公开(公告)号：US06215021B1

公开(公告)日：2001-04-10

申请号：US09335857

申请日：1999-06-17

申请人： Jean'ne M. Shreeve ,  Jing-Jing Yang ,  Robert L. Kirchmeier

发明人： Jean'ne M. Shreeve ,  Jing-Jing Yang ,  Robert L. Kirchmeier

IPC分类号： C07C30900

CPC分类号： C07C381/12

摘要： A family of electrophilic trifluoromethylating reagents which can be synthesized by comparatively simple, inexpensive routes, and for which the reactivity can be varied according to need. A composition of matter according to the first embodiment of the invention comprises a compound having the formula: in which A comprises H or F and B comprises F, SCF3, OCF3, OCHF2, S+(CF3)C6H5, NO2 or an NO2 substituent. In a second embodiment of the invention, a process for preparing a trifluoromethyl diphenylsulfonium triflate compound corresponding to the formula shown above comprises reacting phenyl trifluoromethyl sulfoxide or one of its derivatives with an aromatic compound in which A comprises H or F and B comprises H, F, SCF3, OCF3, OCHF2, S+(CF3)C6H5, NO2 or an NO2 substituent. In a third embodiment of the invention, a trifluoromethylation process comprises reacting a trifluoromethyl diphenylsulfonium triflate corresponding to the formula shown above with an electron rich substrate.

摘要翻译： 一种亲电的三氟甲基化试剂，可以通过相对简单，便宜的途径合成，并且可以根据需要改变反应性。 根据本发明第一实施方案的物质组合物包含具有下式的化合物：其中A包含H或F，B包含F，SCF 3，OCF 3，OCHF 2，S +（CF 3）C 6 H 5，NO 2或NO 2取代基。 在本发明的第二个实施方案中，制备对应于上述式的三氟甲基二苯基锍三氟甲磺酸酯化合物的方法包括使苯基三氟甲基亚砜或其衍生物之一与芳族化合物反应，其中A包含H或F，B包括H，F ，SCF 3，OCF 3，OCHF 2，S +（CF 3）C 6 H 5，NO 2或NO 2取代基。 在本发明的第三个实施方案中，三氟甲基化方法包括使对应于上述式的三氟甲基二苯基锍三氟甲磺酸酯与富含电子的基质反应。