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公开(公告)号：US08934975B2
公开(公告)日：2015-01-13
申请号：US13576485
申请日：2011-02-01
申请人： Irit Yaniv , Walid Haddad , Paul V. Goode, Jr. , Harold Lebovitz , Ricardo Aviv , Benny Rousso , Shlomo Ben-Haim
发明人： Irit Yaniv , Walid Haddad , Paul V. Goode, Jr. , Harold Lebovitz , Ricardo Aviv , Benny Rousso , Shlomo Ben-Haim
CPC分类号： A61N1/36139 , A61N1/0509 , A61N1/36007 , A61N1/36053 , A61N1/36085
摘要： Apparatus (18) for treating a human patient, which includes one or more electrode contact surfaces (100), which are configured to be applied to a fundus (22) of the patient. A control unit (90) is configured to drive the one or more electrode contact surfaces (100) to apply an electrical signal to the fundus (22) that chronically improves a blood glucose level of the patient, in order to treat the patient, without calculating an impedance of tissue of the fundus (22) based on a sensed parameter that varies in response to the electrical signal, for detecting eating by the patient or a characteristic of food eaten by the patient. Other embodiments are also described.
摘要翻译： 用于治疗人类患者的装置（18），其包括被配置为施加到患者的眼底（22）的一个或多个电极接触表面（100）。 控制单元（90）被配置为驱动所述一个或多个电极接触表面（100）以将电信号施加到眼底（22），所述电信号长期改善患者的血糖水平，以便治疗患者，而没有 基于响应于电信号变化的感测参数，用于检测患者的进食或患者吃的食物的特征，计算眼底组织的阻抗（22）。 还描述了其它实施例。
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公开(公告)号：US20130030503A1
公开(公告)日：2013-01-31
申请号：US13576485
申请日：2011-02-01
申请人： IRIT Yaniv , Walid Haddad , Paul V. Goode , Harold Lebovitz , Ricardo Aviv , Benny Rousso , Shlomo Ben-Haim
发明人： IRIT Yaniv , Walid Haddad , Paul V. Goode , Harold Lebovitz , Ricardo Aviv , Benny Rousso , Shlomo Ben-Haim
CPC分类号： A61N1/36139 , A61N1/0509 , A61N1/36007 , A61N1/36053 , A61N1/36085
摘要： Apparatus (18) for treating a human patient, which includes one or more electrode contact surfaces (100), which are configured to be applied to a fundus (22) of the patient. A control unit (90) is configured to drive the one or more electrode contact surfaces (100) to apply an electrical signal to the fundus (22) that chronically improves a blood glucose level of the patient, in order to treat the patient, without calculating an impedance of tissue of the fundus (22) based on a sensed parameter that varies in response to the electrical signal, for detecting eating by the patient or a characteristic of food eaten by the patient. Other embodiments are also described.
摘要翻译： 用于治疗人类患者的装置（18），其包括被配置为施加到患者的眼底（22）的一个或多个电极接触表面（100）。 控制单元（90）被配置为驱动所述一个或多个电极接触表面（100）以将电信号施加到眼底（22），所述电信号长期改善患者的血糖水平，以便治疗患者，而没有 基于响应于电信号变化的感测参数，用于检测患者的进食或患者吃的食物的特征，计算眼底组织的阻抗（22）。 还描述了其它实施例。
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公开(公告)号：US20070179556A1
公开(公告)日：2007-08-02
申请号：US10561491
申请日：2004-06-20
申请人： Shlomo Ben Haim , Shai Policker , Ricardo Aviv , Ofer Glasberg
发明人： Shlomo Ben Haim , Shai Policker , Ricardo Aviv , Ofer Glasberg
IPC分类号： A61N1/32
CPC分类号： A61K49/00 , A61B5/053 , A61B5/1116 , A61B5/14539 , A61B5/4238 , A61B5/6871 , A61F5/0026 , A61F5/0036 , A61N1/36007
摘要： A method is provided for detecting a change in posture of a subject. An electrical impedance is measured between two or more sites on a stomach (20) of the subject, and an impedance signal is generated responsive thereto. The change in posture is detected by performing a posture analysis of the impedance signal. A method is also provided for treating a subject. The method includes applying an electrical signal to a site of the subject selected from the list consisting of: a colon (402) of the subject, and a distal small intestine (408) of the subject. The signal is configured to stimulate cells of the subject to increase secretion of glucagon-like-peptide-1 (GLP-1) or PYY, or to decrease secretion of ghrelin, in order to treat the subject.
摘要翻译： 提供一种用于检测被检体的姿势变化的方法。 在受试者的胃（20）上的两个或更多个部位之间测量电阻抗，并且响应于此产生阻抗信号。 通过进行阻抗信号的姿势分析来检测姿势的变化。 还提供了一种治疗受试者的方法。 该方法包括将电信号施加到从包括受试者的结肠（402）和受试者的远端小肠（408）的列表中选择的对象的部位。 信号被配置为刺激受试者的细胞以增加胰高血糖素样肽-1（GLP-1）或PYY的分泌，或者降低生长素释放肽的分泌，以便治疗受试者。
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公开(公告)号：US07502649B2
公开(公告)日：2009-03-10
申请号：US10561491
申请日：2004-06-20
申请人： Shlomo Ben-Haim , Shai Policker , Ricardo Aviv , Ofer Glasberg
发明人： Shlomo Ben-Haim , Shai Policker , Ricardo Aviv , Ofer Glasberg
IPC分类号： A61N1/08
CPC分类号： A61K49/00 , A61B5/053 , A61B5/1116 , A61B5/14539 , A61B5/4238 , A61B5/6871 , A61F5/0026 , A61F5/0036 , A61N1/36007
摘要： A method is provided for detecting a change in posture of a subject. An electrical impedance is measured between two or more sites on a stomach (20) of the subject, and an impedance signal is generated responsive thereto. The change in posture is detected by performing a posture analysis of the impedance signal. A method is also provided for treating a subject. The method includes applying an electrical signal to a site of the subject selected from the list consisting of: a colon (402) of the subject, and a distal small intestine (408) of the subject. The signal is configured to stimulate cells of the subject to increase secretion of glucagon-like-peptide-1 (GLP-1) or PYY, or to decrease secretion of ghrelin, in order to treat the subject.
摘要翻译： 提供一种用于检测被检体的姿势变化的方法。 在受试者的胃（20）上的两个或更多个部位之间测量电阻抗，并且响应于此产生阻抗信号。 通过进行阻抗信号的姿势分析来检测姿势的变化。 还提供了一种治疗受试者的方法。 该方法包括将电信号施加到从包括受试者的结肠（402）和受试者的远端小肠（408）的列表中选择的对象的部位。 信号被配置为刺激受试者的细胞以增加胰高血糖素样肽-1（GLP-1）或PYY的分泌，或者降低生长素释放肽的分泌，以便治疗受试者。
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5.发明申请公开(公告)号：US20070239216A9
公开(公告)日：2007-10-11
申请号：US10116201
申请日：2002-04-03
申请人： Itzik Shemer , Bella Felzen , Nissim Darvish , Yuval Mika , Walid Haddad , Ricardo Aviv , Yaakov Haham
发明人： Itzik Shemer , Bella Felzen , Nissim Darvish , Yuval Mika , Walid Haddad , Ricardo Aviv , Yaakov Haham
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3628 , A61N1/368
摘要： According to a method and device for modulating intracellular calcium concentration in biological tissue, a stimulation probe is applied to the tissue, a non-excitatory stimulation pulse is generated, and the pulse is conveyed to the stimulation probe. In one embodiment concerning cardiac tissue, a stimulation probe is applied to a patient's heart, a signal is received from at least one sensor responsive to the patient's cardiac muscle activity, a non-excitatory stimulation pulse responsive to the signal is generated, and the pulse is conveyed to the stimulation probe.
摘要翻译： 根据用于调节生物组织中细胞内钙浓度的方法和装置，将刺激探针施加到组织，产生非兴奋性刺激脉冲，并将脉冲输送到刺激探针。 在关于心脏组织的一个实施例中，将刺激探针应用于患者的心脏，响应于患者的心肌活动从至少一个传感器接收信号，产生响应于该信号的非兴奋性刺激脉冲，并且脉冲 被传送到刺激探针。
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公开(公告)号：US20090118797A1
公开(公告)日：2009-05-07
申请号：US11573722
申请日：2005-08-18
申请人： Anat Kliger , Shai Policker , Ricardo Aviv
发明人： Anat Kliger , Shai Policker , Ricardo Aviv
CPC分类号： A61N1/08 , A61N1/36007
摘要： Gastric apparatus (18) is provided, including one or more sensors (70, 72, 74), adapted to generate respective sensor signals responsive to activity of a gastrointestinal tract of a subject. A control unit (90) is adapted to receive and analyze the sensor signals and to determine that an eating event has occurred, responsive to at least one of the sensor signals and a threshold. The control unit identifies an aspect of at least one of the sensor signals deriving from rhythmic activity of the gastrointestinal tract that is not indicative of current eating by the subject, and modifies the threshold responsive to the aspect of the signals that derives from activity that is not indicative of current eating. For some applications, the control unit is adapted to modify the threshold if the aspect is indicative of a migrating motor complex (MMC). Other embodiments are also described.
摘要翻译： 提供了胃装置（18），其包括一个或多个传感器（70,72,74），适于产生响应受试者的胃肠道活动的相应传感器信号。 控制单元（90）适于接收和分析传感器信号并响应于至少一个传感器信号和阈值来确定进食事件已经发生。 控制单元识别出来自胃肠道节奏活动的至少一个传感器信号的一个方面，其不指示受试者目前的饮食，并且根据来自活动的信号的方面修改阈值 不表示目前的饮食。 对于某些应用，如果该方面指示迁移电动机复合体（MMC），则控制单元适于修改阈值。 还描述了其它实施例。
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公开(公告)号：US07330753B2
公开(公告)日：2008-02-12
申请号：US10475198
申请日：2002-04-16
申请人： Shai Policker , Ricardo Aviv , Ophir Biton
发明人： Shai Policker , Ricardo Aviv , Ophir Biton
IPC分类号： A61B5/053
CPC分类号： A61B5/42 , A61B5/04884 , A61B5/053 , A61B5/076 , A61B5/1107 , A61B5/4023 , A61B5/4233 , A61N1/36007 , Y10S128/903 , Y10S128/92
摘要： Diet evaluation gastric apparatus (18) is provided, which detects when a patient (10) swallows, and detects the type and amount of matter ingested. The apparatus includes electrodes (74, 100) adapted to be coupled to the fundus and antrum of the patient and to measure electrical and mechanical activity therein, and a control unit (90) to analyze such electrical and mechanical activity and optionally apply electrical energy to modify the activity of tissue of the patient.
摘要翻译： 提供饮食评价胃装置（18），其检测患者（10）何时吞咽，并检测摄入的物质的类型和数量。 该装置包括适于耦合到患者的眼底和窦并测量其中的电和机械活动的电极（74,100），以及控制单元（90），用于分析这种电气和机械活动并且可选地将电能施加到 修改患者组织的活动。
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公开(公告)号：US20070299320A1
公开(公告)日：2007-12-27
申请号：US11848555
申请日：2007-08-31
申请人： Shai Policker , Ricardo Aviv , Ophir Biton
发明人： Shai Policker , Ricardo Aviv , Ophir Biton
IPC分类号： A61B5/00
CPC分类号： A61B5/42 , A61B5/04884 , A61B5/053 , A61B5/076 , A61B5/1107 , A61B5/4023 , A61B5/4233 , A61N1/36007 , Y10S128/903 , Y10S128/92
摘要： Diet evaluation gastric apparatus (18) is provided, which detects when a patient (10) swallows, and detects the type and amount of matter ingested. The apparatus includes electrodes (74, 100) adapted to be coupled to the fundus and antrum of the patient and to measure electrical and mechanical activity therein, and a control unit (90) to analyze such electrical and mechanical activity and optionally apply electrical energy to modify the activity of tissue of the patient.
摘要翻译： 提供饮食评价胃装置（18），其检测患者（10）何时吞咽，并检测摄入的物质的类型和数量。 该装置包括适于耦合到患者的眼底和窦并测量其中的电和机械活动的电极（74,100），以及控制单元（90），用于分析这种电气和机械活动并且可选地将电能施加到 修改患者组织的活动。
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公开(公告)号：US08612016B2
公开(公告)日：2013-12-17
申请号：US11573722
申请日：2005-08-18
申请人： Anat Kliger , Shai Policker , Ricardo Aviv
发明人： Anat Kliger , Shai Policker , Ricardo Aviv
CPC分类号： A61N1/08 , A61N1/36007
摘要： Gastric apparatus is provided, including one or more sensors, adapted to generate respective sensor signals responsive to activity of a gastrointestinal tract of a subject. A control unit is configured with an eating detection threshold selected from the group consisting of: a predetermined threshold, and a threshold determined during a calibration procedure. The control unit is adapted to receive and analyze the sensor signals, and identify an aspect of at least one of the sensor signals indicative of periodic activity of the gastrointestinal tract. The control unit modifies the eating detection threshold responsive to identifying the aspect of the signals that is indicative of the periodic activity, and determines that an eating event has occurred responsive to the modified eating detection threshold and at least one of the analyzed sensor signals. Other embodiments are also described.
摘要翻译： 提供了胃装置，包括一个或多个传感器，其适于产生响应受试者的胃肠道活动的相应传感器信号。 控制单元配置有从由以下组成的组中选择的进食检测阈值：预定阈值和在校准过程期间确定的阈值。 控制单元适于接收和分析传感器信号，并且识别指示胃肠道周期性活动的至少一个传感器信号的方面。 控制单元响应于识别指示周期性活动的信号的方面来修改进食检测阈值，并且根据修改的进食检测阈值和所分析的传感器信号中的至少一个确定进食事件已经发生。 还描述了其它实施例。
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公开(公告)号：US07840269B2
公开(公告)日：2010-11-23
申请号：US11848555
申请日：2007-08-31
申请人： Shai Policker , Ricardo Aviv , Ophir Biton
发明人： Shai Policker , Ricardo Aviv , Ophir Biton
IPC分类号： A61B5/053
CPC分类号： A61B5/42 , A61B5/04884 , A61B5/053 , A61B5/076 , A61B5/1107 , A61B5/4023 , A61B5/4233 , A61N1/36007 , Y10S128/903 , Y10S128/92
摘要： Diet evaluation gastric apparatus (18) is provided, which detects when a patient (10) swallows, and detects the type and amount of matter ingested. The apparatus includes electrodes (74, 100) adapted to be coupled to the fundus and antrum of the patient and to measure electrical and mechanical activity therein, and a control unit (90) to analyze such electrical and mechanical activity and optionally apply electrical energy to modify the activity of tissue of the patient.
摘要翻译： 提供饮食评价胃装置（18），其检测患者（10）何时吞咽，并检测摄入的物质的类型和数量。 该装置包括适于耦合到患者的眼底和窦并测量其中的电和机械活动的电极（74,100），以及控制单元（90），用于分析这种电气和机械活动并且可选地将电能施加到 修改患者组织的活动。
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