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公开(公告)号:US07271176B2
公开(公告)日:2007-09-18
申请号:US10487168
申请日:2002-11-13
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号: A01N43/42 , A61K31/44 , C07D401/00 , C07D451/00 , C07D453/00
CPC分类号: C07D211/46 , C07D211/52 , C07D313/12 , C07D401/06 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D495/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由式(1)表示的化合物或其生理学上可接受的盐
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公开(公告)号:US20120046311A1
公开(公告)日:2012-02-23
申请号:US13245436
申请日:2011-09-26
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号: A61K31/4353 , A61P19/02 , A61P9/10 , A61P3/10 , A61P29/00 , A61P25/00 , A61P1/00 , A61P37/08 , A61P11/06 , C07D491/044 , A61P17/06
CPC分类号: C07D519/00 , C07D211/44 , C07D211/46 , C07D211/52 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D497/04 , C07D513/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由其表示的化合物或其生理上可接受的盐。
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公开(公告)号:US20090281081A1
公开(公告)日:2009-11-12
申请号:US12436271
申请日:2009-05-06
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号: A61K31/4523 , C07D211/22 , C07D405/06 , C07D409/06 , C07D401/06 , C07D413/14 , C07D491/044 , A61K31/451 , A61K31/4535 , A61K31/4353 , A61K31/55 , A61K31/5377 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/537 , A61K31/438 , A61P9/00 , A61P29/00 , A61P37/00
CPC分类号: C07D519/00 , C07D211/44 , C07D211/46 , C07D211/52 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D497/04 , C07D513/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由其表示的化合物或其生理上可接受的盐。
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公开(公告)号:US07541365B2
公开(公告)日:2009-06-02
申请号:US11595653
申请日:2006-11-10
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号: A01N43/42 , A61K31/44 , C07D455/04 , C07D491/00 , C07D221/00 , C07D221/06
CPC分类号: C07D519/00 , C07D211/44 , C07D211/46 , C07D211/52 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D497/04 , C07D513/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由其表示的化合物或其生理上可接受的盐。
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公开(公告)号:US07186729B2
公开(公告)日:2007-03-06
申请号:US10487168
申请日:2002-11-13
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号: A01N43/42 , A61K31/44 , C07D401/00 , C07D451/00 , C07D453/00
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof
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公开(公告)号:US08653096B2
公开(公告)日:2014-02-18
申请号:US13245436
申请日:2011-09-26
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号: C07D491/00 , C07D498/00 , C07D515/00 , A01N43/42 , A61K31/44
CPC分类号: C07D519/00 , C07D211/44 , C07D211/46 , C07D211/52 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D497/04 , C07D513/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由其表示的化合物或其生理上可接受的盐。
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公开(公告)号:US08058287B2
公开(公告)日:2011-11-15
申请号:US12436271
申请日:2009-05-06
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号: C07D491/00 , C07D498/00 , C07D515/00 , A01N43/42 , A61K31/44
CPC分类号: C07D519/00 , C07D211/44 , C07D211/46 , C07D211/52 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D497/04 , C07D513/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由其表示的化合物或其生理上可接受的盐。
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8.
公开(公告)号:US20090181966A1
公开(公告)日:2009-07-16
申请号:US12321910
申请日:2009-01-27
申请人: Shomir Ghosh , Amy M. Elder , Kenneth G. Carson , Kevin T. Sprott , Sean J. Harrison , Frederick A. Hicks , Christelle C. Renou , Dominic Reynolds
发明人: Shomir Ghosh , Amy M. Elder , Kenneth G. Carson , Kevin T. Sprott , Sean J. Harrison , Frederick A. Hicks , Christelle C. Renou , Dominic Reynolds
IPC分类号: A61K31/47 , C07D215/42 , A61K31/5377 , A61P37/08 , C07D413/06
CPC分类号: C07D471/04 , A61K31/4353 , A61K31/47 , C07D215/42 , C07D215/44 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/06 , C07D491/04 , C07D495/04
摘要: Disclosed herein are compounds represented by Structural Formula (I) and (I-A): Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply “CRTH2” for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.
摘要翻译: 本文公开的是由结构式(I)和(IA)表示的化合物:还公开了这样的化合物用于抑制称为Th2上表达的化学引诱物受体同源分子的G-蛋白偶联受体,或简称为“CRTH2”,用于 治疗炎症性疾病。 结构式(I)和(I-A)中的变量在本文中定义。
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公开(公告)号:US07504508B2
公开(公告)日:2009-03-17
申请号:US11101208
申请日:2005-04-07
申请人: Shomir Ghosh , Amy M. Elder , Kenneth G. Carson , Kevin T. Sprott , Sean J. Harrison , Frederick A. Hicks , Christelle C. Renou , Dominic Reynolds
发明人: Shomir Ghosh , Amy M. Elder , Kenneth G. Carson , Kevin T. Sprott , Sean J. Harrison , Frederick A. Hicks , Christelle C. Renou , Dominic Reynolds
IPC分类号: C07D215/38
CPC分类号: C07D405/06 , C07D215/42 , C07D215/44 , C07D401/04 , C07D401/06 , C07D401/12 , C07D413/06 , C07D413/10 , C07D417/06
摘要: Disclosed herein are compounds represented by Structural Formula (I) and (I-A): Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply “CRTH2” for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.
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10.
公开(公告)号:US07951950B2
公开(公告)日:2011-05-31
申请号:US11360885
申请日:2006-02-23
申请人: Jeremy D. Little , Shomir Ghosh , Sean Harrison , Amy M. Elder , Christelle C. Renou , Kenneth G. Carson
发明人: Jeremy D. Little , Shomir Ghosh , Sean Harrison , Amy M. Elder , Christelle C. Renou , Kenneth G. Carson
IPC分类号: C07D215/38
CPC分类号: C07D413/12 , C07D215/50 , C07D401/06 , C07D401/12 , C07D409/06 , C07D413/06 , C07D471/04 , C07D495/04
摘要: Disclosed are CRTH2 inhibitors represented by Structural Formula (I): The values for the variables of Structural Formula (I) are provided herein.
摘要翻译: 公开了由结构式(I)表示的CRTH2抑制剂:本文提供了结构式(I)的变量的值。
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