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公开(公告)号：US20050130954A1
公开(公告)日：2005-06-16
申请号：US10993173
申请日：2004-11-19
申请人： Ian Mitchell , Keith Spencer , Peter Stengel , Yongxin Han , Nicholas Kallan , Mark Munson , Guy Vigers , James Blake , Anthony Piscopio , John Josey , Scott Miller , Dengming Xiao , Riu Xu , Chang Rao , Bin Wang , April Bernacki
发明人： Ian Mitchell , Keith Spencer , Peter Stengel , Yongxin Han , Nicholas Kallan , Mark Munson , Guy Vigers , James Blake , Anthony Piscopio , John Josey , Scott Miller , Dengming Xiao , Riu Xu , Chang Rao , Bin Wang , April Bernacki
IPC分类号： A61K20060101 , A61K31/496 , A61K31/519 , A61K31/53
CPC分类号： C07D239/94 , B41M3/008 , B44F1/10 , C07D231/56 , C07D237/28 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , G09F13/16 , Y10T428/24802 , Y10T428/24851 , Y10T428/25 , Y10T428/31507 , Y10T428/31551 , Y10T428/31786 , Y10T428/31855
摘要： The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明提供包括拆分的对映异构体，非对映异构体，溶剂合物和药学上可接受的盐的化合物，其包含式：<？在线公式描述=“在线公式”end =“lead”→> AL-CR < in-line-formula description =“In-line Formulas”end =“tail”？>其中CR是循环核心组，L是连接组，A如本文所定义。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US20070142413A1
公开(公告)日：2007-06-21
申请号：US10595807
申请日：2004-11-15
申请人： Michael Block , John Lee , David Scott , Haixia Wang , Tao Wang , Dingwei Yu , Yongxin Han , John Josey , Bin Wang
发明人： Michael Block , John Lee , David Scott , Haixia Wang , Tao Wang , Dingwei Yu , Yongxin Han , John Josey , Bin Wang
IPC分类号： A61K31/506 , C07D403/14 , C07D413/14
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Compounds of formula (I): and their use in the inhibition of Trk activity are described.
摘要翻译： 描述式（I）化合物及其在抑制Trk活性中的用途。
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公开(公告)号：US07622482B2
公开(公告)日：2009-11-24
申请号：US11816376
申请日：2006-02-15
申请人： Yongxin Han , Michelle Lamb , Peter Mohr , Bin Wang , Tao Wang , Dingwei Yu
发明人： Yongxin Han , Michelle Lamb , Peter Mohr , Bin Wang , Tao Wang , Dingwei Yu
IPC分类号： A01N43/42 , A61K31/44 , C07D471/00 , C07D487/00 , C07D471/02 , C07D491/02 , C07D498/02
CPC分类号： C07D471/04 , C07D401/12 , C07D403/12 , C07D473/32
摘要： This invention relates to novel compounds having the formula (I): and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
摘要翻译： 本发明涉及具有式（I）的新化合物及其药物组合物及其使用方法。 这些新型化合物为癌症提供治疗。
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公开(公告)号：US20090137624A1
公开(公告)日：2009-05-28
申请号：US11816376
申请日：2006-02-15
申请人： Michelle Lamb , Tao Wang , Dingwel Yu , Yongxin Han , Peter Mohr , Bin Wang
发明人： Michelle Lamb , Tao Wang , Dingwel Yu , Yongxin Han , Peter Mohr , Bin Wang
IPC分类号： A61K31/52 , C07D471/02 , A61K31/4745 , C07D473/02
CPC分类号： C07D471/04 , C07D401/12 , C07D403/12 , C07D473/32
摘要： This invention relates to novel compounds having the formula (I): and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
摘要翻译： 本发明涉及具有式（I）的新化合物及其药物组合物及其使用方法。 这些新型化合物为癌症提供治疗。
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公开(公告)号：US20100152219A1
公开(公告)日：2010-06-17
申请号：US12712659
申请日：2010-02-25
申请人： Michael Howard Block , John W. Lee , David Scott , Haixia Wang , Tao Wang , Dingwei Yu , Yongxin Han , John Anthony Josey , Bin Wang
发明人： Michael Howard Block , John W. Lee , David Scott , Haixia Wang , Tao Wang , Dingwei Yu , Yongxin Han , John Anthony Josey , Bin Wang
IPC分类号： A61K31/506 , C07D403/12
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Compounds of formula (I): and their use in the inhibition of Trk activity are described.
摘要翻译： 描述式（I）化合物及其在抑制Trk活性中的用途。
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公开(公告)号：US20230029788A1
公开(公告)日：2023-02-02
申请号：US17962691
申请日：2022-10-10
申请人： Jiayi CHEN , Bin Wang
发明人： Jiayi CHEN , Bin Wang
IPC分类号： H04L9/32
摘要： A method of deploying a certificate, an electronic device, and a storage medium are provided, which relate to a field of an artificial intelligence technology, in particular to cloud computing, network security and other technical fields. A specific implementation solution includes: determining site domain name information for at least one certificate to be deployed, in response to a certificate deployment request from a client, wherein the certificate deployment request is for at least one certificate of network security protocol; determining, from at least one certificate identification information related to the client, target certificate identification information matched with the site domain name information; and acquiring certificate attribute information corresponding to the target certificate identification information, so that the at least one certificate is deployed to at least one website based on the certificate attribute information.
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公开(公告)号：US10346002B2
公开(公告)日：2019-07-09
申请号：US14915371
申请日：2013-09-30
发明人： Yang Luo , Zhi-Yuan Jing , Bin Wang , YanYan Ou
IPC分类号： G06F3/0484 , G06F11/36 , G06F8/30 , H04L29/08 , G06F9/451
摘要： A proxy tool can be controlled by injecting widget code into application code of a response to an application request. That response is returned client device such that when the application and widget code are processed, the widget code inserts a widget viewable with the rendered application code. Upon a determination that a subsequent request from the client device corresponds to user interaction with the widget and not the rendered application code, a state of the proxy tool is updated based on the sub sequent request.
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公开(公告)号：US10206997B2
公开(公告)日：2019-02-19
申请号：US14356414
申请日：2011-11-10
申请人： Bin Wang , Shuang Geng
发明人： Bin Wang , Shuang Geng
IPC分类号： A61K31/195 , A61K31/20 , A61K31/30 , A61K31/7004 , A61K36/05 , A61K39/29 , A61K9/00 , A61K39/39 , C12N7/00 , A61K39/12 , A61K39/00
摘要： Provided herein is a vaccine that combines a vaccine facilitator and a DNA construct encoding an antigen to elicit antigen-specific antibody responses, wherein the vaccine facilitator is a Na/K pump inhibitor. Cellular entry of the DNA is accelerated as compared to other vaccines that do not contain the vaccine facilitator.
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