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公开(公告)号：US08980876B2
公开(公告)日：2015-03-17
申请号：US13283894
申请日：2011-10-28
IPC分类号： A01N55/02 , C07D213/89
CPC分类号： A01N37/02 , A01N37/10 , A01N37/18 , A01N37/36 , A01N43/40 , A01N43/54 , A01N59/00 , A61K8/27 , A61K8/44 , A61K8/4926 , A61K8/4933 , A61K31/555 , A61K33/30 , A61K38/482 , A61Q5/006 , C12N9/88 , C12Q1/18 , C12Q1/527 , C12Y304/21053 , C12Y402/01003 , A01N59/16
摘要： The present invention is directed to a method of inhibiting aconitase activity of fungal cells in an individual, the method comprising administering an inhibitor of aconitase activity to the fungal cell in an amount effective to inhibit activity of aconitase by said fungal cells.
摘要翻译： 本发明涉及一种抑制个体中真菌细胞的乌头酸酶活性的方法，所述方法包括以有效抑制所述真菌细胞的乌头酸酶活性的量向真菌细胞施用乌头酸酶活性抑制剂。
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2.发明申请公开(公告)号：US20130109664A1
公开(公告)日：2013-05-02
申请号：US13283890
申请日：2011-10-28
申请人： James Robert SCHWARTZ , Charles Winston Saunders , Robert Scott Youngquist , Casey Patrick Kelly , Jeffrey Kenneth Domsic , Robie Lynn Lucas , Jun Xu
发明人： James Robert SCHWARTZ , Charles Winston Saunders , Robert Scott Youngquist , Casey Patrick Kelly , Jeffrey Kenneth Domsic , Robie Lynn Lucas , Jun Xu
IPC分类号： A61K31/555 , A61P17/00
CPC分类号： A61K31/555
摘要： The present invention is directed to a personal care composition comprising an effective amount of a pyrithione or a polyvalent metal salt of a pyrithione; an effective amount of an iron chelator or a material which chelates iron; wherein the combination of the iron chelator and the pyrithione or a polyvalent metal salt of a pyrithione has a fractional inhibitor concentration of less than or equal to 1.
摘要翻译： 本发明涉及一种个人护理组合物，其包含有效量的吡啶硫酮或吡啶硫酮的多价金属盐; 有效量的铁螯合剂或螯合铁的材料; 其中所述铁螯合剂和所述吡啶硫酮或吡啶硫酮的多价金属盐的组合具有小于或等于1的分数抑制剂浓度。
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公开(公告)号：US20130108610A1
公开(公告)日：2013-05-02
申请号：US13283894
申请日：2011-10-28
IPC分类号： A61K38/48 , A61K33/00 , A61K33/40 , A61K31/513 , C12Q1/18 , A01N37/02 , A01N59/00 , A01N37/08 , A01N37/10 , A01N43/54 , A01N37/18 , C07C55/32 , C07C61/06 , C07C63/307 , C12N9/64 , C07D239/60 , A61P31/10 , A01P3/00 , A61P17/00 , C01B21/20 , C01B21/24 , C01B15/01 , C01B15/04 , A61K31/194
CPC分类号： A01N37/02 , A01N37/10 , A01N37/18 , A01N37/36 , A01N43/40 , A01N43/54 , A01N59/00 , A61K8/27 , A61K8/44 , A61K8/4926 , A61K8/4933 , A61K31/555 , A61K33/30 , A61K38/482 , A61Q5/006 , C12N9/88 , C12Q1/18 , C12Q1/527 , C12Y304/21053 , C12Y402/01003 , A01N59/16
摘要： The present invention is directed to a method of inhibiting aconitase activity of fungal cells in an individual, the method comprising administering an inhibitor of aconitase activity to the fungal cell in an amount effective to inhibit activity of aconitase by said fungal cells.
摘要翻译： 本发明涉及一种抑制个体中真菌细胞的乌头酸酶活性的方法，所述方法包括以有效抑制所述真菌细胞的乌头酸酶活性的量向真菌细胞施用乌头酸酶活性抑制剂。
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4.发明授权Intermediates and surfactants useful in household cleaning and personal care compositions, and methods of making the same 有权用于家庭清洁和个人护理组合物的中间体和表面活性剂及其制备方法公开(公告)号：US08933131B2
公开(公告)日：2015-01-13
申请号：US13004072
申请日：2011-01-11
申请人： Thomas Walter Federle , Jeffrey John Scheibel , Zaiyou Liu , Phillip Kyle Vinson , Howard David Hutton, III , John David Carter , Charles Winston Saunders , Jun Xu , Phillip Richard Green
发明人： Thomas Walter Federle , Jeffrey John Scheibel , Zaiyou Liu , Phillip Kyle Vinson , Howard David Hutton, III , John David Carter , Charles Winston Saunders , Jun Xu , Phillip Richard Green
IPC分类号： A61K31/045 , A61K31/255 , C12P7/64 , C12N9/90 , C12N9/00
CPC分类号： C12P7/6409 , C12N9/90 , C12N9/93 , C12Y504/99002 , C12Y604/01003
摘要： Disclosed herein are novel mixtures of scattered-branched chain fatty acids and derivatives of scattered-branched chain fatty acids. Further disclosed are uses of these mixtures in cleaning compositions (e.g., dishcare, laundry, hard surface cleaners) and/or personal care compositions (e.g., skin cleansers, shampoo, hair conditioners).
摘要翻译： 本文公开了分散支链脂肪酸和分散支链脂肪酸衍生物的新型混合物。 还公开了这些混合物在清洁组合物（例如，保健，洗衣，硬表面清洁剂）和/或个人护理组合物（例如，皮肤清洁剂，洗发剂，护发素）中的用途。
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公开(公告)号：US20120014900A1
公开(公告)日：2012-01-19
申请号：US13182943
申请日：2011-07-14
申请人： John David Carter , Elaine Marie Burt , Jeffrey John Scheibel , David Johnathan Kitko , Jun Xu , Charles Winston Saunders , Kenneth Nathan Price , Stephanie Ann Urbin , Phillip Richard Green
发明人： John David Carter , Elaine Marie Burt , Jeffrey John Scheibel , David Johnathan Kitko , Jun Xu , Charles Winston Saunders , Kenneth Nathan Price , Stephanie Ann Urbin , Phillip Richard Green
IPC分类号： A61K8/92 , A61K8/72 , A61Q5/12 , A61K8/898 , A61Q5/00 , A61K8/84 , A61K8/73 , A61K8/88 , A61Q5/02 , A61K8/89 , A61K8/892
摘要： A personal care composition comprising: a near-terminal branched compound according to Formula I; a cosmetically acceptable aqueous carrier; wherein the near-terminal branched compound is not comprised in a gel network.
摘要翻译： 一种个人护理组合物，其包含：根据式I的近端支链化合物; 美容上可接受的水性载体; 其中所述近端支链化合物不包含在凝胶网络中。
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公开(公告)号：US20110166370A1
公开(公告)日：2011-07-07
申请号：US13004077
申请日：2011-01-11
申请人： Charles Winston Saunders , Jun Xu , Leo Timothy Laughlin, II , Zubin Sarosh Khambatta , Phillip Richard Green
发明人： Charles Winston Saunders , Jun Xu , Leo Timothy Laughlin, II , Zubin Sarosh Khambatta , Phillip Richard Green
IPC分类号： C07C53/126 , C12P7/64 , C12N1/00 , C12N1/21
CPC分类号： C12P7/6409 , C12N9/90 , C12N9/93 , C12Y504/99002 , C12Y604/01003
摘要： Methods and cells for producing scattered branched-chain fatty acids are provided. For example, the invention provides a method for producing branched-chain fatty acid comprising a methyl on one or more even number carbons. The method comprises culturing a cell comprising an exogenous or overexpressed polynucleotide comprising a nucleic acid sequence encoding a polypeptide that catalyzes the conversion of propionyl-CoA to methylmalonyl-CoA and/or an exogenous or overexpressed polynucleotide comprising a nucleic acid sequence encoding a polypeptide that catalyzes the conversion of succinyl-CoA to methylmalonyl-CoA, under conditions allowing expression of the polynucleotide(s) and production of branched-chain fatty acid. The cell produces more branched-chain fatty acid comprising a methyl on one or more even number carbons than an otherwise similar cell that does not comprise the polynucleotide(s). A cell that produces branched-chain fatty acid and the branched-chain fatty acid also are provided.
摘要翻译： 提供了生产分散的支链脂肪酸的方法和细胞。 例如，本发明提供一种生产包含一个或多个偶数碳上的甲基的支链脂肪酸的方法。 该方法包括培养包含外源或过表达多核苷酸的细胞，其包含编码催化丙酰CoA转化为甲基丙二酰辅酶A的多肽的核酸序列，和/或外源或过表达的多核苷酸，其包含编码催化的多肽的核酸序列 在允许表达多核苷酸和产生支链脂肪酸的条件下将琥珀酰-CoA转化为甲基丙二酰辅酶A。 与不包含多核苷酸的另外相似的细胞相比，该细胞产生更多的支链脂肪酸，其包含一个或多个偶数碳上的甲基。 还提供了产生支链脂肪酸和支链脂肪酸的细胞。
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公开(公告)号：US08765651B2
公开(公告)日：2014-07-01
申请号：US13182919
申请日：2011-07-14
申请人： Howard David Hutton, III , Jeffrey John Scheibel , David Johnathan Kitko , Jun Xu , Charles Winston Saunders , Kenneth Nathan Price , Stephanie Ann Urbin , Phillip Richard Green
发明人： Howard David Hutton, III , Jeffrey John Scheibel , David Johnathan Kitko , Jun Xu , Charles Winston Saunders , Kenneth Nathan Price , Stephanie Ann Urbin , Phillip Richard Green
摘要： Method of cleansing hair comprising: (a) applying a composition to the hair; (b) dissolving and lathering the composition using a water-based solvent; (c) rinsing the hair with a water-based solvent; wherein during the rinsing a total of about 100 gram to about 300 gram of water-based solvent per gram of hair (dry weight) is employed; wherein the composition comprises from about 3 wt % to about 35 wt % of a mixture of at least two compounds of Formula I.
摘要翻译： 包括：（a）将组合物施用到头发上; （b）使用水基溶剂溶解和起泡该组合物; （c）用水性溶剂漂洗毛发; 其中在漂洗期间使用总共约100g至约300g水基溶剂/克头发（干重）; 其中所述组合物包含约3重量％至约35重量％的至少两种式I化合物的混合物。
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8.发明授权公开(公告)号：US08603449B2
公开(公告)日：2013-12-10
申请号：US13183029
申请日：2011-07-14
申请人： Jorge Max Sunkel , Toshiyuki Iwata , Jeffrey John Scheibel , David Johnathan Kitko , Jun Xu , Charles Winston Saunders , Kenneth Nathan Price , Stephanie Ann Urbin , Phillip Richard Green
发明人： Jorge Max Sunkel , Toshiyuki Iwata , Jeffrey John Scheibel , David Johnathan Kitko , Jun Xu , Charles Winston Saunders , Kenneth Nathan Price , Stephanie Ann Urbin , Phillip Richard Green
摘要： A rinse-off conditioning composition comprising: (a) near-terminal branched alcohol according to Formula I; (b) a cationic surfactant; (c) a terminal aminosilicone; wherein the near-terminal branched alcohol and the cationic surfactant are comprised in a lamellar gel matrix.
摘要翻译： 洗涤调理组合物，其包含：（a）根据式I的近端支链醇; （b）阳离子表面活性剂; （c）末端氨基硅氧烷; 其中所述近末端支链醇和阳离子表面活性剂包含在层状凝胶基质中。
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9.发明申请公开(公告)号：US20120014901A1
公开(公告)日：2012-01-19
申请号：US13183029
申请日：2011-07-14
申请人： Jorge Max Sunkel , Toshiyuki Iwata , Jeffrey John Scheibel , David Johnathan Kitko , Jun Xu , Charles Winston Saunders , Kenneth Nathan Price , Stephanie Ann Urbin , Phillip Richard Green
发明人： Jorge Max Sunkel , Toshiyuki Iwata , Jeffrey John Scheibel , David Johnathan Kitko , Jun Xu , Charles Winston Saunders , Kenneth Nathan Price , Stephanie Ann Urbin , Phillip Richard Green
摘要： A rinse-off conditioning composition comprising: (a) near-terminal branched alcohol according to Formula I; (b) a cationic surfactant; (c) a terminal aminosilicone; wherein the near-terminal branched alcohol and the cationic surfactant are comprised in a lamellar gel matrix.
摘要翻译： 洗涤调理组合物，其包含：（a）根据式I的近端支链醇; （b）阳离子表面活性剂; （c）末端氨基硅氧烷; 其中所述近末端支链醇和阳离子表面活性剂包含在层状凝胶基质中。
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10.发明申请Intermediates And Surfactants useful In Household Cleaning And Personal Care Compositions, And Methods Of Making The Same 有权中间体和表面活性剂在家用清洁和个人护理组合物中的应用以及制造方法公开(公告)号：US20110171155A1
公开(公告)日：2011-07-14
申请号：US13004072
申请日：2011-01-11
申请人： Thomas Walter Federle , Jeffrey John Scheibel , Zaiyou Liu , Phillip Kyle Vinson , Howard David Hutton, III , John David Carter , Charles Winston Saunders , Jun Xu , Phillip Richard Green
发明人： Thomas Walter Federle , Jeffrey John Scheibel , Zaiyou Liu , Phillip Kyle Vinson , Howard David Hutton, III , John David Carter , Charles Winston Saunders , Jun Xu , Phillip Richard Green
CPC分类号： C12P7/6409 , C12N9/90 , C12N9/93 , C12Y504/99002 , C12Y604/01003
摘要： Disclosed herein are novel mixtures of scattered-branched chain fatty acids and derivatives of scattered-branched chain fatty acids. Further disclosed are uses of these mixtures in cleaning compositions (e.g., dishcare, laundry, hard surface cleaners,) and/or personal care compositions (e.g., skin cleansers, shampoo, hair conditioners).
摘要翻译： 本文公开了分散支链脂肪酸和分散支链脂肪酸衍生物的新型混合物。 还公开了这些混合物在清洁组合物（例如餐具，衣物，硬表面清洁剂）和/或个人护理组合物（例如，皮肤清洁剂，洗发剂，护发素）中的用途。
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