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公开(公告)号：US10662235B2
公开(公告)日：2020-05-26
申请号：US15629090
申请日：2017-06-21
发明人： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Alastair King , Steven Jacobs , Shalom Goldberg , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
摘要： Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.
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公开(公告)号：US20140162316A1
公开(公告)日：2014-06-12
申请号：US13759526
申请日：2013-02-05
发明人： Karyn O'Neil , Kristen Picha
IPC分类号： C07K16/28
CPC分类号： C07K16/2869 , C07K2317/76
摘要： The present invention relates to antibodies reactive with GLP-1R, and methods of making and using them.
摘要翻译： 本发明涉及与GLP-1R反应的抗体，以及制备和使用它们的方法。
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3.发明申请公开(公告)号：US20140155326A1
公开(公告)日：2014-06-05
申请号：US14086250
申请日：2013-11-21
发明人： Anderson Mark , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
CPC分类号： C07K14/78 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/70
摘要： Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
摘要翻译： 单特异性和双特异性EGFR和/或c-Met FN3结构域分子，编码分子的分离的核苷酸，载体，宿主细胞及其制备方法可用于治疗分子的产生以及疾病和病症的治疗和诊断。
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公开(公告)号：US10954284B2
公开(公告)日：2021-03-23
申请号：US15637276
申请日：2017-06-29
发明人： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
IPC分类号： C07K14/705 , C07K14/78 , C07K14/71 , C07K16/28 , C07K14/47 , A61K45/06 , A61K39/00 , A61K38/00
摘要： Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：US20170362301A1
公开(公告)日：2017-12-21
申请号：US15629090
申请日：2017-06-21
发明人： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Alastair King , Steven Jacobs , Shalom Goldberg , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
IPC分类号： C07K14/78
摘要： Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.
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公开(公告)号：US20170305997A1
公开(公告)日：2017-10-26
申请号：US15637276
申请日：2017-06-29
发明人： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
IPC分类号： C07K14/78 , A61K45/06 , C07K14/47 , C07K14/71 , C07K16/28 , C07K14/705 , A61K39/00 , A61K38/00
CPC分类号： C07K14/78 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/70
摘要： Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：US20200325210A1
公开(公告)日：2020-10-15
申请号：US16840479
申请日：2020-04-06
发明人： Mark Anderson , Ricardo Attar , Michael Diem , Shalom Goldberg , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
摘要： Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.
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公开(公告)号：US20140155325A1
公开(公告)日：2014-06-05
申请号：US14085340
申请日：2013-11-20
发明人： Anderson Mark , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
CPC分类号： C07K14/78 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/70
摘要： Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：US20210206825A1
公开(公告)日：2021-07-08
申请号：US17174524
申请日：2021-02-12
发明人： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
IPC分类号： C07K14/705 , C07K14/78 , C07K14/71 , C07K16/28 , C07K14/47
摘要： Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：US09725497B2
公开(公告)日：2017-08-08
申请号：US14086250
申请日：2013-11-21
发明人： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
IPC分类号： C07K19/00 , C07K14/78 , A61K45/06 , C07K16/28 , C07K14/705 , C07K14/71 , C07K14/47 , A61K38/00 , A61K39/00
CPC分类号： C07K14/78 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/70
摘要： Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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