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    Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use
    1.
    发明申请
    Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use 有权
    包括FV分子的抗体和对间皮素具有高结合亲和力的免疫缀合物及其使用方法

    公开(公告)号：US20050214304A1

    公开(公告)日：2005-09-29

    申请号：US10973718

    申请日：2004-10-25

    申请人： Ira Pastan ,  Partha Chowdhury

    发明人： Ira Pastan ,  Partha Chowdhury

    IPC分类号： A61K47/48 ,  C07K16/30 ,  G01N33/574 ,  A61K39/395 ,  C07H21/04 ,  C12N1/21 ,  C12N15/74

    CPC分类号： G01N33/57492 ,  A61K47/6829 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/3069 ,  C07K2317/565 ,  G01N33/57449

    摘要： Mesothelin ins a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and immunoconjugates employing them. Also described are diagnostic and therapeutic methods using the antibodies. The anti-mesothelin antibodies are well-suited for the diagnosis and treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin.

    摘要翻译： 间皮素含有存在于卵巢癌，间皮瘤和其他几种类型人类癌症表面的分化抗原。 因为在正常组织中，间皮素仅存在于间皮细胞上，它代表抗体介导的细胞毒性剂递送的良好靶标。 本发明涉及抗间皮素抗体，包括对间皮素具有特别高亲和力的Fv分子和使用它们的免疫缀合物。 还描述了使用抗体的诊断和治疗方法。 抗间皮素抗体非常适合于诊断和治疗卵巢癌，胃癌，鳞状细胞癌，间皮瘤等表达间皮素的恶性细胞癌。

    Antibodies that specifically bind to GMAD
    3.
    发明申请
    Antibodies that specifically bind to GMAD 审中-公开
    特异性结合GMAD的抗体

    公开(公告)号：US20100292441A1

    公开(公告)日：2010-11-18

    申请号：US12320513

    申请日：2009-01-28

    申请人： Kevin P. Baker ,  Vivian R. Albert ,  Partha Chowdhury

    发明人： Kevin P. Baker ,  Vivian R. Albert ,  Partha Chowdhury

    IPC分类号： C07K16/18 ,  C12N5/16

    CPC分类号： A61K51/1018 ,  A61K47/6843 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/26 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to GMAD. Such antibodies have uses, for example, in the prevention and treatment of both insulin- and non insulin-dependent diabetes mellitus (i.e. Type I and Type II diabetes) and other related disorders. The invention also relates to nucleic acid molecules encoding anti-GMAD antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially diabetes and other related disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to GMAD.

    摘要翻译： 本发明涉及免疫特异性结合GMAD的抗体和相关分子。 这样的抗体具有例如用于预防和治疗胰岛素和非胰岛素依赖型糖尿病（即I型和II型糖尿病）和其它相关疾病。 本发明还涉及编码抗GMAD抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是糖尿病和其它相关病症的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段 或其变体，或免疫特异性结合GMAD的相关分子。

    Method and apparatus for response enabled messaging
    4.
    发明授权
    Method and apparatus for response enabled messaging 有权
    响应启用消息的方法和设备

    公开(公告)号：US07783713B2

    公开(公告)日：2010-08-24

    申请号：US11876717

    申请日：2007-10-22

    申请人： Venkat Easwar ,  Partha Chowdhury ,  Chirag Bakshi ,  Amit Agarwal

    发明人： Venkat Easwar ,  Partha Chowdhury ,  Chirag Bakshi ,  Amit Agarwal

    IPC分类号： G06F15/16

    CPC分类号： G06Q10/107

    摘要： A method and apparatus for creating associations between messages in a stateless system. The method comprises adding a unique identification to a notification message at a gateway, and upon receiving a response from a user, identifying the unique identification within the response, and utilizing the unique identification to associate the response with the notification message.

    摘要翻译： 一种在无状态系统中创建消息之间的关联的方法和装置。 该方法包括向网关上的通知消息添加唯一标识，以及在接收到来自用户的响应时，识别响应内的唯一标识，以及利用唯一标识将响应与通知消息相关联。

    Antibodies that specifically bind to GMAD
    6.
    发明申请
    Antibodies that specifically bind to GMAD 失效
    特异性结合GMAD的抗体

    公开(公告)号：US20050069542A1

    公开(公告)日：2005-03-31

    申请号：US10935290

    申请日：2004-09-08

    申请人： Kevin Baker ,  Vivian Albert ,  Partha Chowdhury

    发明人： Kevin Baker ,  Vivian Albert ,  Partha Chowdhury

    IPC分类号： A61K47/48 ,  A61K51/10 ,  C07K16/18 ,  C07K16/26 ,  C12P21/08 ,  A61K39/395 ,  C07K16/28

    CPC分类号： A61K51/1018 ,  A61K47/6843 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/26 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to GMAD. Such antibodies have uses, for example, in the prevention and treatment of both insulin- and non insulin-dependent diabetes mellitus (i.e. Type I and Type II diabetes) and other related disorders. The invention also relates to nucleic acid molecules encoding anti-GMAD antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially diabetes and other related disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to GMAD.

    摘要翻译： 本发明涉及免疫特异性结合GMAD的抗体和相关分子。 这样的抗体具有例如用于预防和治疗胰岛素和非胰岛素依赖型糖尿病（即I型和II型糖尿病）和其它相关疾病。 本发明还涉及编码抗GMAD抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是糖尿病和其它相关病症的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段 或其变体，或免疫特异性结合GMAD的相关分子。

    Antibodies that specifically bind to GMAD
    8.
    发明授权
    Antibodies that specifically bind to GMAD 失效
    特异性结合GMAD的抗体

    公开(公告)号：US07550569B2

    公开(公告)日：2009-06-23

    申请号：US10935290

    申请日：2004-09-08

    申请人： Kevin P. Baker ,  Vivian R. Albert ,  Partha Chowdhury

    发明人： Kevin P. Baker ,  Vivian R. Albert ,  Partha Chowdhury

    IPC分类号： C12P21/08 ,  C07K16/00

    CPC分类号： A61K51/1018 ,  A61K47/6843 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/26 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to GMAD. Such antibodies have uses, for example, in the prevention and treatment of both insulin- and non insulin-dependent diabetes mellitus (i.e. Type I and Type II diabetes) and other related disorders. The invention also relates to nucleic acid molecules encoding anti-GMAD antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially diabetes and other related disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to GMAD.

    摘要翻译： 本发明涉及免疫特异性结合GMAD的抗体和相关分子。 这样的抗体具有例如用于预防和治疗胰岛素和非胰岛素依赖型糖尿病（即I型和II型糖尿病）和其它相关疾病。 本发明还涉及编码抗GMAD抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是糖尿病和其它相关病症的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段 或其变体，或免疫特异性结合GMAD的相关分子。