-
公开(公告)号：US07521438B1
公开(公告)日：2009-04-21
申请号：US10089449
申请日：2000-09-26
申请人： Istvan Szelenyi , Hildegard Kuss , Sabine Heer , Juergen Engel
发明人： Istvan Szelenyi , Hildegard Kuss , Sabine Heer , Juergen Engel
IPC分类号： A61K31/56
CPC分类号： A61K9/0075 , A61K31/167 , A61K31/56 , A61K45/06 , Y10S514/826 , A61K2300/00
摘要： The invention relates to a novel combination of a soft steroid, in particular loteprednol, and at least one β2 adrenoceptor agonist for the simultaneous, sequential or separate treatment of allergies and/or airway disorders, medicaments comprising the combination, processes for the production of such medicaments and the use of the novel combination for the production of medicaments for the simultaneous, sequential or separate treatment of allergies and/or airway disorders.
摘要翻译： 本发明涉及软类固醇，特别是碘苯醇和与过敏和/或气道障碍的同时，连续或分开治疗的至少一种β2肾上腺素受体激动剂的新组合，包含该组合的药物， 药物和用于生产用于同时，连续或分开地治疗过敏和/或气道障碍的药物的新型组合的用途。
-
2.再颁专利Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation 失效羟基吲哚，它们用作磷酸二酯酶4的抑制剂及其制备方法公开(公告)号：USRE38624E1
公开(公告)日：2004-10-12
申请号：US10176435
申请日：2002-09-19
申请人： Norbert Hofgen , Ute Egerland , Hildegard Kuss , Degenhard Marx , Stefan Szelenyi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
发明人： Norbert Hofgen , Ute Egerland , Hildegard Kuss , Degenhard Marx , Stefan Szelenyi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
IPC分类号： A61K314439
CPC分类号： C07D209/22 , C07D209/24 , C07D401/12
摘要： The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
-
公开(公告)号：US20070161671A1
公开(公告)日：2007-07-12
申请号：US11714466
申请日：2007-03-06
申请人： Nobert Hofgen , Hildegard Kuss , Matthias Olbrich , Ute Egerland , Chris Rundfeldt , Karin Steinike , Rudolf Schindler
发明人： Nobert Hofgen , Hildegard Kuss , Matthias Olbrich , Ute Egerland , Chris Rundfeldt , Karin Steinike , Rudolf Schindler
IPC分类号： A61K31/4745 , A61K31/4439 , C07D471/02 , C07D403/02
CPC分类号： C07D471/04
摘要： The invention relates to substituted 7-azaindoles, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.
摘要翻译： 本发明涉及取代的7-氮杂吲哚，其制备方法，包含这些化合物的药物制剂以及作为磷酸二酯酶4抑制剂的这些化合物的药物用途，作为治疗可受抑制影响的病症的活性成分 的磷酸二酯酶4活性，特别是在本发明化合物的免疫活性细胞（例如巨噬细胞和淋巴细胞）中。
-
4.发明授权7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them 失效7-氮杂吲哚，它们作为磷酸二酯酶4的抑制剂的用途，以及它们的合成方法公开(公告)号：US07683074B2
公开(公告)日：2010-03-23
申请号：US12075312
申请日：2008-03-10
申请人： Norbert Höfgen , Ute Egerland , Thomas Kronbach , Degenhard Marx , Stefan Szelenyi , Hildegard Kuss , Emmanuel Polymeropoulos
发明人： Norbert Höfgen , Ute Egerland , Thomas Kronbach , Degenhard Marx , Stefan Szelenyi , Hildegard Kuss , Emmanuel Polymeropoulos
IPC分类号： A61K31/4745
CPC分类号： C07D471/04
摘要： 7-azaindoles inhibit phosphodiesterase 4 (PDE4). Methods for preparing these compounds and methods of treating arthritis and other conditions with the compounds are also provided.
摘要翻译： 7-氮杂吲哚抑制磷酸二酯酶4（PDE4）。 还提供了制备这些化合物的方法和用化合物治疗关节炎和其它病症的方法。
-
5.发明申请Use of the non-opiate analgesic drug flupirtine of the treatment of overactive bladder and associated diseases including urge incontinence, urinary flow problems as a result of prostate hyperplasia and irritable bowl syndrome 失效使用非阿片类镇痛药物氟吡汀治疗膀胱过度活动和相关疾病，包括急迫性尿失禁，前列腺增生和肠易激综合征导致的尿流问题公开(公告)号：US20060173052A1
公开(公告)日：2006-08-03
申请号：US11336406
申请日：2006-01-20
申请人： Chris Rundfeldt , Hildegard Kuss , Regina Draheim
发明人： Chris Rundfeldt , Hildegard Kuss , Regina Draheim
IPC分类号： A61K31/44
CPC分类号： A61K31/44 , Y10S514/867
摘要： The present invention is directed to the prevention, reversal and medical treatment of lower urinary tract dysfunction including bladder instability and other related diseases as described below including urinary flow problems, urgency and incontinence as a result of prostate hyperplasia (BPH) and to the prevention, reversal and medical treatment of irritable bowl syndrome (IBS) with special focus on the diarrhea-predominant and mixed diarrhea-constipation type IBS, both in human beings and animals.
摘要翻译： 本发明涉及如下所述的包括膀胱不稳定性和其他相关疾病在内的下尿路功能障碍的预防，逆转和治疗，包括由前列腺增生（BPH）引起的尿流问题，紧急性和失禁以及预防， 急性肠易激综合征（IBS）的逆转和治疗，特别关注腹泻主要和混合型腹泻便秘型IBS，人类和动物。
-
公开(公告)号：US07211583B2
公开(公告)日：2007-05-01
申请号：US10826136
申请日：2004-04-16
申请人： Nobert Höfgen , Hildegard Kuss , Matthias Olbrich , Ute Egerland , Chris Rundfeldt , Karin Steinike , Rudolf Schindler
发明人： Nobert Höfgen , Hildegard Kuss , Matthias Olbrich , Ute Egerland , Chris Rundfeldt , Karin Steinike , Rudolf Schindler
IPC分类号： C07D471/02 , A61K31/437
CPC分类号： C07D471/04
摘要： The invention relates to substituted 7-azaindoles, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.
摘要翻译： 本发明涉及取代的7-氮杂吲哚，其制备方法，包含这些化合物的药物制剂以及作为磷酸二酯酶4抑制剂的这些化合物的药物用途，作为治疗可受抑制影响的病症的活性成分 的磷酸二酯酶4活性，特别是在本发明化合物的免疫活性细胞（例如巨噬细胞和淋巴细胞）中。
-
7.发明授权7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same 失效7-氮杂吲哚，其作为磷酸二酯酶4抑制剂的用途及其制备方法公开(公告)号：US07169787B2
公开(公告)日：2007-01-30
申请号：US10399051
申请日：2001-10-25
申请人： Norbert Höfgen , Ute Egerland , Thomas Kronbach , Degenhard Marx , Stefan Szelenyi , Hildegard Kuss , Emmanuel Polymeropoulos
发明人： Norbert Höfgen , Ute Egerland , Thomas Kronbach , Degenhard Marx , Stefan Szelenyi , Hildegard Kuss , Emmanuel Polymeropoulos
IPC分类号： A61K31/437 , A61K31/5377 , C07D295/02 , C07D221/04 , C07D221/02
CPC分类号： C07D471/04
摘要： The invention relates to new 7-azaindoles, their use as inhibitors of phosphodiesterase 4 and to methods for their synthesis.
摘要翻译： 本发明涉及新的7-氮杂吲哚，它们用作磷酸二酯酶4的抑制剂及其合成方法。
-
8.发明申请Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them 审中-公开新型羟基吲哚，它们用作磷酸二酯酶4的抑制剂，以及它们的制备方法公开(公告)号：US20070093531A1
公开(公告)日：2007-04-26
申请号：US11606696
申请日：2006-11-30
申请人： Norbert Hofgen , Hildegard Kuss , Ute Egerland , Chris Rundfeldt , Helge Hartenhauer , Antje Gasparic
发明人： Norbert Hofgen , Hildegard Kuss , Ute Egerland , Chris Rundfeldt , Helge Hartenhauer , Antje Gasparic
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D209/42 , C07D209/22
摘要： The invention relates to substituted 4- or/and 7-hydroxyindoles, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active compounds for treating diseases which can be influenced by using the compounds according to the invention to inhibit phosphodiesterase 4 activity in immunocompetent cells (e.g. macrophages and lympho-cytes).
摘要翻译： 本发明涉及取代的4-或/和7-羟基吲哚，其制备方法，包括这些化合物的药物制剂和作为磷酸二酯酶4抑制剂的这些化合物的药物用途，作为用于治疗疾病的活性化合物 可以通过使用根据本发明的化合物来抑制免疫活性细胞（例如巨噬细胞和淋巴细胞）中的磷酸二酯酶4活性的影响。
-
9.发明授权Hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them 失效羟基吲哚，它们作为磷酸二酯酶4的抑制剂的用途及其制备方法公开(公告)号：US07166637B2
公开(公告)日：2007-01-23
申请号：US10714568
申请日：2003-11-13
申请人： Norbert Höfgen , Hildegard Kuss , Ute Egerland , Chris Rundfeldt , Helge Hartenhauer , Antje Gasparic
发明人： Norbert Höfgen , Hildegard Kuss , Ute Egerland , Chris Rundfeldt , Helge Hartenhauer , Antje Gasparic
IPC分类号： A61K31/404 , C07D209/04
CPC分类号： C07D209/42 , C07D209/22
摘要： The invention relates to substituted 4- or/and 7-hydroxyindoles, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active compounds for treating diseases which can be influenced by using the compounds according to the invention to inhibit phosphodiesterase 4 activity in immunocompetent cells (e.g. macrophages and lymphocytes).
摘要翻译： 本发明涉及取代的4-或/和7-羟基吲哚，其制备方法，包括这些化合物的药物制剂和作为磷酸二酯酶4抑制剂的这些化合物的药物用途，作为用于治疗疾病的活性化合物 可以通过使用根据本发明的化合物来抑制免疫活性细胞（例如巨噬细胞和淋巴细胞）中的磷酸二酯酶4活性的影响。
-
10.发明申请7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them 失效7-氮杂吲哚，它们作为磷酸二酯酶4的抑制剂的用途，以及它们的合成方法公开(公告)号：US20060258700A1
公开(公告)日：2006-11-16
申请号：US11329400
申请日：2006-01-10
申请人： Norbert Hofgen , Ute Egerland , Thomas Kronbach , Degenhard Marx , Stefan Szelenyi , Hildegard Kuss , Emmanuel Polymeropoulos
发明人： Norbert Hofgen , Ute Egerland , Thomas Kronbach , Degenhard Marx , Stefan Szelenyi , Hildegard Kuss , Emmanuel Polymeropoulos
IPC分类号： A61K31/4745
CPC分类号： C07D471/04
摘要： 7-azaindoles inhibit phosphodiesterase 4 (PDE4). Methods for preparing these compounds are also provided.
摘要翻译： 7-氮杂吲哚抑制磷酸二酯酶4（PDE4）。 还提供了制备这些化合物的方法。
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.022 秒)