-
公开(公告)号:US20060122397A1
公开(公告)日:2006-06-08
申请号:US11274611
申请日:2005-11-14
申请人: Jalaj Arora , Louise Edwards , Methvin Isaac , Donald McLeod , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Helena Gyback , Martin Johansson , Annika Kers , John Malmberg , Alexander Minidis , Karin Oscarsson , Mangus Waldman , Ulrika Yngve , Christoffer Osterwall
发明人: Jalaj Arora , Louise Edwards , Methvin Isaac , Donald McLeod , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Helena Gyback , Martin Johansson , Annika Kers , John Malmberg , Alexander Minidis , Karin Oscarsson , Mangus Waldman , Ulrika Yngve , Christoffer Osterwall
IPC分类号: A61K31/4439 , A61K31/4245 , C07D417/14 , C07D413/14 , C07D409/14
CPC分类号: C07D413/14 , C07D413/12 , C07D417/14
摘要: The present invention relates to new compounds of formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译: 本发明涉及新的式I化合物,其制备方法和其中制备的新中间体,含有所述化合物的药物制剂和所述化合物在治疗中的用途。
-
公开(公告)号:US07456200B2
公开(公告)日:2008-11-25
申请号:US11274611
申请日:2005-11-14
申请人: Jalaj Arora , Louise Edwards , Methvin Isaac , Donald A. McLeod , Abdelmalik Slassi , Tomislav Stefanac , Thomas M. Stormann , David Wensbo , Tao Xin , Helena Gyback , Martin Johansson , Annika Kers , John Malmberg , Alexander Minidis , Karin Oscarsson , Mangus Waldman , Ulrika Yngve , Christoffer Osterwall
发明人: Jalaj Arora , Louise Edwards , Methvin Isaac , Donald A. McLeod , Abdelmalik Slassi , Tomislav Stefanac , Thomas M. Stormann , David Wensbo , Tao Xin , Helena Gyback , Martin Johansson , Annika Kers , John Malmberg , Alexander Minidis , Karin Oscarsson , Mangus Waldman , Ulrika Yngve , Christoffer Osterwall
IPC分类号: A61K31/44 , C07D413/14
CPC分类号: C07D413/14 , C07D413/12 , C07D417/14
摘要: The present invention relates to new compounds of formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing compounds of the formula I and to the use of compounds of the formula I in therapy.
摘要翻译: 本发明涉及新的式I化合物,其制备方法和其中制备的新中间体,含有式I化合物的药物制剂和式I化合物在治疗中的用途。
-
3.Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 审中-公开
标题翻译: 额外的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号:US20070179188A1
公开(公告)日:2007-08-02
申请号:US10588702
申请日:2005-02-15
申请人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald Mcleod , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald Mcleod , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号: A61K31/4439 , A61K31/4245 , C07D413/14 , C07D413/02
CPC分类号: C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要: The present invention relates to new compounds of formula (I), to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译: 本发明涉及新的式(I)化合物,含有该化合物的药物制剂,以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
-
公开(公告)号:US20060063772A1
公开(公告)日:2006-03-23
申请号:US11270617
申请日:2005-11-10
申请人: Jalaj Arora , Louise Edwards , Methvin Isaac , Donald McLeod , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Annika Kers , Johan Malmberg , Karin Oscarsson
发明人: Jalaj Arora , Louise Edwards , Methvin Isaac , Donald McLeod , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Annika Kers , Johan Malmberg , Karin Oscarsson
IPC分类号: A61K31/496 , C07D403/14
CPC分类号: C07D271/06 , C07D261/08 , C07D261/14 , C07D271/07 , C07D271/107 , C07D271/113 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/14
摘要: The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, X4, R, R1, R2, R3, R4, R5, R6, R7, m, n, o, p and q are defined as in any one of claims 1 to 12, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译: 本发明涉及新的式I化合物,
-
5.
公开(公告)号:US20080015234A1
公开(公告)日:2008-01-17
申请号:US11840952
申请日:2007-08-18
申请人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号: A61K31/4439 , A61K31/4196 , A61K31/4245 , A61P19/06 , A61P25/18 , A61P25/30 , A61P29/00 , A61P9/00 , C07D413/14 , C12N5/00 , C07D271/06 , A61P35/00 , A61P27/02 , A61P25/28 , A61P25/08 , A61P19/02 , A61K31/443
CPC分类号: C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
-
6.Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 失效
标题翻译: 额外的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号:US20050272779A1
公开(公告)日:2005-12-08
申请号:US11053752
申请日:2005-02-09
申请人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号: A61K31/4245 , A61K31/4439 , C07D413/14
CPC分类号: C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译: 本发明涉及新的式I化合物,含有该化合物的药物制剂,以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
-
7.ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS 审中-公开
标题翻译: 其他杂环化合物及其作为代谢谷氨酸受体拮抗剂的使用公开(公告)号:US20080045571A1
公开(公告)日:2008-02-21
申请号:US11840953
申请日:2007-08-18
申请人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号: A61K31/4439 , A61K31/4196 , A61K31/4245 , A61P19/06 , A61P25/18 , A61P25/30 , A61P29/00 , A61P9/00 , C07D413/14 , C12N5/00 , C07D271/06 , A61P35/00 , A61P27/02 , A61P25/28 , A61P25/08 , A61P19/02 , A61K31/443
CPC分类号: C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译: 本发明涉及新的式I化合物,含有该化合物的药物制剂,以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
-
8.
公开(公告)号:US20080015204A1
公开(公告)日:2008-01-17
申请号:US11840955
申请日:2007-08-18
申请人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号: A61K31/519 , A61K31/4196 , A61K31/4245 , A61P19/02 , A61P25/08 , A61P25/28 , A61P27/02 , A61P35/00 , C07D271/06 , C07D487/04 , C07D413/14 , A61P9/00 , A61P29/00 , A61P25/30 , A61P25/18 , A61P19/06 , A61K31/443 , A61K31/4439
CPC分类号: C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
-
9.ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS 审中-公开
标题翻译: 其他杂环化合物及其作为代谢谷氨酸受体拮抗剂的使用公开(公告)号:US20070293545A1
公开(公告)日:2007-12-20
申请号:US11840954
申请日:2007-08-18
申请人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号: A61K31/41 , A61K31/44 , A61P25/00 , C07D413/02 , C12N5/00
CPC分类号: C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译: 本发明涉及新的式I化合物,含有该化合物的药物制剂,以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
-
10.Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 失效
标题翻译: 额外的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号:US07585881B2
公开(公告)日:2009-09-08
申请号:US11053752
申请日:2005-02-09
申请人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tau Xin , Jalaj Arora
发明人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tau Xin , Jalaj Arora
IPC分类号: A61K31/4439 , C07D401/14 , C07D413/04
CPC分类号: C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译: 本发明涉及新的式I化合物,含有该化合物的药物制剂,以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
-
-
-
-
-
-
-
-
-