-
公开(公告)号:US20050186198A1
公开(公告)日:2005-08-25
申请号:US11088511
申请日:2005-03-24
申请人: Ignacio Aliagas-Martin , Dean Artis , Michael Dina , John Flygare , Richard Goldsmith , Regina Munroe , Alan Olivero , Richard Pastor , Thomas Rawson , Kirk Robarge , Daniel Sutherlin , Kenneth Weese , Aihe Zhou , Yan Zhu
发明人: Ignacio Aliagas-Martin , Dean Artis , Michael Dina , John Flygare , Richard Goldsmith , Regina Munroe , Alan Olivero , Richard Pastor , Thomas Rawson , Kirk Robarge , Daniel Sutherlin , Kenneth Weese , Aihe Zhou , Yan Zhu
IPC分类号: C07D333/34 , A61K31/18 , A61K31/196 , A61K31/216 , A61K31/381 , A61P7/02 , A61P9/10 , C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51 , A61K38/48 , A61K31/445 , A61K31/54 , A61K31/60
CPC分类号: C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
摘要: Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
-
公开(公告)号:US20070037813A1
公开(公告)日:2007-02-15
申请号:US11537482
申请日:2006-09-29
申请人: Ignacio Aliagas-Martin , Dean Artis , Michael Dina , John Flygare , Richard Goldsmith , Regina Munroe , Alan Olivero , Richard Pastor , Thomas Rawson , Kirk Robarge , Daniel Sutherlin , Kenneth Weese , Aihe Zhou , Yan Zhu
发明人: Ignacio Aliagas-Martin , Dean Artis , Michael Dina , John Flygare , Richard Goldsmith , Regina Munroe , Alan Olivero , Richard Pastor , Thomas Rawson , Kirk Robarge , Daniel Sutherlin , Kenneth Weese , Aihe Zhou , Yan Zhu
IPC分类号: A61K31/50 , A61K31/44 , A61K31/165 , C07D237/02
CPC分类号: C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
摘要: Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
摘要翻译: 具有如下结构的化合物可用于抑制丝氨酸蛋白酶,例如TF /因子VIIa,因子Xa,凝血酶和激肽释放酶。 这些化合物可用于预防和/或治疗凝血障碍的方法。
-
公开(公告)号:US20050187284A1
公开(公告)日:2005-08-25
申请号:US11111105
申请日:2005-04-20
申请人: Dean Artis , David Jackson , Thomas Rawson , Mark Reynolds , Daniel Sutherlin , Mark Stanley
发明人: Dean Artis , David Jackson , Thomas Rawson , Mark Reynolds , Daniel Sutherlin , Mark Stanley
IPC分类号: A61K31/195 , A61K31/403 , A61P1/04 , A61P1/12 , A61P1/16 , A61P1/18 , A61P3/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P15/14 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P37/00 , A61P43/00 , C07C233/25 , C07C233/60 , C07C233/81 , C07C237/04 , C07C237/20 , C07C237/22 , C07C237/42 , C07D207/16 , C07D207/48 , C07D209/88 , C07D403/12 , C07D405/12 , A61K31/401 , C07C237/24
CPC分类号: C07D403/12 , C07C233/25 , C07C233/60 , C07C233/81 , C07C237/04 , C07C237/20 , C07C237/22 , C07C2601/08 , C07C2603/18 , C07C2603/32 , C07D207/16 , C07D207/48 , C07D209/88 , C07D405/12
摘要: Provided are compounds of formula (I) wherein A, Q, W, X, Y, Z, R1 to R4, m and n are as defined herein. Compounds of the invention bind to α4 integrin receptors and thereby inhibit binding of ligands for α4 integrins which is useful for prophylactic and/or therapeutic treatment of diseases and conditions associated with α4 integrins or their ligands.
-
公开(公告)号:US20080188514A1
公开(公告)日:2008-08-07
申请号:US11961901
申请日:2007-12-20
申请人: Guoxian Wu , Wayne Spevak , Songyuan Shi , Hanna Cho , Prabha N. Ibrahim , Chao Zhang , Shenghua Shi , Yong Zhou , Dean Artis , Jiazhong Zhang
发明人: Guoxian Wu , Wayne Spevak , Songyuan Shi , Hanna Cho , Prabha N. Ibrahim , Chao Zhang , Shenghua Shi , Yong Zhou , Dean Artis , Jiazhong Zhang
IPC分类号: A61K31/437 , C07D471/04 , A61P9/00 , A61P25/28 , A61P25/16 , A61P25/00 , A61P35/00 , A61P35/02
CPC分类号: C07D471/04 , C07D519/00
摘要: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
-
公开(公告)号:US20050288354A1
公开(公告)日:2005-12-29
申请号:US10937791
申请日:2004-09-08
申请人: James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
发明人: James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
IPC分类号: C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04 , A61K31/404
CPC分类号: C04B35/632 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04
摘要: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
-
公开(公告)号:US20060234306A1
公开(公告)日:2006-10-19
申请号:US11455165
申请日:2006-06-16
申请人: Dean Artis , David Jackson , Susan Keating , Maureen Beresini
发明人: Dean Artis , David Jackson , Susan Keating , Maureen Beresini
CPC分类号: G01N33/566 , C07K7/06 , G01N2333/70546 , G01N2500/00
摘要: A new method for assaying the ability of a compound to block the binding of an α4 integrin to a binding partner thereof provides a useful screening tool.
摘要翻译: 用于测定化合物阻断α4A整联蛋白与结合配偶体的结合的能力的新方法提供了有用的筛选工具。
-
公开(公告)号:US20050048573A1
公开(公告)日:2005-03-03
申请号:US10771833
申请日:2004-02-03
申请人: Dean Artis , Gideon Bollag , Graeme Card , Fernando Martin , Michael Milburn , Kam Zhang
发明人: Dean Artis , Gideon Bollag , Graeme Card , Fernando Martin , Michael Milburn , Kam Zhang
IPC分类号: C12N9/16 , G01N33/53 , G01N33/543 , G06F19/00
CPC分类号: C12N9/16 , C07K2299/00 , G16B15/00 , G16B20/00
摘要: A crystal structure of PDE5A is described that was determined by X-ray crystallography. The use of PDE5A crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate PDE5A.
摘要翻译: 描述了通过X射线晶体学确定的PDE5A的晶体结构。 例如,使用PDE5A晶体和结构信息可以用于鉴定分子支架和开发结合并调节PDE5A的配体。
-
公开(公告)号:US20050038246A1
公开(公告)日:2005-02-17
申请号:US10893134
申请日:2004-07-16
申请人: James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
发明人: James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
IPC分类号: C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D471/02 , C07D487/02
CPC分类号: C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译: 描述了对PPARs有活性的化合物,包括泛活性化合物。 还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。
-
9.
公开(公告)号:US08268858B2
公开(公告)日:2012-09-18
申请号:US11961901
申请日:2007-12-20
申请人: Guoxian Wu , Wayne Spevak , Songyuan Shi , Hanna Cho , Prabha N. Ibrahim , Chao Zhang , Shenghua Shi , Yong Zhou , Dean Artis , Jiazhong Zhang
发明人: Guoxian Wu , Wayne Spevak , Songyuan Shi , Hanna Cho , Prabha N. Ibrahim , Chao Zhang , Shenghua Shi , Yong Zhou , Dean Artis , Jiazhong Zhang
IPC分类号: A61K31/437 , C07D471/04
CPC分类号: C07D471/04 , C07D519/00
摘要: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译: 描述了对蛋白激酶有活性的化合物,以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。
-
公开(公告)号:US20070072904A1
公开(公告)日:2007-03-29
申请号:US11517573
申请日:2006-09-06
申请人: Jack Lin , Patrick Womack , Byunghun Lee , Shenghua Shi , Chao Zhang , Rebecca Zuckerman , Dean Artis , Prabha Ibrahim , Weiru Wang
发明人: Jack Lin , Patrick Womack , Byunghun Lee , Shenghua Shi , Chao Zhang , Rebecca Zuckerman , Dean Artis , Prabha Ibrahim , Weiru Wang
IPC分类号: A61K31/4709 , A61K31/404 , C07D409/02
CPC分类号: C07D409/14 , C07D209/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D491/04
摘要: Compounds are described that are active on PPARs, including pan-active compounds and compounds selective for any one or any two of PPARα, PPARα and PPARδ. Also described are methods of use of the compounds in treating various diseases.
摘要翻译: 描述了对PPARs有活性的化合物,包括对于PPARα,PPARα和PPARδ的任何一种或任何两种选择性的泛活性化合物和化合物。 还描述了使用这些化合物治疗各种疾病的方法。
-
-
-
-
-
-
-
-
-