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公开(公告)号:US06897225B1
公开(公告)日:2005-05-24
申请号:US10111110
申请日:2000-10-19
申请人: Ila Sircar , Marshall Morningstar , Paul Furth , Nicholas Smith , Bradley R. Teegarden , Ronald C. Griffith
发明人: Ila Sircar , Marshall Morningstar , Paul Furth , Nicholas Smith , Bradley R. Teegarden , Ronald C. Griffith
IPC分类号: C07D471/04 , C07D487/04 , C07D513/04 , A61K31/4188 , A61K31/4439 , A61P19/02
CPC分类号: C07D471/04 , C07D487/04 , C07D513/04
摘要: The present invention relates to a compound of the following formula: or a pharmaceutically acceptable salt thereof. Also disclosed are compositions containing the compound and methods of preparing and using the compounds. The compounds of the invention are useful in treating αLβ2 adhesion mediated conditions in a mammal.
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公开(公告)号:US07342012B2
公开(公告)日:2008-03-11
申请号:US11070335
申请日:2005-03-03
申请人: Ila Sircar , Paul Furth , Bradley R. Teegarden , Marshall Morningstar , Nicholas Smith , Ronald C. Griffith
发明人: Ila Sircar , Paul Furth , Bradley R. Teegarden , Marshall Morningstar , Nicholas Smith , Ronald C. Griffith
IPC分类号: C07D487/04 , A61K31/4985
CPC分类号: C07D471/04 , C07D487/04 , C07D513/04
摘要: The present invention relates to a compound of the following formula: or a pharmaceutically acceptable salt thereof. Also disclosed are compositions containing the compound and methods of preparing and using the compounds. The compounds of the invention are useful in treating αLβ2 adhesion mediated conditions in a mammal.
摘要翻译: 本发明涉及下式的化合物或其药学上可接受的盐。 还公开了含有该化合物的组合物和制备和使用该化合物的方法。 本发明的化合物可用于治疗哺乳动物中的α2 L 2β2/2粘附介导的病症。
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公开(公告)号:US06596752B1
公开(公告)日:2003-07-22
申请号:US10193137
申请日:2002-07-12
申请人: Thomas J. Lobl , Bradley R. Teegarden , Alexander Polinsky , Gilbert M. Rishton , Masafumi Yamagishi , Steven Tanis , Jed F. Fisher , Edward W. Thomas , Robert A. Chrusciel
发明人: Thomas J. Lobl , Bradley R. Teegarden , Alexander Polinsky , Gilbert M. Rishton , Masafumi Yamagishi , Steven Tanis , Jed F. Fisher , Edward W. Thomas , Robert A. Chrusciel
IPC分类号: A61K31415
CPC分类号: C07D213/81 , C07C229/46 , C07C233/60 , C07C233/63 , C07C233/83 , C07C233/87 , C07C235/40 , C07C235/64 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C255/29 , C07C255/46 , C07C259/08 , C07C271/22 , C07C271/28 , C07C275/26 , C07C275/42 , C07C311/21 , C07C311/64 , C07D207/16 , C07D209/20 , C07D213/64 , C07D213/82 , C07D217/26 , C07D233/64 , C07D295/185 , C07D295/192 , C07D307/68 , C07D333/24
摘要: The present invention relates to small molecules according to the formula [I]: which are potent inhibitors of &agr;4&bgr;1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing &agr;4&bgr;1 adhesion mediated conditions in a mammal such as a human.
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公开(公告)号:US06482849B1
公开(公告)日:2002-11-19
申请号:US09102584
申请日:1998-06-23
申请人: Thomas J. Lobl , Bradley R. Teegarden , Alexander Polinsky , Gilbert M. Rishton , Masafumi Yamagishi , Steven Tanis , Jed F. Fisher , Edward W. Thomas , Robert A. Chrusciel
发明人: Thomas J. Lobl , Bradley R. Teegarden , Alexander Polinsky , Gilbert M. Rishton , Masafumi Yamagishi , Steven Tanis , Jed F. Fisher , Edward W. Thomas , Robert A. Chrusciel
IPC分类号: A61K3127
CPC分类号: C07D213/81 , C07C229/46 , C07C233/60 , C07C233/63 , C07C233/83 , C07C233/87 , C07C235/40 , C07C235/64 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C255/29 , C07C255/46 , C07C259/08 , C07C271/22 , C07C271/28 , C07C275/26 , C07C275/42 , C07C311/21 , C07C311/64 , C07D207/16 , C07D209/20 , C07D213/64 , C07D213/82 , C07D217/26 , C07D233/64 , C07D295/185 , C07D295/192 , C07D307/68 , C07D333/24
摘要: The present invention relates to small molecules according to the formula [I]: which are potent inhibitors of &agr;4&bgr;1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing &agr;4&bgr;1 adhesion mediated conditions in a mammal such as a human.
摘要翻译: 本发明涉及根据式[I]的小分子:其是α4β1介导的对VCAM或CS-1的粘附的有效抑制剂,其可用于治疗或预防哺乳动物如人的α4β1粘附介导的病症 。
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