公开(公告)号：US4625995A

公开(公告)日：1986-12-02

申请号：US708528

申请日：1985-03-05

申请人： Jacques Aubry ,  Michel Bonfils ,  Jean-Paul Merlet

发明人： Jacques Aubry ,  Michel Bonfils ,  Jean-Paul Merlet

IPC分类号： B60G3/14 ,  B60G21/05 ,  F16F1/366 ,  B60G11/20

CPC分类号： B60G21/051 ,  F16F1/366 ,  B60G2200/22 ,  B60G2202/1351 ,  B60G2202/1362 ,  B60G2206/16 ,  B60G2206/162

摘要： Suspension for a two-sheeled undercarriage of a vehicle comprising two arms pivotable about an axis transversal to said vehicle, each arm carrying one wheel, and an assembly of tubes of axes parallel to said transversal axis and made of a composite material of fibers and synthetic material.The suspension according to the invention is remarkable in that said assembly comprises a first tube integral with the vehicle chassis by each of its ends, and about which tube each arm can pivot, as well as two second tubes integral by each of their ends with one of said arms, said first tube and said second tubes being interconnected in their middle part.

摘要翻译： 悬架用于车辆的双剪切底盘，包括两个可围绕轴线横向于所述车辆枢转的臂，每个臂承载一个车轮，以及与所述横向轴线平行的轴的组件，由纤维和合成材料的复合材料制成 材料。 根据本发明的悬架是显着的，因为所述组件包括与其车辆底盘的每个端部一体形成的第一管，并且每个臂可枢转的管以及由其每个端部一体形成的两个第二管，一个 所述第一管和所述第二管在其中间部分互连。

公开(公告)号：US4629213A

公开(公告)日：1986-12-16

申请号：US717152

申请日：1985-03-28

申请人： Jacques Aubry ,  Michel Bonfils ,  Jean-Paul Merlet

发明人： Jacques Aubry ,  Michel Bonfils ,  Jean-Paul Merlet

IPC分类号： B60G9/00 ,  B60G11/44 ,  B60G9/04 ,  B62D53/02

CPC分类号： B60G9/00 ,  B60G11/44

摘要： The invention relates to a suspension system for a set of vehicle wheels with rigid axle, said suspension system comprising, on the one hand, a longitudinal torsion tube articulated at one of its ends on the chassis of the vehicle so as to be able to pivot about a transverse horizontal axis without possibility of rotating about its longitudinal axis and fast at its other end with said rigid axle and, on the other hand, two longitudinal elastic blades which are disposed laterally each on one side of said torsion tube and of which each is fixed at one of its ends to said axle, is pivoted in its intermediate part on said chassis about a transverse axis and is in abutment at its other end against said chassis. The invention is more particularly applicable to a suspension for road tractor.

摘要翻译： 本发明涉及一种用于具有刚性轴的车轮组的悬架系统，所述悬架系统一方面包括一个纵向扭力管，该纵向扭力管铰接在车辆底盘的一端，以便能够枢转 围绕横向水平轴线而没有围绕其纵向轴线旋转的可能性，并且在其另一端快速地具有所述刚性轴，另一方面，两个纵向弹性叶片横向设置在所述扭转管的一侧上，并且其中每个 在其一端固定到所述轴，在其横向轴线上在所述底盘上的中间部分枢转，并且在其另一端处抵靠所述底盘。 本发明更特别适用于道路拖拉机的悬架。

公开(公告)号：US4621834A

公开(公告)日：1986-11-11

申请号：US717038

申请日：1985-03-28

申请人： Jacques Aubry ,  Michel Bonfils ,  Jean-Paul Merlet

发明人： Jacques Aubry ,  Michel Bonfils ,  Jean-Paul Merlet

IPC分类号： B60G9/04 ,  B60G11/44 ,  B60G21/055 ,  B62D53/06

CPC分类号： B60G11/44 ,  B60G21/055

摘要： The invention relates to a suspension system for a set of vehicle wheels with rigid axle, wherein it comprises, on the one hand, a horizontal and transverse torsion bar articulated so as to be able to rotate about its longitudinal axis and, on the other hand, two longitudinal elastic blades which are disposed laterally each on one side of said chassis and of which each is rigidly connected at one of its ends to said torsion bar, is fixed in its intermediate part to said rigid axle and is in abutment at its other end against said chassis. The invention is more particularly applicable to a suspension system for road tractor.

摘要翻译： 本发明涉及一种用于具有刚性轴的车轮组的悬挂系统，其中一方面包括铰接的横向和横向扭杆，以便能够围绕其纵向轴线旋转，另一方面 ，两个纵向弹性叶片，其横向设置在所述底盘的一侧上，并且每个在其一端刚性地连接到所述扭杆，在其中间部分固定到所述刚性轴并且在其另一侧邻接 相对于所述底盘结束。 本发明更特别适用于道路拖拉机的悬挂系统。

公开(公告)号：US20140044721A1

公开(公告)日：2014-02-13

申请号：US13983937

申请日：2012-02-07

申请人： François Paris ,  Stephane Birkle ,  Ariane Desselle ,  Jacques Aubry ,  Marie-Hélène Gaugler ,  Denis Cochonneau ,  Tanguy Chaumette

发明人： François Paris ,  Stephane Birkle ,  Ariane Desselle ,  Jacques Aubry ,  Marie-Hélène Gaugler ,  Denis Cochonneau ,  Tanguy Chaumette

IPC分类号： C07K16/28

CPC分类号： C07K16/28 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3084 ,  C07K16/44 ,  C07K2317/73 ,  C07K2317/734 ,  C07K2317/92

摘要： The present invention lies in the field of new cancer therapies, more precisely in the field of antiangiogenic compounds. It notably concerns anti-Gb3 antibodies having specific CDR sequences, as well as the use of anti-Gb3 antibodies not coupled to a therapeutic molecule in the treatment of diseases associated with angiogenesis, such as solid tumors.

摘要翻译： 本发明在于新的癌症治疗领域，更准确地说是抗血管生成化合物领域。 它特别涉及具有特定CDR序列的抗Gb3抗体，以及在治疗与血管发生相关的疾病如固体肿瘤中使用不与治疗分子偶联的抗Gb3抗体。

公开(公告)号：US4768630A

公开(公告)日：1988-09-06

申请号：US946070

申请日：1986-12-24

申请人： Jacques Aubry ,  Michel Deguise

发明人： Jacques Aubry ,  Michel Deguise

IPC分类号： B60G13/08 ,  F16F9/10 ,  F16F9/14 ,  F16F9/52 ,  F16F13/08

CPC分类号： F16F9/52 ,  F16F13/08 ,  F16F9/10 ,  F16F9/145 ,  B60G2202/112 ,  B60G2202/22 ,  B60G2202/24 ,  F16F2230/105

摘要： A rotary damper comprises a stator and a rotor which are co-axial, circular and cylindrical, two extreme faces substantialy transversal to the axis of the stator and rotor and disposed respectively on either side of the stator and rotor, a main chamber filled with a fluid, defined between the extreme faces and the stator and the rotor, blades disposed on the stator and rotor and dividing the main chamber is a plurality of volumes, the blades laminating the flow of fluid through the different volumes of the main chamber, and an auxiliary chamber which communicates with the main chamber. The auxiliary chamber is at least partly formed by a diaphragm which is elastically deformable and which is designed to compensate for the volume variations of the fluid as a function of its temperature, and to bring in, if necessary, a twisting stiffness in parallel to the damping function. The rotary damper finds application for example in vehicle suspensions.

摘要翻译： 旋转阻尼器包括同轴，圆形和圆柱形的定子和转子，两个极面基本上横贯于定子和转子的轴线，分别设置在定子和转子的任一侧上，主室充满 限定在极面与定子和转子之间的流体，设置在定子和转子上并分隔主室的叶片是多个体积，叶片将流体流通过主室的不同体积，并且 辅助室与主室连通。 辅助室至少部分地由隔膜形成，该膜片是可弹性变形的，其被设计成补偿作为其温度的函数的流体的体积变化，并且如果必要的话，将平行于 阻尼功能。 旋转阻尼器可用于例如车辆悬架中。

公开(公告)号：US4706364A

公开(公告)日：1987-11-17

申请号：US822240

申请日：1986-01-24

申请人： Jacques Aubry

发明人： Jacques Aubry

IPC分类号： F16D1/06 ,  B29C65/00 ,  B29C65/56 ,  B29C70/76 ,  B29C70/86 ,  F16B4/00 ,  F16C3/02 ,  F16C7/00 ,  F16L39/00 ,  B32B5/12

CPC分类号： B29C65/00 ,  B29C66/5344 ,  B29C66/71 ,  B29C66/721 ,  B29C70/766 ,  B29C70/86 ,  F16C3/026 ,  B29K2105/06 ,  B29L2031/75 ,  Y10S285/915 ,  Y10T29/49885 ,  Y10T29/49945 ,  Y10T29/49982

摘要： This invention relates to a process for connecting an element to the end of a tube of composite material, wherein, at least at said end, said tube presents an annular cross-section of which the outer and inner contours are each constituted by a circular line or with interference of shapes, for example polygonal, and said element comprises a recess defined between two spaced apart coaxial prismatic or cylindrical walls, the annular section of said recess corresponding to that of said end so that the latter may be fitted in said element with interposition of an intercalated sleeve made of high-resistance fibers impregnated with resin or polymerizable elastomer. The invention is more particularly applicable to the production of torque tubes or power transmission shafts made of composite material.

摘要翻译： 本发明涉及一种用于将元件连接到复合材料管的端部的方法，其中至少在所述端部处，所述管呈现环形横截面，其外轮廓和内轮廓各自由圆形线 或者具有形状的干涉，例如多边形，并且所述元件包括限定在两个间隔开的同轴棱柱形或圆柱形壁之间的凹部，所述凹部的环形部分对应于所述端部的环形部分，使得后者可以装配在所述元件中， 插入由浸渍有树脂或可聚合弹性体的高电阻纤维制成的插层套筒。 本发明更特别适用于由复合材料制成的扭矩管或动力传递轴的生产。

公开(公告)号：US08951524B2

公开(公告)日：2015-02-10

申请号：US12445071

申请日：2007-10-10

申请人： Stéphane Birkle ,  Jean-Marie Mussini ,  Jacques Aubry ,  Jacques Barbet ,  Jean-Francois Chatal

发明人： Stéphane Birkle ,  Jean-Marie Mussini ,  Jacques Aubry ,  Jacques Barbet ,  Jean-Francois Chatal

IPC分类号： C07K16/30 ,  A61K39/00

CPC分类号： C07K16/3084 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565

摘要： The invention relates to the use of monoclonal antibodies that only recognise the O-acetylated form of the GD2 ganglioside, or fragments of said antibody, for the diagnosis and the treatment of cancers in which the cells express the O-acetylated GD2, said antibody or said fragment recognising the O-acetylated GD2 molecules expressed by the tumoral cells and not recognising the GD2 molecules expressed at the surface of the peripheral nerves, in order to increase the specificity of the diagnosis and reduce the toxicity of the treatments. The invention also relates to artificially modified antibodies advantageously used for treating and diagnosing cancers in which the cells express the O-acetylated GD2.

摘要翻译： 本发明涉及仅识别GD2神经节苷脂的O-乙酰化形式或所述抗体的片段的单克隆抗体用于诊断和治疗其中细胞表达O-乙酰化GD2的所述抗体或所述抗体的所述抗体或 所述片段识别由肿瘤细胞表达的O-乙酰化GD2分子，并且不识别在外周神经表面表达的GD2分子，以增加诊断的特异性并降低治疗的毒性。 本发明还涉及有利地用于治疗和诊断细胞表达O-乙酰化GD2的癌症的人造修饰的抗体。

公开(公告)号：US20100150910A1

公开(公告)日：2010-06-17

申请号：US12445071

申请日：2007-10-10

申请人： Stéphane Birkle ,  Jean-Marie Mussini ,  Jacques Aubry ,  Jacques Barbet ,  Jean-Francois Chatal

发明人： Stéphane Birkle ,  Jean-Marie Mussini ,  Jacques Aubry ,  Jacques Barbet ,  Jean-Francois Chatal

IPC分类号： A61K39/395 ,  A61P35/00

CPC分类号： C07K16/3084 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565

摘要： The invention relates to the use of monoclonal antibodies that only recognise the O-acetylated form of the GD2 ganglioside, or fragments of said antibody, for the diagnosis and the treatment of cancers in which the cells express the O-acetylated GD2, said antibody or said fragment recognising the O-acetylated GD2 molecules expressed by the tumoral cells and not recognising the GD2 molecules expressed at the surface of the peripheral nerves, in order to increase the specificity of the diagnosis and reduce the toxicity of the treatments. The invention also relates to artificially modified antibodies advantageously used for treating and diagnosing cancers in which the cells express the O-acetylated GD2.

摘要翻译： 本发明涉及仅识别GD2神经节苷脂的O-乙酰化形式或所述抗体的片段的单克隆抗体用于诊断和治疗其中细胞表达O-乙酰化GD2的所述抗体或所述抗体的所述抗体或 所述片段识别由肿瘤细胞表达的O-乙酰化GD2分子，并且不识别在外周神经表面表达的GD2分子，以增加诊断的特异性并降低治疗的毒性。 本发明还涉及有利地用于治疗和诊断细胞表达O-乙酰化GD2的癌症的人造修饰的抗体。