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34 条记录 (耗时 0.028 秒)

    Aminoglycoside compounds, processes for production thereof, and pharamaceutical composition containing the same
    8.
    发明授权
    Aminoglycoside compounds, processes for production thereof, and pharamaceutical composition containing the same 失效
    氨基糖苷类化合物，其制备方法和含有该组合物的药用组合物

    公开(公告)号：US4855287A

    公开(公告)日：1989-08-08

    申请号：US903137

    申请日：1986-09-03

    申请人： Isamu Watanabe ,  Kazuhiro Kamiya ,  Takahiro Torii ,  Toshihito Mori

    发明人： Isamu Watanabe ,  Kazuhiro Kamiya ,  Takahiro Torii ,  Toshihito Mori

    IPC分类号： C07H15/224 ,  A61K9/02 ,  A61K9/16 ,  A61K9/22 ,  A61K9/48 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61P31/04 ,  C07H15/12

    CPC分类号： C07H15/12 ,  Y02P20/55

    摘要： An aminoglycoside compound represented by the following formula (I) ##STR1## wherein one of R.sub.1 and R.sub.2 represents a hydrogen atom, and the other represents a methyl group,R.sub.3 represents a hydrogen atom or a hydroxyl group,R.sub.4 represents a hydrogen atom, a hydroxyl group or a methoxy group,n represents an integer of 1 to 5,W represents a divalent group of the formula --NHCO.fwdarw., --CONH.fwdarw., --COO.fwdarw., or --S.fwdarw. in which .fwdarw. represents a bond to X, andX represents (i) a single bond or (ii) a C.sub.1 -C.sub.20 trivalent acyclic saturated hydrocarbon group, andY and Z are separately defined according to the cases (i) and (ii) above, and its pharmaceutically acceptable acid addition salt; and a process for producing the above aminoglycoside compound. A pharmaceutical composition comprising the above aminoglycoside compound is useful as an antibiotic.

    摘要翻译： 由下式（I）表示的氨基糖苷类化合物其中R 1和R 2中的一个表示氢原子，另一个表示甲基，R 3表示氢原子或羟基，R 4表示氢 原子，羟基或甲氧基，n表示1〜5的整数，W表示式-NHCO-，-CONH - ， - COO-或-S-的二价基团，其中 - >表示与X的键，X表示（i）单键或（ii）C1-C20三价无环饱和烃基，Y和Z根据上述情况（i）和（ii）分别定义， 及其药学上可接受的酸加成盐; 以及上述氨基糖苷类化合物的制造方法。 包含上述氨基糖苷类化合物的药物组合物可用作抗生素。

    Fortimicin aminoglycosides, process for production thereof, and use thereof
    9.
    发明授权
    Fortimicin aminoglycosides, process for production thereof, and use thereof 失效
    百古霉素氨基糖苷类，其制备方法及其用途

    公开(公告)号：US4255421A

    公开(公告)日：1981-03-10

    申请号：US85058

    申请日：1979-10-12

    申请人： Isamu Watanabe ,  Akio Iwasaki ,  Toshihito Mori

    发明人： Isamu Watanabe ,  Akio Iwasaki ,  Toshihito Mori

    IPC分类号： C07H15/224 ,  A61K31/71 ,  C07H15/22

    CPC分类号： C07H15/224

    摘要： Novel aminoglycosides of the following formula ##STR1## wherein R.sub.1 and R.sub.2 are identical or different and each represents a hydrogen atom or a methyl group, R.sub.3 represents a hydrogen atom or an optionally substituted aminoacyl group having 2 to 4 carbon atoms in the acyl moiety, and when all of R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms, the methylamino group at the 4-position is not oriented trans to the hydroxyl groups at the 3- and 5-positions; and acid addition salts thereof, which are useful as antibiotics; and process for producing compounds containing the same.

    摘要翻译： 下列通式的新型氨基糖苷类其中R 1和R 2相同或不同，各自表示氢原子或甲基，R 3表示酰基部分中的氢原子或任选取代的具有2至4个碳原子的氨基酰基， 当R 1，R 2和R 3全部为氢原子时，4-位上的甲基氨基不反向在3-和5-位羟基上; 和其酸加成盐，其可用作抗生素; 以及制备含有该化合物的化合物的方法。

    Process for production of antibiotics and novel antibiotics produced thereby
    10.
    发明授权
    Process for production of antibiotics and novel antibiotics produced thereby 失效
    生产抗生素的方法和由此生产的新型抗生素

    公开(公告)号：US4425430A

    公开(公告)日：1984-01-10

    申请号：US281898

    申请日：1981-07-09

    申请人： Akio Iwasaki ,  Takeo Deushi ,  Isamu Watanabe ,  Toshihito Mori

    发明人： Akio Iwasaki ,  Takeo Deushi ,  Isamu Watanabe ,  Toshihito Mori

    IPC分类号： C07H15/224 ,  C12P19/48 ,  A01N63/02 ,  C12R1/01

    CPC分类号： C07H15/224 ,  C12P19/48 ,  C12R1/01 ,  Y10S435/822

    摘要： A process for producing an antibiotic, which comprises cultivating an antibiotic KA-6606-producing strain of an genus Saccharopolyspora in a nutrient culture medium, isolating the antibiotic KA-6606-containing substance from the culture broth, and separating from the resulting antibiotic KA-6606-containing substance at least one antibiotic selected from the group consisting of antibiotic KA-6606 VII, KA-6606 VIII, KA-6606 IX, KIA-6606 X, KA-6606 XI, KA-6606 XII, KA-6606 XIII, KA-6606 XIV, KA-6606 XV, KIA-6606 XVI and KA-6606 XVII; and novel antibiotics KA-6606 XII, XIII and XV to XVII.

    摘要翻译： 一种生产抗生素的方法，其包括在营养培养基中培养产生抗生素KA-6606的产酵菌属菌株，从培养液中分离含抗生素KA-6606的物质，并从得到的抗生素KA- 含有6606的物质，选自抗生素KA-6606 VII，KA-6606 VIII，KA-6606 IX，KIA-6606X，KA-6606 XI，KA-6606 XII，KA-6606 XIII， KA-6606 XIV，KA-6606 XV，KIA-6606 XVI和KA-6606 XVII; 和新型抗生素KA-6606 XII，XIII和XV至XVII。