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公开(公告)号:US20120232068A1
公开(公告)日:2012-09-13
申请号:US13393328
申请日:2010-09-01
申请人: James A. Johnson , John Lloyd , Heather Finlay , Ji Jiang , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee
发明人: James A. Johnson , John Lloyd , Heather Finlay , Ji Jiang , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee
IPC分类号: A61K31/517 , C07D413/12 , A61P9/06 , C07D513/04 , A61K31/549 , C07D401/14 , A61K31/5377
CPC分类号: C07D401/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要: A compound of formula (I) wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur associated disorders, and other disorders mediated by ion channel function.
摘要翻译: 其中A,X,Y,Z,R 1和R 24的式(I)化合物在本文中描述。 该化合物可用作钾通道功能的抑制剂和用于治疗和预防心律失常,IKur相关疾病以及由离子通道功能介导的其它病症。
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公开(公告)号:US08575184B2
公开(公告)日:2013-11-05
申请号:US13393328
申请日:2010-09-01
申请人: James A. Johnson , John Lloyd , Heather Finlay , Ji Jiang , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee
发明人: James A. Johnson , John Lloyd , Heather Finlay , Ji Jiang , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee
IPC分类号: A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号: C07D401/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要: A compound of formula (I) wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
摘要翻译: 其中A,X,Y,Z,R 1和R 24的式(I)化合物在本文中描述。 这些化合物可用作钾通道功能的抑制剂和治疗和预防心律失常,IKur相关疾病以及由离子通道功能介导的其它病症。
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