公开(公告)号：US07317099B2

公开(公告)日：2008-01-08

申请号：US10168365

申请日：2000-12-23

申请人： Ivan Labat ,  Y. Tom Tang ,  Radoje T. Drmanac ,  Chenghua Liu ,  Juhi Lee ,  Nancy K. Mize ,  John Childs ,  Cheng-Chi Chao

发明人： Ivan Labat ,  Y. Tom Tang ,  Radoje T. Drmanac ,  Chenghua Liu ,  Juhi Lee ,  Nancy K. Mize ,  John Childs ,  Cheng-Chi Chao

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N5/10 ,  C12N1/15 ,  C12N15/21

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/475

摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

摘要翻译： 本发明提供由这样的多核苷酸编码的新型多核苷酸和多肽，其对应于新型人分泌的干细胞生长因子样多肽的突变体或其变体。 这些多核苷酸包含从人胎肝脾，卵巢，成人脑，肺肿瘤，脊髓，子宫颈，卵巢，内皮细胞，脐带，淋巴细胞，肺成纤维细胞，胎儿脑和睾丸制备的cDNA文库中分离的核酸序列。 本发明的其它方面包括含有用于产生新的人分泌的干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

公开(公告)号：US20060074044A1

公开(公告)日：2006-04-06

申请号：US11283290

申请日：2005-11-18

申请人： Ivan Labat ,  Y. Tang ,  Radoje Drmanac ,  Chenghua Liu ,  Juhi Lee ,  Nancy Mize ,  John Childs ,  Cheng-Chi Chao

发明人： Ivan Labat ,  Y. Tang ,  Radoje Drmanac ,  Chenghua Liu ,  Juhi Lee ,  Nancy Mize ,  John Childs ,  Cheng-Chi Chao

IPC分类号： A61K48/00 ,  C07H21/04 ,  C12P21/06 ,  C07K14/475

CPC分类号： C07K14/475 ,  A61K38/00

摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof the correspond to a novel human secreted stem cell growth factor-like polypeptide. These polypeptides comprise nucleic acid sequences isolated from cDNA libraries prepared from human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invertion include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

摘要翻译： 本发明提供了由这样的多核苷酸编码的新型多核苷酸和多肽，其突变体或变体对应于新的人分泌的干细胞生长因子样多肽。 这些多肽包含从人胎肝脾，卵巢，成人脑，肺肿瘤，脊髓，子宫颈，卵巢，内皮细胞，脐带，淋巴细胞，肺成纤维细胞，胎儿脑和睾丸制备的cDNA文库中分离的核酸序列。 逆转的其他方面包括含有产生新的人分泌干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

公开(公告)号：US20080227200A1

公开(公告)日：2008-09-18

申请号：US11986709

申请日：2007-11-26

申请人： Radoje T. Drmanac ,  Ivan Labat ,  Y. Tom Tang ,  Juhi Lee ,  Birgit Stache-Crain ,  Mitsuo Nishikawa

发明人： Radoje T. Drmanac ,  Ivan Labat ,  Y. Tom Tang ,  Juhi Lee ,  Birgit Stache-Crain ,  Mitsuo Nishikawa

IPC分类号： C12N5/06 ,  C12N15/11 ,  C07K14/00 ,  C07K16/18 ,  C12N15/00

CPC分类号： C12N5/0647 ,  A61K38/00 ,  C07K14/475

摘要： A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.

摘要翻译： 通过比较支持造血干细胞或造血祖细胞的增殖或存活的细胞之间的表达基因和不支持增殖的细胞，分离编码具有支持造血干细胞或造血祖细胞增殖或存活的活性的多肽的基因 或生存。 通过使用分离的基因表达的基质细胞或分离的基因的基因产物来支持造血干细胞或造血祖细胞的增殖或存活。

公开(公告)号：US07320880B2

公开(公告)日：2008-01-22

申请号：US10478926

申请日：2002-06-11

申请人： Mitsuo Nishikawa ,  Radoje T. Drmanac ,  Ivan Lobal ,  Y. Tom Tang ,  Juhi Lee ,  Birgit Stache-Crain

发明人： Mitsuo Nishikawa ,  Radoje T. Drmanac ,  Ivan Lobal ,  Y. Tom Tang ,  Juhi Lee ,  Birgit Stache-Crain

IPC分类号： C07H21/04 ,  C07K14/475 ,  C12N5/00 ,  C12N1/00 ,  C12P21/02

CPC分类号： C12N5/0647 ,  A61K38/00 ,  C07K14/475

摘要： A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.

摘要翻译： 通过比较支持不支持增殖或存活的造血干细胞或造血祖细胞的增殖或存活的细胞之间的表达基因，分离编码具有支持造血干细胞或造血祖细胞的增殖或存活活性的多肽的基因 。 通过使用分离的基因表达的基质细胞或分离的基因的基因产物来支持造血干细胞或造血祖细胞的增殖或存活。