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公开(公告)号：US20240209015A1
公开(公告)日：2024-06-27
申请号：US18393220
申请日：2023-12-21
Applicant: Illumina, Inc.
Inventor： Antoine Francais , Elena Cressina , Angelica Mariani , Adam Culley , Anno Koetje , Xiaohai Liu , Xiaolin Wu , Kathryn Hattingh
IPC: C07H19/073 , C07H19/173 , C12Q1/6869
CPC classification number: C07H19/073 , C07H19/173 , C12Q1/6869
Abstract: Embodiments of the present disclosure relate to nucleotide and nucleoside molecules with acetal or allyl 3′ blocking groups. Also provided herein are methods to prepare such nucleotide and nucleoside molecules, and the uses of fully functionalized nucleotides containing the 3′ blocking groups for sequencing applications.
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公开(公告)号：US20240271206A1
公开(公告)日：2024-08-15
申请号：US18392547
申请日：2023-12-21
Applicant: Illumina, Inc.
Inventor： Antoine Francais , Elena Cressina , Kathryn Hattingh , Angelica Mariani , Xiaolin Wu , Xiaohai Liu
IPC: C12Q1/6874 , B01J23/44 , C12Q1/48 , C12Q1/6806 , C12Q1/6823
CPC classification number: C12Q1/6874 , B01J23/44 , C12Q1/485 , C12Q1/6806 , C12Q1/6823 , G01N2333/9126
Abstract: Embodiments of the present disclosure relate to nucleotides with 3′ allyl blocking groups. Also provided herein are methods of sequencing using nucleotides with 3′ allyl blocking groups described herein, and sequencing kits.
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公开(公告)号：US20240229131A1
公开(公告)日：2024-07-11
申请号：US18390322
申请日：2023-12-20
Applicant: Illumina, Inc.
Inventor： Angelica Mariani , Timothy Beech , Antoine Francais , Adyasha Panigrahi , Kathryn Hattingh , Elena Cressina
IPC: C12Q1/6874 , B01J23/44 , B01J31/14 , B01J31/24
CPC classification number: C12Q1/6874 , B01J23/44 , B01J31/146 , B01J31/24 , B01J2531/824
Abstract: The present application relates to compositions and methods for sequencing by synthesis. A blocking group of a nucleotide may be removed by a transition metal catalyst, the transition metal catalyst activated by a non-reducing ligand and a reducing agent.
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公开(公告)号：US20240182963A1
公开(公告)日：2024-06-06
申请号：US18392975
申请日：2023-12-21
Applicant: Illumina, Inc.
Inventor： Antoine Francais , Elena Cressina , Adam Culley , Angelica Mariani , Xiaolin Wu , Xiaohai Liu , Kathryn Hattingh
IPC: C12Q1/6869 , C07H19/06 , C07H19/16 , C07H21/00
CPC classification number: C12Q1/6869 , C07H19/06 , C07H19/16 , C07H21/00
Abstract: Embodiments of the present disclosure relate to nucleotide and nucleoside molecules with 3′ acetal, thiocarbamate or allyl blocking groups. Also provided herein are methods to prepare such nucleotide and nucleoside molecules, and the uses of fully functionalized nucleotides containing the 3′-OH blocking group for sequencing applications.
