-
公开(公告)号:US07989432B2
公开(公告)日:2011-08-02
申请号:US12142608
申请日:2008-06-19
IPC分类号: A61K31/70
CPC分类号: A61K31/7024 , A61K9/107 , A61K9/1075 , A61K9/19 , A61K31/665 , A61K31/70
摘要: The present invention provides micelles, solutions comprising micelles, methods for preparing micelles, and methods for delivering micelles to patients. The micelles have fixed, preselected hydrodynamic diameters and are formed from basic or acidic amphiphilic compounds.
摘要翻译: 本发明提供胶束,包含胶束的溶液,制备胶束的方法以及将胶束递送给患者的方法。 胶束具有固定的,预选的流体动力学直径,并由碱性或酸性两亲性化合物形成。
-
公开(公告)号:US07390793B2
公开(公告)日:2008-06-24
申请号:US11106654
申请日:2005-04-15
IPC分类号: A61K31/70
CPC分类号: A61K31/7024 , A61K9/107 , A61K9/1075 , A61K9/19 , A61K31/665 , A61K31/70
摘要: The present invention provides micelles, solutions comprising micelles, methods for preparing micelles, and methods for delivering micelles to patients. The micelles have fixed, preselected hydrodynamic diameters and are formed from basic or acidic amphiphilic compounds.
摘要翻译: 本发明提供胶束,包含胶束的溶液,制备胶束的方法以及将胶束递送给患者的方法。 胶束具有固定的,预选的流体动力学直径,并由碱性或酸性两亲性化合物形成。
-
公开(公告)号:US20090136564A1
公开(公告)日:2009-05-28
申请号:US12142608
申请日:2008-06-19
IPC分类号: A61K9/127 , A61K31/351 , A61P43/00
CPC分类号: A61K31/7024 , A61K9/107 , A61K9/1075 , A61K9/19 , A61K31/665 , A61K31/70
摘要: The present invention provides micelles, solutions comprising micelles, methods for preparing micelles, and methods for delivering micelles to patients. The micelles have fixed, preselected hydrodynamic diameters and are formed from basic or acidic amphiphilic compounds.
摘要翻译: 本发明提供胶束,包含胶束的溶液,制备胶束的方法以及将胶束递送给患者的方法。 胶束具有固定的,预选的流体动力学直径,并由碱性或酸性两亲性化合物形成。
-
公开(公告)号:US20050181039A1
公开(公告)日:2005-08-18
申请号:US11106654
申请日:2005-04-15
IPC分类号: A61K9/10 , A61K9/107 , A61K9/19 , A61K31/665 , A61K31/70 , A61K31/7028 , A61K47/04 , A61K47/12 , A61K47/18 , A61P31/04 , A61K9/127 , A61K31/739
CPC分类号: A61K31/7024 , A61K9/107 , A61K9/1075 , A61K9/19 , A61K31/665 , A61K31/70
摘要: The present invention provides micelles, solutions comprising micelles, methods for preparing micelles, and methods for delivering micelles to patients. The micelles have fixed, preselected hydrodynamic diameters and are formed from basic or acidic amphiphilic compounds.
摘要翻译: 本发明提供胶束,包含胶束的溶液,制备胶束的方法以及将胶束递送给患者的方法。 胶束具有固定的,预选的流体动力学直径,并由碱性或酸性两亲性化合物形成。
-
公开(公告)号:US06906042B2
公开(公告)日:2005-06-14
申请号:US10204227
申请日:2001-02-20
IPC分类号: A61K9/10 , A61K9/107 , A61K9/19 , A61K31/665 , A61K31/70 , A61K31/7028 , A61K47/04 , A61K47/12 , A61K47/18 , A61P31/04 , C07H5/00
CPC分类号: A61K31/7024 , A61K9/107 , A61K9/1075 , A61K9/19 , A61K31/665 , A61K31/70
摘要: The invention provides micelles, pharmaceutical formulations comprising micells, solutions comprising micells, methods for preparing micells, methods for delivering micells to patients, and methods for treating sepsis, endotoxemia, septic shock and systemic inflamatory response syndrome in patients by adiministering micelles. The micelles comprises compounds of Forumala (A): wherein the substituents are as defined herein.
摘要翻译: 本发明提供胶束,包含胶束的药物制剂,包含胶束的溶液,制备胶束的方法,将胶束递送给患者的方法,以及通过吸附胶束来治疗患者的败血症,内毒素血症,败血症休克和全身性炎症反应综合征的方法。 胶束包含Forumala(A)的化合物:其中取代基如本文所定义。
-
公开(公告)号:US06828155B1
公开(公告)日:2004-12-07
申请号:US09786060
申请日:2001-03-01
申请人: Kazuhiro Kaneko , Tomohiro Watanabe , Yasuyuki Asai , Yoshihisa Sano , Kiyomi Kikuchi , Ikuo Kushida , Kazuhide Ashizawa
发明人: Kazuhiro Kaneko , Tomohiro Watanabe , Yasuyuki Asai , Yoshihisa Sano , Kiyomi Kikuchi , Ikuo Kushida , Kazuhide Ashizawa
IPC分类号: G01N3300
CPC分类号: A61K9/0019 , A61K31/739 , G01N21/19 , G01N21/6445 , G01N33/92
摘要: The present invention provides an evaluation method and preparation process of injection containing a lipid A analog. Specifically, it provides, in an injection preparation containing a lipid A analog or a pharmacologically acceptable salt thereof, forecasting and evaluating methods of the pharmacokinetics of the lipid A analog, and quality evaluating method and preparation process of the injection, which each comprises measuring membrane fluidity and/or circular dichroism.
摘要翻译: 本发明提供含有脂质A类似物的注射液的评价方法和制备方法。 具体而言,在含有脂质A类似物或其药理学上可接受的盐的注射制剂中,提供了脂质A类似物的药代动力学的预测和评估方法以及注射的质量评估方法和制备方法,每种方法包括测量膜 流动性和/或圆二色性。
-
公开(公告)号:US08383743B2
公开(公告)日:2013-02-26
申请号:US11910216
申请日:2006-03-30
IPC分类号: C08F22/40
CPC分类号: C09D11/30 , B41M5/0047 , C09D11/107 , Y10T428/24851
摘要: Disclosed is an ink composition for jet printer, comprising a pigment, a film forming resin and an organic solvent, the film forming resin being an acrylic copolymer containing, as a monomer unit, at least one of compounds represented by the general formulas (1) and (2): wherein R1 represents a hydrogen atom or a methyl group; R2 represents an alkylene group having 2 to 12 carbon atoms which may be linear or branched; and R3 and R4 each independently represents a hydrogen atom, an alkyl group, an alkenyl group or an aryl group, and the sum of the number of carbon atoms of R3 and R4 is from 4 to 12, or R3 and R4 form a saturated or unsaturated hydrocarbon group which is a five-membered ring formed by combination of the R3 and R4; and wherein R1 represents a hydrogen atom or a methyl group; R2 represents an alkylene group having 2 to 12 carbon atoms which may be linear or branched; and X represents a group selected from the group consisting of groups represented by the general formulas (3) to (9).
摘要翻译: 公开了一种用于喷墨打印机的油墨组合物,其包含颜料,成膜树脂和有机溶剂,所述成膜树脂是含有由通式(1)表示的至少一种化合物作为单体单元的丙烯酸共聚物, 和(2):其中R1表示氢原子或甲基; R 2表示可以是直链或支链的碳原子数为2〜12的亚烷基; 并且R 3和R 4各自独立地表示氢原子,烷基,烯基或芳基,R 3和R 4的碳原子数之和为4至12,或者R 3和R 4形成饱和或 不饱和烃基,其是通过R3和R4的组合形成的五元环; 并且其中R1表示氢原子或甲基; R 2表示可以是直链或支链的碳原子数为2〜12的亚烷基; X表示选自由通式(3)〜(9)表示的基团的基团。
-
公开(公告)号:US06575054B2
公开(公告)日:2003-06-10
申请号:US09819889
申请日:2001-03-29
申请人: Toshiyuki Sugiyama , Kazuhiro Kaneko , Mikio Ochiai , Kazuyoshi Nishijima , Kevin Dominic Delaney
发明人: Toshiyuki Sugiyama , Kazuhiro Kaneko , Mikio Ochiai , Kazuyoshi Nishijima , Kevin Dominic Delaney
IPC分类号: B62D104
CPC分类号: B62D1/04 , Y10T74/20834
摘要: A core bar for a steering wheel includes an upper shell and a lower shell coupled to the upper shell. Each half shell includes a boss core-bar portion coupled to a steering shaft, a rim core-bar portion, and a spoke core-bar portion interposed between the two. An insertion is received in a hollow defined by the upper and lower shells.
摘要翻译: 用于方向盘的芯杆包括上壳体和联接到上壳体的下壳体。 每个半壳包括联接到转向轴的凸台芯棒部分,边缘芯棒部分和插入在两者之间的辐条芯棒部分。 插入件被容纳在由上壳体和下壳体限定的中空部分中。
-
公开(公告)号:US06362720B1
公开(公告)日:2002-03-26
申请号:US09023683
申请日:1998-02-13
申请人: Kazuhiro Kaneko , Kazutaka Nakamura
发明人: Kazuhiro Kaneko , Kazutaka Nakamura
IPC分类号: H01C710
CPC分类号: H01C7/112 , C04B35/453
摘要: There is provided a varistor having high surge resisting capability in spite of its small size and a method of manufacturing the same. The varistor is mainly composed of zinc oxide and contains a composite oxide expressed by the chemical formula Zn2SnO4. It is manufactured using a method wherein zinc oxide and tin oxide are mixed; the mixture is subjected to a thermal process thereafter to obtain a composite oxide expressed by the chemical formula Zn2SnO4; and the composite oxide is combined with the zinc oxide which is the main component and a thermal process is performed to obtain a raw material for the varistor.
-
10.
公开(公告)号:US06224100B1
公开(公告)日:2001-05-01
申请号:US08913914
申请日:1998-03-20
申请人: Yoshifumi Kamano , Kazuyoshi Nishijima , Kazuhiro Kaneko , Naoki Yamamoto , Naoki Horikawa , Keiji Mochizuki
发明人: Yoshifumi Kamano , Kazuyoshi Nishijima , Kazuhiro Kaneko , Naoki Yamamoto , Naoki Horikawa , Keiji Mochizuki
IPC分类号: B60R2120
CPC分类号: B60R21/237 , B60R21/21658 , B60R21/217 , B60R2021/2375
摘要: A pouch-shaped air bag (12) is spread out in a circle. Then, the portion of the air bag (12) located outside the inflator (16) is folded into a wave-like pattern from four directions so that four side portions (61) are formed along the inflator (16). Next, each one of the four excess portions (62), which are continuously formed between each two adjacent side portions (61) and protrude outward, is placed along the outer face of each side portion (61). Thus, the air bag (12) can be easily folded compactly that can be smoothly unfolded.
摘要翻译: 袋形气囊(12)以圆形展开。 然后,位于充气机(16)外侧的气囊(12)的部分从四个方向折叠成波形图案,使得沿着充气机(16)形成四个侧部(61)。 接下来,沿着每个侧部(61)的外表面放置连续形成在两个相邻侧部(61)之间并向外突出的四个多余部分(62)中的每一个。 因此,安全气囊(12)可以容易地折叠成平滑地展开。
-
-
-
-
-
-
-
-
-