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公开(公告)号：US11525036B2
公开(公告)日：2022-12-13
申请号：US17072771
申请日：2020-10-16
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
IPC分类号： A61K31/66 , A61K31/787 , A61P31/06 , C08G73/02 , A61K31/166 , C07C13/47
摘要： Techniques regarding killing of a pathogen with one or more ionene compositions having antimicrobial functionality are provided. For example, one or more embodiments can comprise a method, which can comprise contacting a Mycobacterium tuberculosis microbe with a chemical compound. The chemical compound can comprise an ionene unit. Also, the ionene unit can comprise a cation distributed along a molecular backbone. The ionene unit can have antimicrobial functionality. The method can further comprise electrostatically disrupting a membrane of the Mycobacterium tuberculosis microbe in response to the contacting.
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公开(公告)号：US11058110B2
公开(公告)日：2021-07-13
申请号：US16829370
申请日：2020-03-25
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
摘要： Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.
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公开(公告)号：US11007216B2
公开(公告)日：2021-05-18
申请号：US16531493
申请日：2019-08-05
发明人： James L. Hedrick , Yi Yan Yang , Xin Ding , Chuan Yang
IPC分类号： A61K31/765 , A61K33/242
摘要： Techniques regarding enhancing antimicrobial activity of antirheumatic agents by combination therapy are provided. For example, one or more embodiments described herein can regard a chemical composition comprising a polycarbonate polymer functionalized with a guanidinium functional group. The chemical composition can also comprise an antirheumatic agent, and the polycarbonate polymer can enhance an antimicrobial activity of the antirheumatic agent.
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公开(公告)号：US20190174754A1
公开(公告)日：2019-06-13
申请号：US15839415
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
摘要： Techniques regarding amine monomers that can form ionene compositions with antimicrobial functionality are provided. For example, one or more embodiments described herein can comprise a monomer, which can comprise a molecular backbone. The molecular backbone can comprise a norspermidine structure. The norspermidine structure can comprise a tertiary amino group. Also, the tertiary amino group can comprise a functional group, and an amino group of the norspermidine structure can be capable of being ionized.
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5.发明授权公开(公告)号：US10183099B2
公开(公告)日：2019-01-22
申请号：US14047056
申请日：2013-10-07
发明人： Xin Ding , James L. Hedrick , Chuan Yang , Yi Yan Yang
摘要： Catechol-bearing polycarbonates (catechol polymers) were prepared comprising i) a catechol repeat unit comprising a side chain catechol group, ii) a cationic repeat unit comprising a side chain cationic group selected from the group consisting of quaternary amine groups, quaternary phosphine groups, and combinations thereof, and iii) a PEG repeat unit comprising a side chain poly(ethylene oxide) group having a degree of polymerization of about 5 to about 30. The catechol polymers form antimicrobial and antifouling films on a variety of substrate surfaces, in particular silicone rubber.
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6.发明申请ANTIMICROBIAL AND ANTIFOULING CATECHOL-CONTAINING POLYCARBONATES FOR MEDICAL APPLICATIONS 审中-公开用于医疗应用的抗微生物和抗菌药含有聚碳酸酯公开(公告)号：US20150098976A1
公开(公告)日：2015-04-09
申请号：US14047056
申请日：2013-10-07
发明人： Xin Ding , James L. Hedrick , Chuan Yang , Yi Yan Yang
CPC分类号： A61L29/085 , A61L29/16 , A61L2300/404 , C08L69/00
摘要： Catechol-bearing polycarbonates (catechol polymers) were prepared comprising i) a catechol repeat unit comprising a side chain catechol group, ii) a cationic repeat unit comprising a side chain cationic group selected from the group consisting of quaternary amine groups, quaternary phosphine groups, and combinations thereof, and iii) a PEG repeat unit comprising a side chain poly(ethylene oxide) group having a degree of polymerization of about 5 to about 30. The catechol polymers form antimicrobial and antifouling films on a variety of substrate surfaces, in particular silicone rubber.
摘要翻译： 制备含儿茶酚的聚碳酸酯（儿茶酚聚合物），其包含i）包含侧链儿茶酚基团的儿茶酚重复单元，ii）包含侧链阳离子基团的阳离子重复单元，所述侧链阳离子基团选自季胺基，季膦基， 和其组合，以及iii）包含聚合度为约5至约30的侧链聚（环氧乙烷）基团的PEG重复单元。儿茶酚聚合物在各种基材表面上形成抗微生物和防污膜，特别是 硅橡胶。
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公开(公告)号：US20210299160A1
公开(公告)日：2021-09-30
申请号：US16832452
申请日：2020-03-27
发明人： James L. Hedrick , Yi Yan Yang , Nathaniel H. Park , Jiayu Leong , Chuan Yang , Xin Ding , Yiran Zhen , Cherylette Anne Alexander , Jye Yng Teo
IPC分类号： A61K31/785
摘要： Techniques regarding a chemical composition that can be utilized within one or more combination therapies to treat a microbial infection are provided. For example, one or more embodiments described herein can comprise a chemical composition that includes a first triblock polymer comprising a quaternary ammonium functionalized polycarbonate block and exhibiting anticancer activity via a lytic mechanism. The chemical composition can also include a second triblock polymer comprising a guanidinium functionalized polycarbonate block and exhibiting anticancer activity via a translocation mechanism.
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公开(公告)号：US11116844B2
公开(公告)日：2021-09-14
申请号：US16577142
申请日：2019-09-20
发明人： Dylan Boday , Wei Cheng , Jeannette M. Garcia , James Hedrick , Nathaniel H. Park , Rudy J. Wojtecki , Chuan Yang , YiYan Yang
IPC分类号： A61K47/60 , A61K47/69 , A61K31/785 , A61P35/00 , C08G65/332 , C08G65/00 , C08L71/02 , C08G64/18 , C08L71/00 , A61K9/107
摘要： Embodiments of the invention are directed to a macromolecular chemotherapeutic. A non-limiting example of the macromolecular chemotherapeutic includes a block copolymer. The block copolymer can include a water-soluble block, a cationic block, and a linker, wherein the linker is connected to the water-soluble bock and the charged block.
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公开(公告)号：US11028264B2
公开(公告)日：2021-06-08
申请号：US16531432
申请日：2019-08-05
发明人： Nathaniel H. Park , James L. Hedrick , Victoria A. Piunova , Gavin Jones , Yi Yan Yang , Pang Kern Jeremy Tan , Chuan Yang , Cherylette Anne Alexander
摘要： Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.
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10.发明申请公开(公告)号：US20210121498A1
公开(公告)日：2021-04-29
申请号：US17136709
申请日：2020-12-29
发明人： James L. Hedrick , Simone Bianco , Mark Kunitomi , Yi Yan Yang , Xin Ding , Chuan Yang , Zhen Chang Liang , Paola Florez de Sessions , Balamurugan Periaswamy
IPC分类号： A61K31/785 , A61P31/04
摘要： Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.
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