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    Polypeptides derived from RNA polymerases and use thereof
    1.
    发明授权
    Polypeptides derived from RNA polymerases and use thereof 有权
    衍生自RNA聚合酶的多肽及其用途

    公开(公告)号：US07335471B2

    公开(公告)日：2008-02-26

    申请号：US10472146

    申请日：2002-03-19

    申请人： Jean Guillerez ,  Pascal Lopez ,  Marc Dreyfus

    发明人： Jean Guillerez ,  Pascal Lopez ,  Marc Dreyfus

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12N9/1247 ,  C12P21/00

    摘要： Mutant RNA polymerases of phagic origin in which the peptide chain is modified by substitution, deletion or addition of at least one amino acid, the modification having the effect of reducing the sensitivity of the RNA polymerases to the initial transcription sequence of the DNA sequence coding for the RNA, for a method for production of the RNA, or proteins coded by the RNA, from given nucleotide sequences, comprising a sequence of DNA coding for the RNA, the transcription of which is placed under the control of a promoter recognised by wild-type RNA polymerases and the mutant RNA polymerases as above. The method has a higher yield of RNA than the yield obtained when using the wild-type RNA polymerases in the presence of the same non-consensual ITS as that found in the sequence of DNA coding for the RNA.

    摘要翻译： 通过取代，缺失或添加至少一个氨基酸来修饰肽链的突变型RNA聚合酶，所述修饰具有降低RNA聚合酶对于编码DNA聚合酶的DNA序列的初始转录序列的敏感性的作用 RNA，用于生产RNA的方法或由RNA编码的蛋白质，从给定的核苷酸序列，包括编码RNA的DNA序列，其转录置于由野生型识别的启动子的控制下， RNA聚合酶和突变型RNA聚合酶。 该方法在使用野生型RNA聚合酶时在与编码RNA的DNA序列相同的非自愿ITS存在下获得的产量高于RNA产量。

    Mutant E. coli strains, and their use for producing recombinant polypeptides
    2.
    发明授权
    Mutant E. coli strains, and their use for producing recombinant polypeptides 有权
    突变大肠杆菌菌株及其用于产生重组多肽的用途

    公开(公告)号：US06632639B1

    公开(公告)日：2003-10-14

    申请号：US09762481

    申请日：2001-05-17

    申请人： Marc Dreyfus ,  Pascal Lopez

    发明人： Marc Dreyfus ,  Pascal Lopez

    IPC分类号： C12P2102

    CPC分类号： C12N9/22 ,  C12N15/70

    摘要： The invention concerns the use of Escherichia coli (E. coli) strains whereof the gene coding for the Rnase E comprises a mutation such that the enzyme produced when said mutated gene is expressed no longer has a degrading activity on mRNA, said mutation more significantly not affecting the growth of E. coli strains, for implementing a method for producing specific exogenous recombinant polypeptides.

    摘要翻译： 本发明涉及使用编码Rnase E的基因包含一个或多个氨基酸序列的大肠杆菌（Escherichia coli），大肠杆菌（Escherichia coli），大肠杆菌（Escherichia coli） 突变，使得当所述突变基因被表达时产生的酶不再具有对mRNA的降解活性，所述突变更显着地不影响 E的生长。 大肠杆菌 菌株，用于实施用于产生特异性外源重组多肽的方法。

    EXPERTISE REFERRALS USING A REAL-TIME COMMUNICATION SYSTEM
    3.
    发明申请
    EXPERTISE REFERRALS USING A REAL-TIME COMMUNICATION SYSTEM 有权
    使用实时通信系统的专业引用

    公开(公告)号：US20100169426A1

    公开(公告)日：2010-07-01

    申请号：US12345709

    申请日：2008-12-30

    申请人： Marc Dreyfus ,  Asima Silva ,  Robert C. Weir ,  Derek S. Lam

    发明人： Marc Dreyfus ,  Asima Silva ,  Robert C. Weir ,  Derek S. Lam

    IPC分类号： G06F15/16

    CPC分类号： G06Q30/02

    摘要： A computer-implemented method of providing expertise based referrals can include receiving, from a first user, a voucher specifying a second user seeking expertise and a third user as a potential subject matter expert. Responsive to execution of the voucher, an instant messaging session between the second user and the third user can be established and an input from the second user indicating whether a posed question from the second user is resolved can be received. When the posed question is resolved, a role of maven can be assigned to the first user and a role of subject matter expert can be assigned to the third user. A transcript of the instant messaging session between the second user and the third user, a reference to the first user with the assigned role, and a reference to the third user with the assigned role can be stored as part of a referral transaction.

    摘要翻译： 提供基于专业知识的推荐的计算机实现的方法可以包括从第一用户接收指定寻求专业知识的第二用户的凭证和作为潜在主题专家的第三用户。 响应于凭证的执行，可以建立第二用户和第三用户之间的即时消息会话，并且可以接收来自第二用户的指示是否解决来自第二用户的提问的问题的输入。 当提出的问题得到解决时，可以将第一用户的角色定义为maven，并且可以向第三用户分配主题专家的角色。 第二用户和第三用户之间的即时消息传递会话的记录，对具有分配角色的第一用户的引用以及对具有分配角色的第三用户的引用可被存储为推荐事务的一部分。

    Expertise referrals using a real-time communication system
    4.
    发明授权
    Expertise referrals using a real-time communication system 有权
    使用实时通信系统的专长推荐

    公开(公告)号：US08468194B2

    公开(公告)日：2013-06-18

    申请号：US12345709

    申请日：2008-12-30

    申请人： Marc Dreyfus ,  Asima Silva ,  Robert C. Weir ,  Derek S. Lam

    发明人： Marc Dreyfus ,  Asima Silva ,  Robert C. Weir ,  Derek S. Lam

    IPC分类号： G06F15/16

    CPC分类号： G06Q30/02

    摘要： A computer-implemented method of providing expertise based referrals can include receiving, from a first user, a voucher specifying a second user seeking expertise and a third user as a potential subject matter expert. Responsive to execution of the voucher, an instant messaging session between the second user and the third user can be established and an input from the second user indicating whether a posed question from the second user is resolved can be received. When the posed question is resolved, a role of maven can be assigned to the first user and a role of subject matter expert can be assigned to the third user. A transcript of the instant messaging session between the second user and the third user, a reference to the first user with the assigned role, and a reference to the third user with the assigned role can be stored as part of a referral transaction.

    摘要翻译： 提供基于专业知识的推荐的计算机实现的方法可以包括从第一用户接收指定寻求专业知识的第二用户的凭证和作为潜在主题专家的第三用户。 响应于凭证的执行，可以建立第二用户和第三用户之间的即时消息会话，并且可以接收来自第二用户的指示是否解决来自第二用户的提问的问题的输入。 当提出的问题得到解决时，可以将第一用户的角色定义为maven，并且可以向第三用户分配主题专家的角色。 第二用户和第三用户之间的即时消息传递会话的记录，对具有分配角色的第一用户的引用以及对具有分配角色的第三用户的引用可被存储为推荐事务的一部分。

    Enhanced spell checking utilizing a social network
    9.
    发明申请
    Enhanced spell checking utilizing a social network 审中-公开
    使用社交网络增强拼写检查

    公开(公告)号：US20090254817A1

    公开(公告)日：2009-10-08

    申请号：US12061685

    申请日：2008-04-03

    申请人： Marc Dreyfus ,  Derek S. Lam ,  Asima Silva ,  Robert C. Weir

    发明人： Marc Dreyfus ,  Derek S. Lam ,  Asima Silva ,  Robert C. Weir

    IPC分类号： G06F17/24

    CPC分类号： G06F17/273 ,  G06F17/2735

    摘要： A computer-implemented method of enhancing spell check. The method can include receiving from each of a plurality of clients at least one custom term and at least one class identifier that is associated with the custom term. The custom terms and the associated class identifiers can be processed to provide an electronic dictionary that includes a plurality of shared terms. Each of the shared terms can be associated with at least one of the class identifiers to which the shared term corresponds. Each of the custom terms can correspond to at least one of the shared terms. At least one of the shared terms can be output to at least one of the plurality of clients.

    摘要翻译： 一种加强拼写检查的电脑实现方法。 该方法可以包括从多个客户端中的每一个接收至少一个自定义术语和与自定义术语相关联的至少一个类标识符。 可以处理自定义术语和相关联的类标识符以提供包括多个共享术语的电子词典。 每个共享术语可以与共享术语对应的类标识符中的至少一个相关联。 每个自定义术语可以对应于至少一个共享术语。 共享术语中的至少一个可以被输出到多个客户端中的至少一个。

    PERFORMANCE OF TEMPLATE BASED JAVASCRIPT WIDGETS
    10.
    发明申请
    PERFORMANCE OF TEMPLATE BASED JAVASCRIPT WIDGETS 审中-公开
    基于模板的JAVASCRIPT WIDGETS的性能

    公开(公告)号：US20110161840A1

    公开(公告)日：2011-06-30

    申请号：US12647142

    申请日：2009-12-24

    申请人： Cesar Augusto Wong ,  Morgan Louis Johnson ,  Marc Dreyfus ,  Asima Silva

    发明人： Cesar Augusto Wong ,  Morgan Louis Johnson ,  Marc Dreyfus ,  Asima Silva

    IPC分类号： G06F3/00

    CPC分类号： G06F17/30893 ,  G06F8/35 ,  G06F8/38

    摘要： Included are method, article of manufacture, and device that serve to embed a universal script object into programming code used for rendering a web page, convert the universal script object into JavaScript, and upon receiving a request for a web page, send the converted and embedded universal script object towards a requestor. The universal script object may be converted from HTML or some other language.

    摘要翻译： 包括方法，制品和设备，用于将通用脚本对象嵌入到用于呈现网页的编程代码中，将通用脚本对象转换为JavaScript，并且在接收到对网页的请求时，发送转换和 嵌入通用脚本对象到请求者。 通用脚本对象可以从HTML或其他语言转换。