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公开(公告)号:US20090181034A1
公开(公告)日:2009-07-16
申请号:US12397992
申请日:2009-03-04
申请人: Jean GUDAS , Aya Jakobovits , Xiao-Chi Jia , Robert Kendall Morrison , Karen Jene Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
发明人: Jean GUDAS , Aya Jakobovits , Xiao-Chi Jia , Robert Kendall Morrison , Karen Jene Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
IPC分类号: A61K39/395 , C12Q1/68 , A61P35/00
CPC分类号: A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/505 , A61K2039/53 , A61K2039/545 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/34 , C07K2317/73 , C07K2317/734 , C07K2317/77 , G01N33/566 , G01N33/57415 , G01N33/57434 , G01N33/57492 , G01N2500/04
摘要: Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
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公开(公告)号:US20110262968A1
公开(公告)日:2011-10-27
申请号:US13094730
申请日:2011-04-26
申请人: Jean GUDAS , Aya Jakobovits , Xiao-Chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
发明人: Jean GUDAS , Aya Jakobovits , Xiao-Chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
CPC分类号: C07K14/4748 , A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/53 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/73 , G01N33/566 , G01N33/57415 , Y02A50/466
摘要: Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译: 其中PSCA在正常成人组织中表现出组织特异性表达,并且在表I中列出的癌症中异常表达。因此,PSCA提供诊断,预后, 癌症的预防和/或治疗靶标。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号:US20130041138A1
公开(公告)日:2013-02-14
申请号:US13631699
申请日:2012-09-28
申请人: Jean GUDAS , Aya Jakobovits , Xiao-chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
发明人: Jean GUDAS , Aya Jakobovits , Xiao-chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
IPC分类号: C07K16/30
CPC分类号: C07K14/4748 , A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/53 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/73 , G01N33/566 , G01N33/57415 , Y02A50/466
摘要: Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译: 其中PSCA在正常成人组织中表现出组织特异性表达,并且在表I中列出的癌症中异常表达。因此,PSCA提供诊断,预后, 癌症的预防和/或治疗靶标。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号:US20090202548A1
公开(公告)日:2009-08-13
申请号:US12413435
申请日:2009-03-27
申请人: Jean GUDAS , Aya Jakobovits , Xiao-Chi Jia , Robert Kendall Morrison , Pia M. Challita-Eid , Arthur B. Raitano
发明人: Jean GUDAS , Aya Jakobovits , Xiao-Chi Jia , Robert Kendall Morrison , Pia M. Challita-Eid , Arthur B. Raitano
IPC分类号: A61K39/395 , C12N5/02 , G01N33/574
CPC分类号: G01N33/57492 , A61K39/0011 , A61K47/6869 , A61K49/0002 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/505 , A61K2039/53 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/21 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , G01N33/566 , G01N33/57415 , G01N33/57434 , G01N33/57484 , G01N2500/04
摘要: Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译: 其中PSCA在正常成人组织中表现出组织特异性表达,并且在表I中列出的癌症中异常表达。因此,PSCA提供诊断,预后, 癌症的预防和/或治疗靶标。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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