-
1.BENZIMIDAZOLE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS 失效
标题翻译: 用于治疗或预防感染病毒的苯唑咪唑类似物公开(公告)号:US20110172238A1
公开(公告)日:2011-07-14
申请号:US12838350
申请日:2010-07-16
申请人: James A. Henderson , John Maxwell , Louis Vaillancourt , Mark Morris , Ronald Grey, JR. , Simon Giroux , Laval Chan Chun Kong , Sanjoy Kumar Das , Bingcan Liu , Carl Poisson , Caroline Cadilhac , Monica Bubenik , T. Jagadeeswar Reddy , Guy Falardeau , Constantin Yannopoulos , Jian Wang , Oswy Z. Pereira , Youssef L. Bennani , Albert C. Pierce , Govinda Rao Bhisetti , Kevin M. Cottrell , Valerie Marone
发明人: James A. Henderson , John Maxwell , Louis Vaillancourt , Mark Morris , Ronald Grey, JR. , Simon Giroux , Laval Chan Chun Kong , Sanjoy Kumar Das , Bingcan Liu , Carl Poisson , Caroline Cadilhac , Monica Bubenik , T. Jagadeeswar Reddy , Guy Falardeau , Constantin Yannopoulos , Jian Wang , Oswy Z. Pereira , Youssef L. Bennani , Albert C. Pierce , Govinda Rao Bhisetti , Kevin M. Cottrell , Valerie Marone
IPC分类号: A61K31/496 , C07D403/14 , A61K31/4184 , C07D401/14 , A61K31/4545 , A61K31/506 , A61K31/4439 , A61P31/14
CPC分类号: C07K5/06052 , C07D401/14 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D495/04
摘要: Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B′, X, Y, R1, R1′, R2, R2′, R3, R3′, R5, R5′, R6, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.
摘要翻译: 其中A,B,B',X,Y,R1,R1',R2,R2',R3,R3',R5,R5',R6,m, n或p如本文所定义,可用于治疗黄病毒科病毒感染。
-
2.Benzimidazole analogues for the treatment or prevention of flavivirus infections 失效
标题翻译: 苯并咪唑类似物用于治疗或预防黄病毒感染公开(公告)号:US08354419B2
公开(公告)日:2013-01-15
申请号:US12838350
申请日:2010-07-16
申请人: James A. Henderson , John Maxwell , Louis Vaillancourt , Mark Morris , Ronald Grey, Jr. , Simon Giroux , Laval Chan Chun Kong , Sanjoy Kumar Das , Bingcan Liu , Carl Poisson , Caroline Cadilhac , Monica Bubenik , T. Jagadeeswar Reddy , Guy Falardeau , Constantin Yannopoulos , Jian Wang , Oswy Z. Pereira , Youssef L. Bennani , Albert C. Pierce , Govinda Rao Bhisetti , Kevin M. Cottrell , Valerie Marone
发明人: James A. Henderson , John Maxwell , Louis Vaillancourt , Mark Morris , Ronald Grey, Jr. , Simon Giroux , Laval Chan Chun Kong , Sanjoy Kumar Das , Bingcan Liu , Carl Poisson , Caroline Cadilhac , Monica Bubenik , T. Jagadeeswar Reddy , Guy Falardeau , Constantin Yannopoulos , Jian Wang , Oswy Z. Pereira , Youssef L. Bennani , Albert C. Pierce , Govinda Rao Bhisetti , Kevin M. Cottrell , Valerie Marone
IPC分类号: A61K31/506 , A61K31/4439 , A61K31/4184 , C07D403/14 , C07D401/14
CPC分类号: C07K5/06052 , C07D401/14 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D495/04
摘要: Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B′, X, Y, R1, R1′, R2, R2′, R3, R3′, R5, R5′, R6, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.
摘要翻译: 由式I表示的化合物或其药学上可接受的盐和溶剂化物,其中A,B,B',X,Y,R1,R1',R2,R2',R3,R3',R5,R5',R6, n或p如本文所定义,可用于治疗黄病毒科病毒感染。
-
公开(公告)号:US07598245B2
公开(公告)日:2009-10-06
申请号:US11787165
申请日:2007-04-13
申请人: Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey, Jr. , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco G. Salituro , Jian Wang
发明人: Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey, Jr. , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco G. Salituro , Jian Wang
IPC分类号: A61K31/427 , A61K31/5377 , C07D413/12 , C07D263/32 , C07D249/08
CPC分类号: C07D401/04 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物,制备化合物的方法和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US07902239B2
公开(公告)日:2011-03-08
申请号:US11774702
申请日:2007-07-09
申请人: Albert C. Pierce , Michael Arnost , Robert J. Davies , Cornelia J. Forster , Vincent Galullo , Ronald Grey, Jr. , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco G. Salituro , Jian Wang
发明人: Albert C. Pierce , Michael Arnost , Robert J. Davies , Cornelia J. Forster , Vincent Galullo , Ronald Grey, Jr. , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco G. Salituro , Jian Wang
IPC分类号: A61K31/541 , A61K31/55 , A61K31/4196 , A61K31/5377
CPC分类号: C07D401/04 , C07D249/10 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07D495/04
摘要: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US07226920B2
公开(公告)日:2007-06-05
申请号:US10914051
申请日:2004-08-06
申请人: Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey, Jr. , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco G. Salituro , Jian Wang
发明人: Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey, Jr. , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco G. Salituro , Jian Wang
IPC分类号: A61K31/427 , A61K31/5377 , C07D413/12 , C07D263/32 , C07D249/08
CPC分类号: C07D401/04 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物,制备化合物的方法和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US07279469B2
公开(公告)日:2007-10-09
申请号:US10715111
申请日:2003-11-17
申请人: Albert C. Pierce , Michael Amost , Robert J. Davies , Cornelia J. Forster , Vincent Galullo , Ronald Grey, Jr. , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco G. Salituro , Jian Wang
发明人: Albert C. Pierce , Michael Amost , Robert J. Davies , Cornelia J. Forster , Vincent Galullo , Ronald Grey, Jr. , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco G. Salituro , Jian Wang
IPC分类号: A61K31/541 , A61K31/55 , A61K31/4196 , A61K31/5377 , C07D417/02 , C07D413/02
CPC分类号: C07D401/04 , C07D249/10 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07D495/04
摘要: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US20050261268A1
公开(公告)日:2005-11-24
申请号:US10914051
申请日:2004-08-06
申请人: Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco Salituro , Jian Wang
发明人: Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco Salituro , Jian Wang
IPC分类号: A61P35/00 , C07D249/14 , C07D401/04 , C07D401/14 , C07D403/04 , A61K31/545 , A61K31/4196 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , C07D501/14 , C07D43/02
CPC分类号: C07D401/04 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物,制备化合物的方法和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US20120040950A1
公开(公告)日:2012-02-16
申请号:US12974388
申请日:2010-12-21
申请人: Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, JR. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
发明人: Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, JR. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
IPC分类号: A61K31/4439 , C07D401/14 , A61K31/444 , C07D471/04 , A61K31/437 , C07D403/14 , A61K31/506 , C07D413/14 , A61K31/5377 , A61P37/00 , A61P29/00 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , A61P25/14 , C12N9/99 , C07D401/10
CPC分类号: C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20
摘要: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
-
公开(公告)号:US20120202784A1
公开(公告)日:2012-08-09
申请号:US13349868
申请日:2012-01-13
申请人: Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, JR. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
发明人: Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, JR. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
IPC分类号: A61K31/437 , A61K31/5377 , C12N9/99 , A61K31/496 , A61K31/551 , C07D471/20 , C07D471/04 , C07D491/20
CPC分类号: C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20
摘要: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作PI3K抑制剂,特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。
-
公开(公告)号:US08466288B2
公开(公告)日:2013-06-18
申请号:US13349868
申请日:2012-01-13
申请人: Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, Jr. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
发明人: Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, Jr. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
IPC分类号: C07D471/02 , C07D213/04 , C07D401/00 , C07D401/02 , C12N9/99 , A61K31/437
CPC分类号: C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20
摘要: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作PI3K抑制剂,特别是PI3Kgamma的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。
-
-
-
-
-
-
-
-
-