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1.发明授权公开(公告)号：US10978281B2
公开(公告)日：2021-04-13
申请号：US16798159
申请日：2020-02-21
发明人： Robert L. Moritz , Samuel Bader , Ulrike Kusebauch
摘要： The invention provides an unbiased method to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells by applying the unbiased determination technique of SWATH-MS or the biased technique of SRM-MS to a thermal shift assay to evaluate drug target interactions. In addition, the results created by SWATH-MS can be analyzed by SRM-MS in a biased manner to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells.
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公开(公告)号：US09726667B2
公开(公告)日：2017-08-08
申请号：US14641152
申请日：2015-03-06
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/567 , G01N33/554 , G01N33/569 , G01N33/00
CPC分类号： G01N33/5695 , G01N33/00
摘要： Point of care methods to detect the probability or status of tuberculosis infection in individuals by determining presence or absence of one or more peptide of SEQ ID NOS:1-22 in a biological fluid of a subject are described. These methods may be assays based on affinity reagents specifically reactive with these peptides.
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3.发明授权公开(公告)号：US11024492B2
公开(公告)日：2021-06-01
申请号：US15202378
申请日：2016-07-05
发明人： Robert L. Moritz , Samuel Bader , Ulrike Kusebauch
摘要： The invention provides an unbiased method to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells by applying the unbiased determination technique of SWATH-MS or the biased technique of SRM-MS to a thermal shift assay to evaluate drug target interactions. In addition, the results created by SWATH-MS can be analyzed by SRM-MS in a biased manner to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells.
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