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1.发明申请公开(公告)号：US20220002755A1
公开(公告)日：2022-01-06
申请号：US17363942
申请日：2021-06-30
Applicant: Inscripta, Inc.
Inventor： Stephen Tanner , Michael Graige , Craig Struble , Nandini Krishnamurthy , Andrea Halweg-Edwards , Bryan Leland , Simon Cawley , Joshua Shorenstein , Timothy Shaver
Abstract: The present disclosure relates to compositions, methods, modules and automated integrated instrumentation to make auxiliary or ancillary edits—in addition to intended edits and immunizing edits—in cellular genomic nucleic acids in order to assess and improve nucleic acid-guided nuclease or nickase fusion editing.
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公开(公告)号：US20210108170A1
公开(公告)日：2021-04-15
申请号：US17069802
申请日：2020-10-13
Applicant: Inscripta, Inc.
Inventor： Stephen Tanner
Abstract: The present disclosure provides instruments, modules and methods for phenotypic readout for edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited and display a desired phenotype.
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公开(公告)号：US20220002725A1
公开(公告)日：2022-01-06
申请号：US17363884
申请日：2021-06-30
Applicant: Inscripta, Inc.
Inventor： Stephen Tanner , Michael Graige , Nandini Krishnamurthy , Craig Struble
IPC: C12N15/113 , C12N9/22 , C12N15/85
Abstract: The present disclosure relates to compositions, methods, modules and automated, integrated instrumentation to enable nucleic acid-guided nuclease or nickase fusion editing in cells and correlating the edits to the resulting cellular nucleic acid profile. In some embodiments, methylated bases in a repair template are substituted for unmethylated bases in the cellular target genome and in some embodiments, unmethylated bases are substituted for methylated bases in the cellular target genome.
