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10 条记录 (耗时 0.021 秒)

    Combination of loteprednol and β2-adrenoceptor agonists
    1.
    发明授权
    Combination of loteprednol and β2-adrenoceptor agonists 失效
    碘苯醇和β2-肾上腺素受体激动剂的组合

    公开(公告)号：US07521438B1

    公开(公告)日：2009-04-21

    申请号：US10089449

    申请日：2000-09-26

    申请人： Istvan Szelenyi ,  Hildegard Kuss ,  Sabine Heer ,  Juergen Engel

    发明人： Istvan Szelenyi ,  Hildegard Kuss ,  Sabine Heer ,  Juergen Engel

    IPC分类号： A61K31/56

    CPC分类号： A61K9/0075 ,  A61K31/167 ,  A61K31/56 ,  A61K45/06 ,  Y10S514/826 ,  A61K2300/00

    摘要： The invention relates to a novel combination of a soft steroid, in particular loteprednol, and at least one β2 adrenoceptor agonist for the simultaneous, sequential or separate treatment of allergies and/or airway disorders, medicaments comprising the combination, processes for the production of such medicaments and the use of the novel combination for the production of medicaments for the simultaneous, sequential or separate treatment of allergies and/or airway disorders.

    摘要翻译： 本发明涉及软类固醇，特别是碘苯醇和与过敏和/或气道障碍的同时，连续或分开治疗的至少一种β2肾上腺素受体激动剂的新组合，包含该组合的药物， 药物和用于生产用于同时，连续或分开地治疗过敏和/或气道障碍的药物的新型组合的用途。

    Process for producing sterile suspensions of slightly soluble basic peptide complexes, sterile suspensions of slightly soluble basic peptide complexes, pharmaceutical formulations containing them, and the use thereof as medicaments
    3.
    发明申请
    Process for producing sterile suspensions of slightly soluble basic peptide complexes, sterile suspensions of slightly soluble basic peptide complexes, pharmaceutical formulations containing them, and the use thereof as medicaments 失效
    用于生产微溶碱性肽复合物的无菌悬浮液，微溶性碱性肽复合物的无菌悬浮液，含有它们的药物制剂及其作为药物的用途的方法

    公开(公告)号：US20060135405A1

    公开(公告)日：2006-06-22

    申请号：US11304548

    申请日：2005-12-16

    申请人： Matthias Rischer ,  Horst Mueller ,  Karl Werner ,  Juergen Engel

    发明人： Matthias Rischer ,  Horst Mueller ,  Karl Werner ,  Juergen Engel

    IPC分类号： A61K38/16

    CPC分类号： A61K9/19 ,  A61K9/0019 ,  A61K9/10 ,  A61K31/19 ,  A61K38/09 ,  A61K47/26 ,  G06F19/00 ,  A61K2300/00

    摘要： The present invention provides a novel process for producing sterile suspensions of slightly soluble basic peptide complexes. The present invention further provides a novel process for producing sterile lyophilizates of slightly soluble basic peptide complexes. In addition, a novel process for producing sterile suspensions suitable for the parenteral administration of slightly soluble basic peptide complexes is provided. The invention moreover provides sterile suspensions and sterile lyophilizates of slightly soluble basic peptide complexes, and pharmaceutical formulations comprising them. The provided sterile suspensions, sterile lyophilizates and pharmaceutical formulations comprising them are particularly suitable for use in a parenteral dosage form as medicaments for the treatment and prophylaxis of diseases and pathological states in mammals, especially in humans.

    摘要翻译： 本发明提供了一种生产微溶性碱性肽复合物的无菌悬浮液的新方法。 本发明还提供了用于生产微溶性碱性肽复合物的无菌冻干物的新方法。 此外，提供了一种用于生产适于胃肠外施用微溶性碱性肽复合物的无菌悬浮液的新方法。 此外，本发明提供了无菌悬浮液和微溶性碱性肽复合物的无菌冻干物，以及包含它们的药物制剂。 提供的无菌悬浮液，无菌冻干物和包含它们的药物制剂特别适用于肠胃外剂型，作为用于治疗和预防哺乳动物，特别是人的疾病和病理状态的药物。

    Process for producing sterile suspensions of slightly soluble basic peptide complexes, sterile suspensions of slightly soluble basic peptide complexes, pharmaceutical formulations containing them, and the use thereof as medicaments
    5.
    发明授权
    Process for producing sterile suspensions of slightly soluble basic peptide complexes, sterile suspensions of slightly soluble basic peptide complexes, pharmaceutical formulations containing them, and the use thereof as medicaments 失效
    用于生产微溶碱性肽复合物的无菌悬浮液，微溶性碱性肽复合物的无菌悬浮液，含有它们的药物制剂及其作为药物的用途的方法

    公开(公告)号：US07871977B2

    公开(公告)日：2011-01-18

    申请号：US11304548

    申请日：2005-12-16

    申请人： Matthias Rischer ,  Horst Mueller ,  Karl Werner ,  Juergen Engel

    发明人： Matthias Rischer ,  Horst Mueller ,  Karl Werner ,  Juergen Engel

    IPC分类号： A01N37/18 ,  A61K38/00

    CPC分类号： A61K9/19 ,  A61K9/0019 ,  A61K9/10 ,  A61K31/19 ,  A61K38/09 ,  A61K47/26 ,  G06F19/00 ,  A61K2300/00

    摘要： The present invention provides a novel process for producing sterile suspensions of slightly soluble basic peptide complexes. The present invention further provides a novel process for producing sterile lyophilizates of slightly soluble basic peptide complexes. In addition, a novel process for producing sterile suspensions suitable for the parenteral administration of slightly soluble basic peptide complexes is provided. The invention moreover provides sterile suspensions and sterile lyophilizates of slightly soluble basic peptide complexes, and pharmaceutical formulations comprising them. The provided sterile suspensions, sterile lyophilizates and pharmaceutical formulations comprising them are particularly suitable for use in a parenteral dosage form as medicaments for the treatment and prophylaxis of diseases and pathological states in mammals, especially in humans.

    摘要翻译： 本发明提供了一种生产微溶性碱性肽复合物的无菌悬浮液的新方法。 本发明还提供了用于生产微溶性碱性肽复合物的无菌冻干物的新方法。 此外，提供了一种用于生产适于胃肠外施用微溶性碱性肽复合物的无菌悬浮液的新方法。 此外，本发明提供了无菌悬浮液和微溶性碱性肽复合物的无菌冻干物，以及包含它们的药物制剂。 提供的无菌悬浮液，无菌冻干物和包含它们的药物制剂特别适用于肠胃外剂型，作为用于治疗和预防哺乳动物，特别是人的疾病和病理状态的药物。

    NOVEL ALKYL PHOSPHOLIPID DERIVATIVES WITH REDUCED CYTOTOXICITY AND USES THEREOF
    7.
    发明申请
    NOVEL ALKYL PHOSPHOLIPID DERIVATIVES WITH REDUCED CYTOTOXICITY AND USES THEREOF 审中-公开
    具有降低细胞毒性的新型碱金属磷酸衍生物及其用途

    公开(公告)号：US20070167408A1

    公开(公告)日：2007-07-19

    申请号：US11612506

    申请日：2006-12-19

    申请人： Daniel PERRISSOUD ,  Mathias Pietras ,  Juergen Engel

    发明人： Daniel PERRISSOUD ,  Mathias Pietras ,  Juergen Engel

    IPC分类号： A61K31/675

    CPC分类号： A61K31/675 ,  Y02A50/463

    摘要： The present invention provides novel alkyl phospholipid derivatives with reduced cytotoxicity that are useful for treating various diseases and/or pathophysiological conditions in mammals, preferably humans, that are caused by microorganisms, in particular bacteria, fungi, protozoa and/or viruses. Such alkyl phospholipids can be employed as single drugs or in the course of combination therapies and can also be used for the treatment of tumors.

    摘要翻译： 本发明提供了具有降低的细胞毒性的新型烷基磷脂衍生物，其可用于治疗由微生物特别是细菌，真菌，原生动物和/或病毒引起的哺乳动物，优选人类的各种疾病和/或病理生理条件。 这种烷基磷脂可以作为单一药物使用，也可以在组合疗法中使用，也可用于治疗肿瘤。

    Use of LHRH antagonists for intermittent treatments
    8.
    发明授权
    Use of LHRH antagonists for intermittent treatments 有权
    使用LHRH拮抗剂进行间歇治疗

    公开(公告)号：US08273716B2

    公开(公告)日：2012-09-25

    申请号：US12394374

    申请日：2009-02-27

    申请人： Juergen Engel

    发明人： Juergen Engel

    IPC分类号： A61K38/06 ,  A61P35/00 ,  C07D209/82

    CPC分类号： A61K31/5355 ,  A61K31/403 ,  A61K31/416 ,  A61K31/4412 ,  A61K31/4439 ,  A61K31/519

    摘要： The invention relates to methods of treatment or prophylaxis of physiological and/or pathological conditions with at least one LHRH antagonist, in particular at least one peptidomimetic LHRH antagonist such that the at least one LHRH antagonist is administered in a dose, which does not cause chemical (hormonal) castration.

    摘要翻译： 本发明涉及用至少一种LHRH拮抗剂，特别是至少一种拟肽LHRH拮抗剂治疗或预防生理和/或病理状况的方法，使得至少一种LHRH拮抗剂以不引起化学物质的剂量施用 （激素）去势。