-
公开(公告)号:US08053463B2
公开(公告)日:2011-11-08
申请号:US12043069
申请日:2008-03-05
申请人: Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
发明人: Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
IPC分类号: C07D209/04 , C07D401/02 , A61K31/454 , A61K31/404
CPC分类号: C07D401/12 , C07D209/18 , C07D403/12
摘要: Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ, wherein the compounds have the formula: wherein: X2 and X3 are independently CH or N; and one of X1 and X4 is N or CR4 and the other of X1 and X4 is N or CH.
摘要翻译: 描述了对PPARα,PPARδ和PPARγ中的至少一种有活性的化合物,其可用于涉及调节PPARα,PPARδ和PPARγ中的至少一种的治疗和/或预防方法,其中所述化合物具有下式:其中 :X2和X3独立地是CH或N; X1和X4之一是N或CR4,X1和X4中的另一个是N或CH。
-
公开(公告)号:US20080249137A1
公开(公告)日:2008-10-09
申请号:US11517572
申请日:2006-09-06
申请人: Jack Lin , Patrick Womack , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
发明人: Jack Lin , Patrick Womack , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
IPC分类号: A61K31/44 , C07C235/34 , A61K31/165 , A61K31/192 , A61P3/04 , C07C57/58 , C07D213/64
CPC分类号: C07C317/46 , B82Y15/00 , C07C51/08 , C07C51/09 , C07C59/68 , C07C59/72 , C07C59/90 , C07C61/39 , C07C69/734 , C07C235/34 , C07C235/40 , C07C317/44 , C07C323/20 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07D213/64 , C07D231/12 , C07D231/24 , C07D239/54 , C07D261/08 , C07D263/32 , C07D263/46 , C07D277/24 , C07D277/36 , C07D333/32 , C07D333/34 , G01N33/588 , G01N33/6872 , C07C59/52
摘要: Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
摘要翻译: 描述了对PPARα,PPARδ和PPARγ中的至少一种具有活性的化合物,其可用于涉及调节PPARα,PPARδ和PPARγ的至少一种的治疗和/或预防方法。
-
公开(公告)号:US20120015966A1
公开(公告)日:2012-01-19
申请号:US13243703
申请日:2011-09-23
申请人: Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
发明人: Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
IPC分类号: A61K31/506 , C07D401/12 , C07D403/12 , A61K31/405 , A61K31/4439 , A61K31/4155 , A61P3/04 , A61P3/00 , A61P3/06 , A61P3/10 , A61P3/08 , A61P25/00 , A61P13/12 , A61P27/02 , A61P17/02 , A61P13/10 , A61P1/00 , A61P27/12 , A61P9/12 , A61P9/00 , A61P9/04 , A61P9/10 , A61P43/00 , A61P17/00 , A61P37/06 , A61P29/00 , A61P11/06 , A61P11/00 , A61P15/00 , A61P1/18 , A61P1/16 , A61P25/28 , A61P17/06 , A61P25/16 , A61P7/02 , A61P1/04 , A61P13/00 , A61P31/18 , A61P31/14 , A61P31/04 , A61P25/04 , A61P35/00 , C07D209/18
CPC分类号: C07D401/12 , C07D209/18 , C07D403/12
摘要: Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
摘要翻译: 描述了对PPARα,PPARδ和PPARγ中的至少一种具有活性的化合物,其可用于涉及调节PPARα,PPARδ和PPARγ中的至少一种的治疗和/或预防方法。
-
公开(公告)号:US20080255201A1
公开(公告)日:2008-10-16
申请号:US12043069
申请日:2008-03-05
申请人: Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
发明人: Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
IPC分类号: A61K31/454 , A61K31/404 , C07D209/04 , A61P3/04 , C07D401/02
CPC分类号: C07D401/12 , C07D209/18 , C07D403/12
摘要: Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
-
公开(公告)号:US07531568B2
公开(公告)日:2009-05-12
申请号:US11289656
申请日:2005-11-29
申请人: Jack Lin , Dean R. Artis , Prabha N. Ibrahim , Chao Zhang , Rebecca Zuckerman , Ryan Bremer , Shenghua Shi , Byunghun Lee
发明人: Jack Lin , Dean R. Artis , Prabha N. Ibrahim , Chao Zhang , Rebecca Zuckerman , Ryan Bremer , Shenghua Shi , Byunghun Lee
IPC分类号: A61K31/405 , C07D403/02
CPC分类号: C07D209/36 , C07D209/30 , C07D209/40
摘要: Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
摘要翻译: 描述了对PPARα,PPARδ和PPARγ中的至少一种具有活性的化合物,其可用于涉及调节PPARα,PPARδ和PPARγ的至少一种的治疗和/或预防方法。
-
公开(公告)号:US20080234349A1
公开(公告)日:2008-09-25
申请号:US11517010
申请日:2006-09-06
申请人: Jack Lin , Shenghua Shi , Chao Zhang , Rebecca Zuckerman , Dean R. Artis , Prabha N. Ibrahim , Byunghun Lee
发明人: Jack Lin , Shenghua Shi , Chao Zhang , Rebecca Zuckerman , Dean R. Artis , Prabha N. Ibrahim , Byunghun Lee
IPC分类号: A61K31/4155 , C07D409/12 , A61K31/4025 , A61P25/00 , A61P3/04 , C07D409/14
CPC分类号: C07D409/12 , C07D209/08 , C07D409/14
摘要: Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
-
公开(公告)号:US08415469B2
公开(公告)日:2013-04-09
申请号:US12616079
申请日:2009-11-10
申请人: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , Jianming Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
发明人: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , Jianming Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
IPC分类号: C07D413/14 , C07D401/14 , C07D471/04 , C07F7/02
CPC分类号: C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
-
公开(公告)号:US20070072904A1
公开(公告)日:2007-03-29
申请号:US11517573
申请日:2006-09-06
申请人: Jack Lin , Patrick Womack , Byunghun Lee , Shenghua Shi , Chao Zhang , Rebecca Zuckerman , Dean Artis , Prabha Ibrahim , Weiru Wang
发明人: Jack Lin , Patrick Womack , Byunghun Lee , Shenghua Shi , Chao Zhang , Rebecca Zuckerman , Dean Artis , Prabha Ibrahim , Weiru Wang
IPC分类号: A61K31/4709 , A61K31/404 , C07D409/02
CPC分类号: C07D409/14 , C07D209/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D491/04
摘要: Compounds are described that are active on PPARs, including pan-active compounds and compounds selective for any one or any two of PPARα, PPARα and PPARδ. Also described are methods of use of the compounds in treating various diseases.
摘要翻译: 描述了对PPARs有活性的化合物,包括对于PPARα,PPARα和PPARδ的任何一种或任何两种选择性的泛活性化合物和化合物。 还描述了使用这些化合物治疗各种疾病的方法。
-
公开(公告)号:US07605168B2
公开(公告)日:2009-10-20
申请号:US11219635
申请日:2005-09-02
申请人: Prabha N. Ibrahim , Ryan Bremer , Sam Gillette , Hanna Cho , Marika Nespi , Shumeye Mamo , Chao Zhang , Dean R. Artis , Byunghun Lee , Rebecca Zuckerman
发明人: Prabha N. Ibrahim , Ryan Bremer , Sam Gillette , Hanna Cho , Marika Nespi , Shumeye Mamo , Chao Zhang , Dean R. Artis , Byunghun Lee , Rebecca Zuckerman
IPC分类号: A61K31/437 , A61K31/403 , C07D471/02 , C07D405/02
CPC分类号: C07D471/04 , C07D209/12 , C07D401/12 , C07D405/04 , G06F19/16 , G06F19/706
摘要: Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and structural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.
摘要翻译: 描述了在PDE4上有活性的化合物。 还描述了使用X射线晶体学测定的PDE4B的晶体结构,使用PDE4B晶体和用于鉴定分子支架的结构信息,用于开发结合和调节PDE4B的配体,以及基于已知配体鉴定改进的配体。
-
10.
公开(公告)号:US20120053177A1
公开(公告)日:2012-03-01
申请号:US13243748
申请日:2011-09-23
申请人: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
发明人: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
IPC分类号: A61K31/5377 , A61P35/00 , A61K31/496 , A61K31/506 , C12N9/99 , A61K31/437
CPC分类号: C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译: 描述了对蛋白激酶有活性的化合物,以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。
-
-
-
-
-
-
-
-
-