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公开(公告)号：US08900634B2
公开(公告)日：2014-12-02
申请号：US13040143
申请日：2011-03-03
申请人： Je Phil Ryoo , Chun Kwong Chu , Zheng Wang , Diana Shu-Lian Chow , Roland A. Ako
发明人： Je Phil Ryoo , Chun Kwong Chu , Zheng Wang , Diana Shu-Lian Chow , Roland A. Ako
CPC分类号： A61K31/05 , A61K9/006 , A61K9/7007 , A61K31/56
摘要： Oral dosage forms as a biodegradable, water soluble film for delivering pharmaceutically active agents, particularly diethylstilbestrol and pharmaceutically acceptable salts thereof to patients through insertion into the mouth of patient and methods for administering pharmaceutically active agents to patients by insertion into the mouth to provide selective uptake of said agents through the mucosa and thus avoiding the gastrointestinal tract.
摘要翻译： 作为可生物降解的水溶性膜的口服剂型，用于通过插入患者口中向患者输送药物活性剂，特别是己烯雌酚和其药学上可接受的盐，以及通过插入口中向患者施用药物活性剂以提供选择性摄取 的所述药物通过粘膜，从而避免胃肠道。
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公开(公告)号：US20110189288A1
公开(公告)日：2011-08-04
申请号：US13040143
申请日：2011-03-03
申请人： Je Phil Ryoo , Chun Kwong Chu , Zheng Wang , Diana Shu-Lian Chow , Roland A. Ako
发明人： Je Phil Ryoo , Chun Kwong Chu , Zheng Wang , Diana Shu-Lian Chow , Roland A. Ako
CPC分类号： A61K31/05 , A61K9/006 , A61K9/7007 , A61K31/56
摘要： Oral dosage forms as a biodegradable, water soluble film for delivering pharmaceutically active agents, particularly diethylstilbestrol and pharmaceutically acceptable salts thereof to patients through insertion into the mouth of patient and methods for administering pharmaceutically active agents to patients by insertion into the mouth to provide selective uptake of said agents through the mucosa and thus avoiding the gastrointestinal tract.
摘要翻译： 作为可生物降解的水溶性膜的口服剂型，用于通过插入患者口中向患者输送药物活性剂，特别是己烯雌酚和其药学上可接受的盐，以及通过插入口中向患者施用药物活性剂以提供选择性摄取 的所述药物通过粘膜，从而避免胃肠道。
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公开(公告)号：US20100112050A1
公开(公告)日：2010-05-06
申请号：US12608445
申请日：2009-10-29
申请人： Je Phil Ryoo , Chun Kwong Chu , Zheng Wang
发明人： Je Phil Ryoo , Chun Kwong Chu , Zheng Wang
IPC分类号： A61K9/20 , A61K9/00 , A61K47/26 , A61K47/32 , A61K31/404 , A61K31/403 , A61K31/421 , A61K31/454 , A61K31/4196 , A61P25/06
CPC分类号： A61K9/7015 , A61K9/0056 , A61K9/006 , A61K9/0095 , A61K9/2018 , A61K9/2027 , A61K9/7007 , A61K31/00 , A61K31/192 , A61K31/196 , A61K31/4045 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/4439 , A61K31/445 , A61K31/4468 , A61K31/465 , A61K31/495 , A61K31/55 , A61K31/78 , A61K38/05 , A61K38/06 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K2300/00
摘要： Oral dosage forms as a biodegradable, water soluble film for delivering pharmaceutically active agents, particularly anti-migraine agents to patients through insertion into the mouth of patient and methods for administering pharmaceutically active agents to patients by insertion into the mouth to provide selective uptake of said agents through the mucosa and thus avoiding the gastrointestinal tract.
摘要翻译： 口服剂型作为可生物降解的水溶性薄膜，用于通过插入到患者口中向患者输送药物活性剂，特别是抗偏头痛药物，以及通过插入到口腔中向患者施用药物活性剂以提供选择性吸收所述 药剂通过粘膜，从而避免胃肠道。
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公开(公告)号：US08715715B2
公开(公告)日：2014-05-06
申请号：US12608445
申请日：2009-10-29
申请人： Je Phil Ryoo , Chun Kwong Chu , Zheng Wang
发明人： Je Phil Ryoo , Chun Kwong Chu , Zheng Wang
IPC分类号： A61F13/00
CPC分类号： A61K9/7015 , A61K9/0056 , A61K9/006 , A61K9/0095 , A61K9/2018 , A61K9/2027 , A61K9/7007 , A61K31/00 , A61K31/192 , A61K31/196 , A61K31/4045 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/4439 , A61K31/445 , A61K31/4468 , A61K31/465 , A61K31/495 , A61K31/55 , A61K31/78 , A61K38/05 , A61K38/06 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K2300/00
摘要： Oral dosage forms as a biodegradable, water soluble film for delivering pharmaceutically active agents, particularly anti-migraine agents to patients through insertion into the mouth of patient and methods for administering pharmaceutically active agents to patients by insertion into the mouth to provide selective uptake of said agents through the mucosa and thus avoiding the gastrointestinal tract.
摘要翻译： 口服剂型作为可生物降解的水溶性薄膜，用于通过插入到患者口中向患者输送药物活性剂，特别是抗偏头痛药物，以及通过插入到口腔中向患者施用药物活性剂以提供选择性吸收所述 药剂通过粘膜，从而避免胃肠道。
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公开(公告)号：US20100209484A1
公开(公告)日：2010-08-19
申请号：US12704673
申请日：2010-02-12
申请人： Hoo-Kyun Choi , Je Phil Ryoo
发明人： Hoo-Kyun Choi , Je Phil Ryoo
IPC分类号： A61K9/70 , A61K31/422 , A61P25/06
CPC分类号： A61K9/7038 , A61K31/422
摘要： This invention relates to transdermal system for the systemic administration of an active ingredient such as a triptan selected from the group comprising eletriptan, frovatriptan, sumatriptan, zolmitriptan, naratriptan, rizatriptan and almotriptan uniformly over periods of 12 to 24 hours or more thereby reducing the probability of recurring migraine. The formulation includes active ingredient, adhesive matrix and permeation enhancer. The invention also relates to storage stable formulations and methods for preventing migraine and cessation of an ongoing migraine event.
摘要翻译： 本发明涉及在12-24小时或更长时间内均匀地全身施用活性成分例如选自伊曲坦，氟伐他汀，舒马曲坦，佐米曲坦，奈拉曲坦，利扎曲坦和阿莫曲坦的曲坦类的透皮系统，从而降低概率 复发性偏头痛。 制剂包括活性成分，粘合剂基质和渗透促进剂。 本发明还涉及用于预防偏头痛和停止的偏头痛事件的储存稳定制剂和方法。
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6.发明申请公开(公告)号：US20070264319A1
公开(公告)日：2007-11-15
申请号：US11661334
申请日：2005-09-01
申请人： David Lebo , Juny Lee , Je Phil Ryoo , Oliver Toigo , Francis Cupo
发明人： David Lebo , Juny Lee , Je Phil Ryoo , Oliver Toigo , Francis Cupo
CPC分类号： A61K9/7061
摘要： A transdermal antiemesis system, preferably in the form of a drug-in-adhesive matrix patch, is disclosed comprising an effective antiemesis amount of a selective serotonin (5-HT3) receptor antagonist as an antiemetic incorporated in a skin adhesive composition containing at least one permeation enhancer and a water-insoluble pressure-sensitive adhesive. A preferred antiemetic is granisetron base. The transdermal antiemesis system of this invention provides controlled release of the active antiemetic ingredient from the skin-contacting adhesive formulation of a transderrnal patch, and maintains a sustained transdermal delivery of the antiemetic.
摘要翻译： 公开了一种透皮止血系统，优选为药物 - 粘合剂基质贴剂的形式，其包含有效的止血量的选择性5-羟色胺（5-HT 3 N）受体拮抗剂作为掺入的止吐剂 含有至少一种渗透促进剂和水不溶性压敏粘合剂的皮肤粘合剂组合物。 优选的止吐剂是格拉司琼碱。 本发明的透皮止血系统提供活性止吐成分从经皮片的皮肤接触粘合剂制剂的控制释放，并维持止吐剂的持续透皮递送。
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公开(公告)号：US20140302118A1
公开(公告)日：2014-10-09
申请号：US14240980
申请日：2012-08-24
申请人： Naohisa Kawamura , Je Phil Ryoo
发明人： Naohisa Kawamura , Je Phil Ryoo
IPC分类号： A61K31/167 , A61K47/10 , A61K9/70
CPC分类号： A61K47/10 , A61K9/7061 , A61K31/167
摘要： The purpose of the present invention is to provide a hydrous adhesive skin patch which contains lidocaine and can be applied in a uniform thickness easily. This hydrous adhesive skin patch comprises a support and an adhesive agent layer arranged on the support, wherein lidocaine or a pharmacologically acceptable salt thereof, a hydrophilic adhesive agent, and diethylene glycol or a diethylene glycol monoalkyl ether are contained in the adhesive agent layer. The diethylene glycol monoalkyl ether is preferably at least one compound selected from the group consisting of diethylene glycol monomethyl ether, diethylene glycol monoethyl ether and diethylene glycol monobutyl ether.
摘要翻译： 本发明的目的是提供含有利多卡因的含水粘合剂皮肤贴片，并且可以容易地以均匀的厚度涂敷。 这种含水粘合剂皮肤贴剂包括载体和布置在载体上的粘合剂层，其中在粘合剂层中包含利多卡因或其药理学上可接受的盐，亲水性粘合剂和二甘醇或二甘醇单烷基醚。 二甘醇单烷基醚优选为选自二甘醇单甲醚，二甘醇单乙醚和二甘醇单丁醚中的至少一种化合物。
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公开(公告)号：US06733786B1
公开(公告)日：2004-05-11
申请号：US09926590
申请日：2001-11-21
申请人： Nam Joong Kim , Je Phil Ryoo
发明人： Nam Joong Kim , Je Phil Ryoo
IPC分类号： A61K914
CPC分类号： A61K38/27
摘要： The present invention relates to an improved somatotropin composition consisting of somatotropin having in vivo, at least one of lipid-soluble vitamins and at least one of pharmaceutically acceptable lubricants, which improves poor syringeability under cold temperature which has been a defect of the conventional somatotropin formulation using vitamins, and which shows at least the equivalent effect to that of the conventional formulation.
摘要翻译： 本发明涉及一种改良的生长激素组合物，其包括体内生长激素，脂溶性维生素和至少一种药学上可接受的润滑剂中的至少一种，其在冷温度下改善了较差的可注射性，这是常规生长激素制剂的缺陷 使用维生素，并且至少显示与常规制剂的效果相当的效果。
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