公开(公告)号：US08828686B2

公开(公告)日：2014-09-09

申请号：US13769144

申请日：2013-02-15

申请人： Intrexon Corporation

发明人： Thomas D. Reed ,  Richard E. Peterson ,  Charles E. Reed ,  Joan Mazzarelli Sopczynski ,  Bethany L. Merenick ,  Jonathan Carson ,  Catherine L. Keaty ,  Elena Tasheva

IPC分类号： C12N15/63 ,  C12N1/20 ,  C07K14/00 ,  C07K14/81 ,  C07K14/75 ,  C07K14/78 ,  C12N9/72 ,  C12N9/44

CPC分类号： C07K14/001 ,  C07K14/75 ,  C07K14/78 ,  C07K14/8132 ,  C12N9/2451 ,  C12N9/6459 ,  C12N9/6462 ,  C12Y302/01099 ,  C12Y304/21069 ,  C12Y304/21073

摘要： The invention relates to mammalian PAI-I ligands and modulators. In particular, the invention relates to polypeptides, polypeptide compositions and polynucleotides that encode polypeptides that are ligands and/or modulators of PAI-I. The invention also relates to polyligands that are homopolyligands or heteropolyligands that modulate PAI-I activity. The invention also relates to ligands and polyligands localized to a region of a cell. The invention also relates to localization tethers and promoter sequences that can be used to provide spatial control of the PAI-I ligands and polyligands. The invention also relates to inducible gene switches that can be used to provide temporal control of the PAI-I ligands and polyligands. The invention also relates to methods of treating or preventing atherosclerosis. The invention also relates to methods of treating or preventing fibrosis.

摘要翻译： 本发明涉及哺乳动物PAI-1配体和调节剂。 具体地，本发明涉及编码作为PAI-1的配体和/或调节剂的多肽的多肽，多肽组合物和多核苷酸。 本发明还涉及作为调节PAI-1活性的均聚配体或杂多糖的聚合配体。 本发明还涉及位于细胞区域的配体和聚合配体。 本发明还涉及可用于提供PAI-1配体和聚合配体的空间控制的定位系链和启动子序列。 本发明还涉及可用于提供PAI-1配体和聚合配体的时间控制的可诱导基因开关。 本发明还涉及治疗或预防动脉粥样硬化的方法。 本发明还涉及治疗或预防纤维化的方法。