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公开(公告)号：US09141913B2
公开(公告)日：2015-09-22
申请号：US12398107
申请日：2009-03-04
申请人： Ilya Kupershmidt , Qiaojuan Jane Su , Qingdi Liu , Satnam Alag , Suman Sundaresh
发明人： Ilya Kupershmidt , Qiaojuan Jane Su , Qingdi Liu , Satnam Alag , Suman Sundaresh
CPC分类号： G06F17/30598 , G06F17/30327 , G06F17/3053 , G06F19/18 , G06F19/22 , G06F19/28 , G06N99/005
摘要： The present invention relates to methods, systems and apparatus for capturing, integrating, organizing, navigating and querying large-scale data from high-throughput biological and chemical assay platforms. It provides a highly efficient meta-analysis infrastructure for performing research queries across a large number of studies and experiments from different biological and chemical assays, data types and organisms, as well as systems to build and add to such an infrastructure. According to various embodiments, methods, systems and interfaces for associating experimental data, features and groups of data related by structure and/or function with chemical, medical and/or biological terms in an ontology or taxonomy are provided. According to various embodiments, methods, systems and interfaces for filtering data by data source information are provided, allowing dynamic navigation through large amounts of data to find the most relevant results for a particular query.
摘要翻译： 本发明涉及用于从高通量生物化学测定平台捕获，整合，组织，导航和查询大规模数据的方法，系统和装置。 它提供了高效的荟萃分析基础设施，用于从不同的生物和化学测定，数据类型和生物体的大量研究和实验中进行研究查询，以及构建和添加到这样的基础设施的系统。 根据各种实施例，提供了用于将实验数据，特征和结构和/或功能相关的数据组与本体或分类学中的化学，医学和/或生物术语相关联的方法，系统和界面。 根据各种实施例，提供了用于通过数据源信息过滤数据的方法，系统和接口，允许通过大量数据的动态导航来找到特定查询的最相关结果。
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公开(公告)号：US20090222400A1
公开(公告)日：2009-09-03
申请号：US12398107
申请日：2009-03-04
申请人： Ilya Kupershmidt , Qiaojuan Jane Su , Qingdi Liu , Satnam Alag , Suman Sundaresh
发明人： Ilya Kupershmidt , Qiaojuan Jane Su , Qingdi Liu , Satnam Alag , Suman Sundaresh
CPC分类号： G06F17/30598 , G06F17/30327 , G06F17/3053 , G06F19/18 , G06F19/22 , G06F19/28 , G06N99/005
摘要： The present invention relates to methods, systems and apparatus for capturing, integrating, organizing, navigating and querying large-scale data from high-throughput biological and chemical assay platforms. It provides a highly efficient meta-analysis infrastructure for performing research queries across a large number of studies and experiments from different biological and chemical assays, data types and organisms, as well as systems to build and add to such an infrastructure. According to various embodiments, methods, systems and interfaces for associating experimental data, features and groups of data related by structure and/or function with chemical, medical and/or biological terms in an ontology or taxonomy are provided. According to various embodiments, methods, systems and interfaces for filtering data by data source information are provided, allowing dynamic navigation through large amounts of data to find the most relevant results for a particular query.
摘要翻译： 本发明涉及用于从高通量生物化学测定平台捕获，整合，组织，导航和查询大规模数据的方法，系统和装置。 它提供了高效的荟萃分析基础设施，用于从不同的生物和化学测定，数据类型和生物体的大量研究和实验中进行研究查询，以及构建和添加到这样的基础设施的系统。 根据各种实施例，提供了用于将实验数据，特征和结构和/或功能相关的数据组与本体或分类学中的化学，医学和/或生物术语相关联的方法，系统和界面。 根据各种实施例，提供了用于通过数据源信息过滤数据的方法，系统和接口，允许通过大量数据的动态导航来找到特定查询的最相关结果。
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公开(公告)号：US10275711B2
公开(公告)日：2019-04-30
申请号：US13588526
申请日：2012-08-17
摘要： The present invention relates to methods, systems and apparatus for capturing, integrating, organizing, navigating and querying large-scale data from high-throughput biological and chemical assay platforms. It provides a highly efficient meta-analysis infrastructure for performing research queries across a large number of studies and experiments from different biological and chemical assays, data types and organisms, as well as systems to build and add to such an infrastructure.
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4.发明授权公开(公告)号：US08364665B2
公开(公告)日：2013-01-29
申请号：US12234435
申请日：2008-09-19
申请人： Qiaojuan Jane Su , Ilya Kupershmidt
发明人： Qiaojuan Jane Su , Ilya Kupershmidt
CPC分类号： G06N5/02
摘要： The present invention relates to methods, systems and apparatus for capturing, integrating, organizing, navigating and querying large-scale data from high-throughput biological and chemical assay platforms. It provides a highly efficient meta-analysis infrastructure for performing research queries across a large number of studies and experiments from different biological and chemical assays, data types and organisms, as well as systems to build and add to such an infrastructure. In particular, aspects of the invention relate to integrating, organizing, navigating and querying “directional” data, such as gene expression profiles.
摘要翻译： 本发明涉及用于从高通量生物化学测定平台捕获，整合，组织，导航和查询大规模数据的方法，系统和装置。 它提供了高效的荟萃分析基础设施，用于从不同的生物和化学测定，数据类型和生物体的大量研究和实验中进行研究查询，以及构建和添加到这样的基础设施的系统。 特别地，本发明的方面涉及整合，组织，导航和查询定向数据，例如基因表达谱。
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公开(公告)号：US20100318528A1
公开(公告)日：2010-12-16
申请号：US12796545
申请日：2010-06-08
申请人： Ilya Kupershmidt , Qiaojuan Jane Su
发明人： Ilya Kupershmidt , Qiaojuan Jane Su
IPC分类号： G06F17/30
CPC分类号： G06F19/28 , G06F17/3053 , G06F17/30554 , G06F19/18 , G06F19/22 , G06F19/24
摘要： According to various embodiments, aspects of the invention provide a highly efficient meta-analysis infrastructure for performing research queries across a large number of studies and experiments from diverse sequencing technologies as well as different biological and chemical assays, data types and organisms, as well as systems to build and add to such an infrastructure. The methods, systems and apparatuses described enable combining orthogonal types of data and available public knowledge to elucidate mechanisms governing normal development, disease progression, as well as susceptibility of individuals to disease or response to drug treatments.
摘要翻译： 根据各种实施例，本发明的各方面提供了一种高效的荟萃分析基础设施，用于通过来自不同测序技术以及不同生物和化学测定，数据类型和生物体的大量研究和实验来执行研究查询，以及 建立和添加到这样的基础设施的系统。 所描述的方法，系统和装置能够组合正交类型的数据和可用的公共知识，以阐明管理正常发育，疾病进展以及个体对疾病或药物治疗反应的易感性的机制。
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公开(公告)号：US09183349B2
公开(公告)日：2015-11-10
申请号：US12796545
申请日：2010-06-08
申请人： Ilya Kupershmidt , Qiaojuan Jane Su
发明人： Ilya Kupershmidt , Qiaojuan Jane Su
CPC分类号： G06F19/28 , G06F17/3053 , G06F17/30554 , G06F19/18 , G06F19/22 , G06F19/24
摘要： According to various embodiments, aspects of the invention provide a highly efficient meta-analysis infrastructure for performing research queries across a large number of studies and experiments from diverse sequencing technologies as well as different biological and chemical assays, data types and organisms, as well as systems to build and add to such an infrastructure. The methods, systems and apparatuses described enable combining orthogonal types of data and available public knowledge to elucidate mechanisms governing normal development, disease progression, as well as susceptibility of individuals to disease or response to drug treatments.
摘要翻译： 根据各种实施例，本发明的各方面提供了一种高效的荟萃分析基础设施，用于通过来自不同测序技术以及不同的生物和化学测定，数据类型和生物体的大量研究和实验来执行研究查询，以及 建立和添加到这样的基础设施的系统。 所描述的方法，系统和装置能够组合正交类型的数据和可用的公共知识，以阐明管理正常发育，疾病进展以及个体对疾病或药物治疗反应的易感性的机制。
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公开(公告)号：US20150193576A9
公开(公告)日：2015-07-09
申请号：US12796545
申请日：2010-06-08
申请人： Ilya Kupershmidt , Qiaojuan Jane Su
发明人： Ilya Kupershmidt , Qiaojuan Jane Su
CPC分类号： G06F19/28 , G06F17/3053 , G06F17/30554 , G06F19/18 , G06F19/22 , G06F19/24
摘要： According to various embodiments, aspects of the invention provide a highly efficient meta-analysis infrastructure for performing research queries across a large number of studies and experiments from diverse sequencing technologies as well as different biological and chemical assays, data types and organisms, as well as systems to build and add to such an infrastructure. The methods, systems and apparatuses described enable combining orthogonal types of data and available public knowledge to elucidate mechanisms governing normal development, disease progression, as well as susceptibility of individuals to disease or response to drug treatments.
摘要翻译： 根据各种实施例，本发明的各方面提供了一种高效的荟萃分析基础设施，用于通过来自不同测序技术以及不同生物和化学测定，数据类型和生物体的大量研究和实验来执行研究查询，以及 建立和添加到这样的基础设施的系统。 所描述的方法，系统和装置能够组合正交类型的数据和可用的公共知识，以阐明管理正常发育，疾病进展以及个体对疾病或药物治疗反应的易感性的机制。
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公开(公告)号：US20130166599A1
公开(公告)日：2013-06-27
申请号：US13588526
申请日：2012-08-17
IPC分类号： G06F17/30
CPC分类号： G06N5/02
摘要： The present invention relates to methods, systems and apparatus for capturing, integrating, organizing, navigating and querying large-scale data from high-throughput biological and chemical assay platforms. It provides a highly efficient meta-analysis infrastructure for performing research queries across a large number of studies and experiments from different biological and chemical assays, data types and organisms, as well as systems to build and add to such an infrastructure.
摘要翻译： 本发明涉及用于从高通量生物化学测定平台捕获，整合，组织，导航和查询大规模数据的方法，系统和装置。 它提供了高效的荟萃分析基础设施，用于从不同的生物和化学测定，数据类型和生物体的大量研究和实验中进行研究查询，以及构建和添加到这样的基础设施的系统。
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公开(公告)号：US20130166320A1
公开(公告)日：2013-06-27
申请号：US13621756
申请日：2012-09-17
申请人： Ilya Kupershmidt , Qiaojuan Jane Su
发明人： Ilya Kupershmidt , Qiaojuan Jane Su
摘要： Provided herein are methods, systems and apparatus for querying and interpreting data derived from individual patients. The methods, systems and apparatus described herein can be used in clinical and research settings. Included are methods, systems and apparatus for identifying similar patients, germline DNA analysis, somatic tissue analysis, pathway-based therapy selection, prioritizing drugs, and querying a database to return patients and clinical attributes.
摘要翻译： 本文提供了用于查询和解释来自个体患者的数据的方法，系统和装置。 本文描述的方法，系统和装置可用于临床和研究设置。 包括用于鉴定类似患者的方法，系统和装置，种系DNA分析，体细胞组织分析，基于路径的治疗选择，优先药物和查询数据库以返回患者和临床特征。
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公开(公告)号：US08275737B2
公开(公告)日：2012-09-25
申请号：US11641539
申请日：2006-12-18
CPC分类号： G06N5/02
摘要： The present invention relates to methods, systems and apparatus for capturing, integrating, organizing, navigating and querying large-scale data from high-throughput biological and chemical assay platforms. It provides a highly efficient meta-analysis infrastructure for performing research queries across a large number of studies and experiments from different biological and chemical assays, data types and organisms, as well as systems to build and add to such an infrastructure.
摘要翻译： 本发明涉及用于从高通量生物化学测定平台捕获，整合，组织，导航和查询大规模数据的方法，系统和装置。 它提供了高效的荟萃分析基础设施，用于从不同的生物和化学测定，数据类型和生物体的大量研究和实验中进行研究查询，以及构建和添加到这样的基础设施的系统。
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