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公开(公告)号：US11191777B2
公开(公告)日：2021-12-07
申请号：US16013499
申请日：2018-06-20
IPC分类号： A61K31/765 , A61K31/155 , C08K5/31 , C08L69/00
摘要： Compositions and methods regarding antimicrobial guanidinium macromolecules with one or more targeting moieties for selectively targeting bacteria are provided. According to an embodiment, an antimicrobial macromolecule is provided that comprises a polymer backbone and one or more guanidinium moieties that extend from the polymer backbone. The antimicrobial macromolecule further comprises a targeting moiety that extends from the polymer backbone. The targeting moiety can comprise a substance favored for consumption by bacteria, such as a monosaccharide.
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公开(公告)号：US10653142B2
公开(公告)日：2020-05-19
申请号：US15839270
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
摘要： Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.
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公开(公告)号：US20230032345A1
公开(公告)日：2023-02-02
申请号：US17934964
申请日：2022-09-23
发明人： Nathaniel H. Park , Victoria A. Piunova , Dmitry Zubarev , James L. Hedrick , Yi Yan Yang , Eddy Wei Ping Tan
IPC分类号： C08G64/10 , C08G64/16 , B01J19/24 , C08G64/30 , C07D319/06
摘要： Techniques regarding post polymerization modifications to polycarbonate polymers via a flow reactor are provided. For example, one or more embodiments described herein can comprise a cyclic carbonate monomer that can be employed to facilitate polymerization of one or more polycarbonate platforms susceptible to post polymerization modification. For instance, one or more embodiments can regard a cyclic carbonate molecular backbone covalently bonded to an aryl halide functional group via in accordance with a chemical structure selected from the group consisting of: In the chemical structures, “R1” can be selected from the group consisting of a hydrogen atom and a functional group comprising a first alkyl group; “L” can represent a linkage group, comprising: a second alkyl group and an end group having at least one member selected from the group consisting of an oxygen atom and a nitrogen atom; and “A” can represent the aryl halide functional group.
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公开(公告)号：US11028264B2
公开(公告)日：2021-06-08
申请号：US16531432
申请日：2019-08-05
发明人： Nathaniel H. Park , James L. Hedrick , Victoria A. Piunova , Gavin Jones , Yi Yan Yang , Pang Kern Jeremy Tan , Chuan Yang , Cherylette Anne Alexander
摘要： Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.
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公开(公告)号：US10667514B2
公开(公告)日：2020-06-02
申请号：US15839415
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
IPC分类号： A01N25/04 , A01N25/10 , A01N27/00 , A01N33/04 , A01N43/08 , A01N47/30 , A01N37/02 , A01N33/12 , A61Q17/00
摘要： Techniques regarding amine monomers that can form ionene compositions with antimicrobial functionality are provided. For example, one or more embodiments described herein can comprise a monomer, which can comprise a molecular backbone. The molecular backbone can comprise a norspermidine structure. The norspermidine structure can comprise a tertiary amino group. Also, the tertiary amino group can comprise a functional group, and an amino group of the norspermidine structure can be capable of being ionized.
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公开(公告)号：US20200146296A1
公开(公告)日：2020-05-14
申请号：US16738517
申请日：2020-01-09
发明人： Victoria A. Piunova , Noah Frederick Fine Nathel , James L. Hedrick , Yi Yan Yang , Willy Chin , Zhi Xiang Voo
摘要： Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.
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公开(公告)号：US20190174755A1
公开(公告)日：2019-06-13
申请号：US15839388
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang , Mu San Zhang
CPC分类号： A01N37/18 , A01N33/12 , A01N43/50 , C08G69/40 , C08G2230/00 , C08L101/00 , A01N25/10
摘要： Techniques regarding ionene and/or polyionene compositions with antimicrobial functionality and enhanced hydrophilicity are provided. For example, one or more embodiments can regard a chemical compound that can comprise an ionene unit, which can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. The ionene unit can have antimicrobial functionality. Further, the chemical compound can comprise a hydrophilic functional group covalently bonded to the ionene unit. Also, the chemical compound can have carbohydrate mimetic functionality.
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公开(公告)号：US20190174747A1
公开(公告)日：2019-06-13
申请号：US15839402
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang
摘要： Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
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公开(公告)号：US20190159456A1
公开(公告)日：2019-05-30
申请号：US15824250
申请日：2017-11-28
发明人： Willy Chin , James L. Hedrick , Noah Frederick Fine Nathel , Victoria A. Piunova , Zhi Xiang Voo , Yi Yan Yang
IPC分类号： A01N47/06 , C08G64/42 , C09D5/14 , C09D169/00
摘要： Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.
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公开(公告)号：US11006628B2
公开(公告)日：2021-05-18
申请号：US16744868
申请日：2020-01-16
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang
IPC分类号： A01N25/10 , A01N37/26 , A01N43/50 , A01N47/44 , C07C279/10 , C08L79/02 , C08G69/26 , C08G73/02 , C08L101/00 , A61Q17/00
摘要： Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
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