告)日：2013-09-05
申请号：US13884632
申请日：2011-11-10
申请人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , Blair C. Zartman , Heather E. Stevenson
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , Blair C. Zartman , Heather E. Stevenson
IPC分类号： C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , A61K31/506 , C07D487/04
摘要： The present invention is directed to piperidinone carboxamide indane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺二氢化茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US08765759B2
公开(公告)日：2014-07-01
申请号：US12934208
申请日：2009-03-24
申请人： Harold G. Selnick , Ian M. Bell , Melody McWherter , Donnette D. Staas , Shawn J. Stachel , Thomas Steele , Craig Stump , Michael R. Wood , C. Blair Zartman
发明人： Harold G. Selnick , Ian M. Bell , Melody McWherter , Donnette D. Staas , Shawn J. Stachel , Thomas Steele , Craig Stump , Michael R. Wood , C. Blair Zartman
IPC分类号： A61K31/437 , A61K31/497 , A61K31/4985
CPC分类号： C07D471/10 , C07D403/06 , C07D471/20 , C07D519/00
摘要： The present invention is directed to compounds of the formula: (wherein variables A1, A2, A3, G1, G2, G3, G4, J, Ea, Eb, Ec, R6, R7, and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及下式的化合物：其中作为拮抗剂的式（其中变量A1，A2，A3，G1，G2，G3，G4，J，Ea，Eb，Ec，R6，R7和Y如本文所述） 的CGRP受体，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20110021516A1
公开(公告)日：2011-01-27
申请号：US12934208
申请日：2009-03-24
申请人： Harold G. Selnick , Ian M. Bell , Melody McWherter , Donnette D. Staas , Shawn J. Stachel , Thomas Steele , Craig Stump , Michael R. Wood , C. Blair Zartman
发明人： Harold G. Selnick , Ian M. Bell , Melody McWherter , Donnette D. Staas , Shawn J. Stachel , Thomas Steele , Craig Stump , Michael R. Wood , C. Blair Zartman
IPC分类号： A61K31/5365 , C07D471/04 , A61K31/496 , A61P25/06
CPC分类号： C07D471/10 , C07D403/06 , C07D471/20 , C07D519/00
摘要： The present invention is directed to compounds of the formula (I): (wherein variables A1, A2, A3, A4, A5, A6, A7, A8, G1, G2, G3, G4, J, Q, Ea, Eb, Ec, R6, R7, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式（I）的化合物：（其中变量A1，A2，A3，A4，A5，A6，A7，A8，G1，G2，G3，G4，J，Q，Ea，Eb，Ec ，R6，R7，RPG和Y如本文所述），其是CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20110224201A1
公开(公告)日：2011-09-15
申请号：US13121784
申请日：2009-09-29
IPC分类号： A61K31/537 , C07D498/20 , C07D498/04 , A61P25/06 , A61P25/00
CPC分类号： C07D498/20 , C07D498/04 , C07D498/10
摘要： Compounds of Formula (I), (wherein variables A1, A2, A3, A4, A5, A6, A7, A8, L, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG, W, Y and Z are as described herein) useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.
摘要翻译： 式（I）化合物（其中变量A1，A2，A3，A4，A5，A6，A7，A8，L，J，Q，R4，Ea，Eb，Ec，R6，R7，Re，Rf， W，Y和Z如本文所述）可用作CGRP受体的拮抗剂，并且可用于治疗或预防涉及CGRP受体的疾病，例如头痛，特别是偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP受体的疾病中的用途。
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公开(公告)号：US08685965B2
公开(公告)日：2014-04-01
申请号：US13121784
申请日：2009-09-29
IPC分类号： A61K31/537
CPC分类号： C07D498/20 , C07D498/04 , C07D498/10
摘要： Compounds of Formula (I), (wherein variables A1, A2, A3, A4, A5, A6, A7, A8, L, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG, W, Y and Z are as described herein) useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.
摘要翻译： 式（I）化合物（其中变量A1，A2，A3，A4，A5，A6，A7，A8，L，J，Q，R4，Ea，Eb，Ec，R6，R7，Re，Rf， W，Y和Z如本文所述）可用作CGRP受体的拮抗剂，并且可用于治疗或预防涉及CGRP受体的疾病，例如头痛，特别是偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP受体的疾病中的用途。
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