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    3-Nitrogen-6, 7-dioxygen steroids and uses related thereto
    2.
    发明申请
    3-Nitrogen-6, 7-dioxygen steroids and uses related thereto 失效
    3-氮-6,7-二氧类固醇及其相关用途

    公开(公告)号：US20050215534A9

    公开(公告)日：2005-09-29

    申请号：US10624946

    申请日：2003-07-21

    申请人： Jeffery Raymond ,  Claudia Kasserra ,  Yaping Shen

    发明人： Jeffery Raymond ,  Claudia Kasserra ,  Yaping Shen

    IPC分类号： A61K31/56 ,  A61K31/566 ,  A61K31/57 ,  A61K31/58 ,  A61P9/06 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P17/02 ,  A61P29/00 ,  A61P31/18 ,  A61P35/00 ,  A61P37/08 ,  A61P43/00 ,  C07J41/00 ,  C07J43/00 ,  C07J71/00

    CPC分类号： C07J41/00 ,  C07J41/0005 ,  C07J41/0011 ,  C07J43/00 ,  C07J71/0047 ,  C07J71/0063 ,  Y02P20/55

    摘要： A compound of the formula and pharmaceutically acceptable salts, solvates, stereoisomers and prodrugs thereof, in isolation or in mixture, wherein, independently at each occurrence: R1 and R2 are selected from hydrogen, oxygen so as to form nitro or oxime, amino, sulfate, and sulfonic acid, and organic groups having 1-30 carbons and optionally containing 1-6 heteroatoms selected from nitrogen, oxygen, phosphorous, silicon, and sulfur, where R1 and R2 may, together with the N to which they are both bonded, form a heterocyclic structure that may be part of an organic group having 1-30 carbons and optionally containing 1-6 heteroatoms selected from nitrogen, oxygen and silicon, and where R1 may be a 2, or 3 atom chain to numeral 2 so that —N—R1— forms part of a fused bicyclic structure to ring A; R3 and R4 are selected from direct bonds to 6 and 7 respectively so as to form carbonyl groups, hydrogen, or a protecting group such that R3 and/or R4 is part of hydroxyl or carbonyl protecting group; numerals 1 through 17 each represent a carbon having substitution as described. The compounds may be formulated into pharmaceutical compositions, and used in the treatment and/or prevention of various conditions, including inflammation, asthma, an allergic disease, chronic obstructive pulmonary disease, atopic dermatitis, solid tumors, AIDS, ischemia, and cardiac arrhythmias.

    摘要翻译： R 1和R 2各自独立地是分别地或以混合物形式的式及其药学上可接受的盐，溶剂合物，立体异构体和前药的化合物，其中每次出现：R 1和 选自氢，氧，以形成硝基或肟，氨基，硫酸根和磺酸，以及具有1-30个碳原子并且任选地含有1-6个选自氮，氧，磷，硅和硫的杂原子的有机基团，其中 R 1和R 2可以与它们都键合的N一起形成可以是具有1-30个碳的有机基团的一部分的杂环结构，以及 任选地含有1-6个选自氮，氧和硅的杂原子，并且其中R 1可以是2或3个原子链至2，使得-NR 1 - 形成环A的稠合双环结构的一部分; R 3和R 4分别选自6和7的直接键，以便形成羰基，氢或保护基，使得R 3， 和/或R 4是羟基或羰基保护基的一部分; 数字1至17各自表示如上所述具有取代的碳。 化合物可以配制成药物组合物，并用于治疗和/或预防各种病症，包括炎症，哮喘，过敏性疾病，慢性阻塞性肺病，特应性皮炎，实体瘤，AIDS，局部缺血和心律失常。

    3-Nitrogen-6,7-dioxygen steroids and uses related thereto
    3.
    发明申请
    3-Nitrogen-6,7-dioxygen steroids and uses related thereto 审中-公开
    3-氮-6,7-二氧类固醇及其相关用途

    公开(公告)号：US20070060553A1

    公开(公告)日：2007-03-15

    申请号：US11496052

    申请日：2006-07-28

    申请人： Jeffery Raymond ,  Claudia Kasserra ,  Yaping Shen

    发明人： Jeffery Raymond ,  Claudia Kasserra ,  Yaping Shen

    IPC分类号： C07J43/00 ,  C07J41/00 ,  A61K31/58 ,  A61K31/56

    CPC分类号： C07J41/00 ,  C07J41/0005 ,  C07J41/0011 ,  C07J43/00 ,  C07J71/0047 ,  C07J71/0063 ,  Y02P20/55

    摘要： A compound of the formula and pharmaceutically acceptable salts, solvates, stereoisomers and prodrugs thereof, in isolation or in mixture, wherein, independently at each occurrence: R1 and R2 are selected from hydrogen, oxygen so as to form nitro or oxime, amino, sulfate, and sulfonic acid, and organic groups having 1-30 carbons and optionally containing 1-6 heteroatoms selected from nitrogen, oxygen, phosphorous, silicon, and sulfur, where R1 and R2 may, together with the N to which they are both bonded, form a heterocyclic structure that may be part of an organic group having 1-30 carbons and optionally containing 1-6 heteroatoms selected from nitrogen, oxygen and silicon, and where R1 may be a 2, or 3 atom chain to numeral 2 so that —N—R1— forms part of a fused bicyclic structure to ring A; R3 and R4 are selected from direct bonds to 6 and 7 respectively so as to form carbonyl groups, hydrogen, or a protecting group such that R3 and/or R4 is part of hydroxyl or carbonyl protecting group; numerals 1 through 17 each represent a carbon having substitution as described. The compounds may be formulated into pharmaceutical compositions, and used in the treatment and/or prevention of various conditions, including inflammation, asthma, an allergic disease, chronic obstructive pulmonary disease, atopic dermatitis, solid tumors, AIDS, ischemia, and cardiac arrhythmias.

    摘要翻译： R 1和R 2各自独立地是分别地或以混合物形式的式及其药学上可接受的盐，溶剂合物，立体异构体和前药的化合物，其中每次出现：R 1和 选自氢，氧，以形成硝基或肟，氨基，硫酸根和磺酸，以及具有1-30个碳原子并且任选地含有1-6个选自氮，氧，磷，硅和硫的杂原子的有机基团，其中 R 1和R 2可以与它们都键合的N一起形成可以是具有1-30个碳的有机基团的一部分的杂环结构，以及 任选地含有1-6个选自氮，氧和硅的杂原子，并且其中R 1可以是2或3个原子链至2，使得-NR 1 - 形成环A的稠合双环结构的一部分; R 3和R 4分别选自6和7的直接键，以便形成羰基，氢或保护基，使得R 3， 和/或R 4是羟基或羰基保护基的一部分; 数字1至17各自表示如上所述具有取代的碳。 化合物可以配制成药物组合物，并用于治疗和/或预防各种病症，包括炎症，哮喘，过敏性疾病，慢性阻塞性肺病，特应性皮炎，实体瘤，AIDS，局部缺血和心律失常。