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    Acetophenone potentiators of metabotropic glutamate receptors
    7.
    发明申请
    Acetophenone potentiators of metabotropic glutamate receptors 审中-公开
    代谢型谷氨酸受体的苯乙酮增效剂

    公开(公告)号：US20050288346A1

    公开(公告)日：2005-12-29

    申请号：US10524704

    申请日：2003-08-22

    申请人： Rowena Cube ,  Anthony Pinkerton ,  Jean-Michel Vernier ,  Xiumin Zhao

    发明人： Rowena Cube ,  Anthony Pinkerton ,  Jean-Michel Vernier ,  Xiumin Zhao

    IPC分类号： A61K31/41 ,  A61P25/00 ,  C07D257/02 ,  C07D257/04

    CPC分类号： C07D257/04

    摘要： The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

    摘要翻译： 本发明涉及作为代谢型谷氨酸受体的增强剂（包括mGluR2受体）的化合物，其可用于治疗或预防与谷氨酸能力障碍相关的神经和精神病学障碍以及其中涉及代谢型谷氨酸受体的疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及代谢型谷氨酸受体的疾病中的用途。

    Purines as reverse transcriptase inhibitors
    9.
    发明授权
    Purines as reverse transcriptase inhibitors 失效
    嘌呤作为逆转录酶抑制剂

    公开(公告)号：US08372852B2

    公开(公告)日：2013-02-12

    申请号：US13470122

    申请日：2012-05-11

    申请人： Alex Shaginian ,  Samedy Ouk ,  Jean-Michel Vernier ,  Anthony B. Pinkerton

    发明人： Alex Shaginian ,  Samedy Ouk ,  Jean-Michel Vernier ,  Anthony B. Pinkerton

    IPC分类号： C07D473/28 ,  C07D473/34 ,  A61K31/52 ,  A61P31/18 ,  C07D487/04 ,  A61K31/519

    CPC分类号： C07D487/04 ,  C07D473/18

    摘要： Described herein are novel enzyme inhibitors. In some embodiments, the enzyme inhibitors are reverse transcriptase inhibitors, particularly HIV reverse transcriptase inhibitors. Also described herein are compositions containing them and methods of using them. Thus, the compounds and compositions described herein are useful for the in vitro and in vivo inhibition of HIV reverse transcriptase as a method of treating or preventing HIV, AIDS or related disorders. In some embodiments, the enzyme inhibitors are compounds of formula (I) or a pharmaceutically acceptable salt or tautomer thereof:

    摘要翻译： 本文描述的是新的酶抑制剂。 在一些实施方案中，酶抑制剂是逆转录酶抑制剂，特别是HIV逆转录酶抑制剂。 本文还描述了含有它们的组合物和使用它们的方法。 因此，本文所述的化合物和组合物可用于体外和体内抑制HIV逆转录酶，作为治疗或预防HIV，AIDS或相关病症的方法。 在一些实施方案中，酶抑制剂是式（I）的化合物或其药学上可接受的盐或互变异构体：