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1.发明申请公开(公告)号：US20180126007A1
公开(公告)日：2018-05-10
申请号：US15637624
申请日：2017-06-29
Applicant: Intrexon Corporation
Inventor： Bethany Lynn MERENICK , Robert P. Beech , Thomas D. Reed , Anna P. Tretiakova , Richard E. Peterson
IPC: A61K48/00 , A61K31/7088 , C12N15/63 , C12N15/85
CPC classification number: A61K48/0066 , A61K31/7088 , A61K35/12 , C12N15/635 , C12N15/85 , C12N2510/02 , C12N2830/002 , C12N2830/15
Abstract: The present invention relates to methods and compositions for treating, ameliorating or preventing a disease or disorder in a subject by introducing into cells of the subject a therapeutic gene switch construct that controls expression of one or more therapeutic products.
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Patent Agency Ranking
公开(公告)号：US09724430B2
公开(公告)日：2017-08-08
申请号：US14864265
申请日：2015-09-24
Applicant: Intrexon Corporation
Inventor： Bethany Lynn Merenick , Robert P. Beech , Thomas D. Reed , Anna P. Tretiakova , Richard E. Peterson
IPC: C07H21/04 , C12N15/00 , C12N15/63 , A61K48/00 , A61K31/7088 , C12N15/85 , A01K67/00 , A61K35/12
CPC classification number: A61K48/0066 , A61K31/7088 , A61K35/12 , C12N15/635 , C12N15/85 , C12N2510/02 , C12N2830/002 , C12N2830/15
Abstract: The present invention relates to methods and compositions for treating, ameliorating or preventing a disease or disorder in a subject by introducing into cells of the subject a therapeutic gene switch construct that controls expression of one or more therapeutic products.
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公开(公告)号：US08828686B2
公开(公告)日：2014-09-09
申请号：US13769144
申请日：2013-02-15
Applicant: Intrexon Corporation
Inventor： Thomas D. Reed , Richard E. Peterson , Charles E. Reed , Joan Mazzarelli Sopczynski , Bethany L. Merenick , Jonathan Carson , Catherine L. Keaty , Elena Tasheva
CPC classification number: C07K14/001 , C07K14/75 , C07K14/78 , C07K14/8132 , C12N9/2451 , C12N9/6459 , C12N9/6462 , C12Y302/01099 , C12Y304/21069 , C12Y304/21073
Abstract: The invention relates to mammalian PAI-I ligands and modulators. In particular, the invention relates to polypeptides, polypeptide compositions and polynucleotides that encode polypeptides that are ligands and/or modulators of PAI-I. The invention also relates to polyligands that are homopolyligands or heteropolyligands that modulate PAI-I activity. The invention also relates to ligands and polyligands localized to a region of a cell. The invention also relates to localization tethers and promoter sequences that can be used to provide spatial control of the PAI-I ligands and polyligands. The invention also relates to inducible gene switches that can be used to provide temporal control of the PAI-I ligands and polyligands. The invention also relates to methods of treating or preventing atherosclerosis. The invention also relates to methods of treating or preventing fibrosis.
Abstract translation: 本发明涉及哺乳动物PAI-1配体和调节剂。 具体地，本发明涉及编码作为PAI-1的配体和/或调节剂的多肽的多肽，多肽组合物和多核苷酸。 本发明还涉及作为调节PAI-1活性的均聚配体或杂多糖的聚合配体。 本发明还涉及位于细胞区域的配体和聚合配体。 本发明还涉及可用于提供PAI-1配体和聚合配体的空间控制的定位系链和启动子序列。 本发明还涉及可用于提供PAI-1配体和聚合配体的时间控制的可诱导基因开关。 本发明还涉及治疗或预防动脉粥样硬化的方法。 本发明还涉及治疗或预防纤维化的方法。
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公开(公告)号：US10314926B2
公开(公告)日：2019-06-11
申请号：US15637624
申请日：2017-06-29
Applicant: Intrexon Corporation
Inventor： Bethany Lynn Merenick , Robert P. Beech , Thomas D. Reed , Anna P. Tretiakova , Richard E. Peterson
IPC: C07H21/04 , C12N15/00 , A61K48/00 , A61K31/7088 , C12N15/85 , C12N15/63 , A01K67/00 , A61K35/12
Abstract: The present invention relates to methods and compositions for treating, ameliorating or preventing a disease or disorder in a subject by introducing into cells of the subject a therapeutic gene switch construct that controls expression of one or more therapeutic products.
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5.发明申请公开(公告)号：US20160114059A1
公开(公告)日：2016-04-28
申请号：US14864265
申请日：2015-09-24
Applicant: Intrexon Corporation
Inventor： Bethany Lynn MERENICK , Robert P. Beech , Thomas D. Reed , Anna P. Tretiakova , Richard E. Peterson
CPC classification number: A61K48/0066 , A61K31/7088 , A61K35/12 , C12N15/635 , C12N15/85 , C12N2510/02 , C12N2830/002 , C12N2830/15
Abstract: The present invention relates to methods and compositions for treating, ameliorating or preventing a disease or disorder in a subject by introducing into cells of the subject a therapeutic gene switch construct that controls expression of one or more therapeutic products.
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公开(公告)号：US20130267022A1
公开(公告)日：2013-10-10
申请号：US13769144
申请日：2013-02-15
Applicant: Intrexon Corporation
Inventor： Thomas D. Reed , Richard E. Peterson , Charles E. Reed , Joan Mazzarelli Sopczynski , Bethany L. Merenick , Jonathan Carson , Catherine L. Bair , Elena Tasheva
IPC: C07K14/00
CPC classification number: C07K14/001 , C07K14/75 , C07K14/78 , C07K14/8132 , C12N9/2451 , C12N9/6459 , C12N9/6462 , C12Y302/01099 , C12Y304/21069 , C12Y304/21073
Abstract: The invention relates to mammalian PAI-I ligands and modulators. In particular, the invention relates to polypeptides, polypeptide compositions and polynucleotides that encode polypeptides that are ligands and/or modulators of PAI-I. The invention also relates to polyligands that are homopolyligands or heteropolyligands that modulate PAI-I activity. The invention also relates to ligands and polyligands localized to a region of a cell. The invention also relates to localization tethers and promoter sequences that can be used to provide spatial control of the PAI-I ligands and polyligands. The invention also relates to inducible gene switches that can be used to provide temporal control of the PAI-I ligands and polyligands. The invention also relates to methods of treating or preventing atherosclerosis. The invention also relates to methods of treating or preventing fibrosis.
Abstract translation: 本发明涉及哺乳动物PAI-1配体和调节剂。 具体地，本发明涉及编码作为PAI-1的配体和/或调节剂的多肽的多肽，多肽组合物和多核苷酸。 本发明还涉及作为调节PAI-1活性的均聚配体或杂多糖的聚合配体。 本发明还涉及位于细胞区域的配体和聚合配体。 本发明还涉及可用于提供PAI-1配体和聚合配体的空间控制的定位系链和启动子序列。 本发明还涉及可用于提供PAI-1配体和聚合配体的时间控制的可诱导基因开关。 本发明还涉及治疗或预防动脉粥样硬化的方法。 本发明还涉及治疗或预防纤维化的方法。
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