公开(公告)号：US06921603B2

公开(公告)日：2005-07-26

申请号：US10131846

申请日：2002-04-24

申请人： Jeffrey D. Morse ,  Klint A Rose ,  Mariam Maghribi ,  William Benett ,  Peter Krulevitch ,  Julie Hamilton ,  Robert T. Graff ,  Alan Jankowski

发明人： Jeffrey D. Morse ,  Klint A Rose ,  Mariam Maghribi ,  William Benett ,  Peter Krulevitch ,  Julie Hamilton ,  Robert T. Graff ,  Alan Jankowski

IPC分类号： B01D65/00 ,  B01D67/00 ,  B01D71/70 ,  H01M4/86 ,  H01M8/00 ,  H01M8/02 ,  H01M8/04 ,  H01M8/10

CPC分类号： B01D67/0034 ,  B01D65/003 ,  B01D67/0032 ,  B01D71/70 ,  B01D2323/24 ,  B01D2325/028 ,  B01D2325/08 ,  H01M8/0239 ,  H01M8/0245 ,  H01M8/04037 ,  H01M8/04089 ,  H01M8/1007 ,  H01M8/1097 ,  Y10T29/49114

摘要： Described herein is a process for fabricating microfluidic systems with embedded components in which micron-scale features are molded into the polymeric material polydimethylsiloxane (PDMS). Micromachining is used to create a mold master and the liquid precursors for PDMS are poured over the mold and allowed to cure. The PDMS is then removed form the mold and bonded to another material such as PDMS, glass, or silicon after a simple surface preparation step to form sealed microchannels.

摘要翻译： 本文描述了一种用于制造具有嵌入组件的微流体系统的方法，其中将微米级特征模制成聚合物材料聚二甲基硅氧烷（PDMS）。 微加工用于制造模具主体，将PDMS的液体前体倒在模具上并使其固化。 然后在简单的表面制备步骤之后，从模具中除去PDMS并结合到另一种材料如PDMS，玻璃或硅，以形成密封的微通道。

公开(公告)号：US07186352B2

公开(公告)日：2007-03-06

申请号：US10853859

申请日：2004-05-25

申请人： Jeffrey D. Morse ,  Klint A Rose ,  Mariam Maghribi ,  William Benett ,  Peter Krulevitch ,  Julie Hamilton ,  Robert T. Graff ,  Alan Jankowski

发明人： Jeffrey D. Morse ,  Klint A Rose ,  Mariam Maghribi ,  William Benett ,  Peter Krulevitch ,  Julie Hamilton ,  Robert T. Graff ,  Alan Jankowski

IPC分类号： H01M8/00

CPC分类号： B01D67/0034 ,  B01D65/003 ,  B01D67/0032 ,  B01D71/70 ,  B01D2323/24 ,  B01D2325/028 ,  B01D2325/08 ,  H01M8/0239 ,  H01M8/0245 ,  H01M8/04037 ,  H01M8/04089 ,  H01M8/1007 ,  H01M8/1097 ,  Y10T29/49114

摘要： Described herein is a process for fabricating microfluidic systems with embedded components in which micron-scale features are molded into the polymeric material polydimethylsiloxane (PDMS). Micromachining is used to create a mold master and the liquid precursors for PDMS are poured over the mold and allowed to cure. The PDMS is then removed form the mold and bonded to another material such as PDMS, glass, or silicon after a simple surface preparation step to form sealed microchannels.

摘要翻译： 本文描述了一种用于制造具有嵌入组件的微流体系统的方法，其中将微米级特征模制成聚合物材料聚二甲基硅氧烷（PDMS）。 微加工用于制造模具主体，将PDMS的液体前体倒在模具上并使其固化。 然后在简单的表面制备步骤之后，从模具中除去PDMS并结合到另一种材料如PDMS，玻璃或硅，以形成密封的微通道。

公开(公告)号：US20060113537A1

公开(公告)日：2006-06-01

申请号：US11326967

申请日：2006-01-05

申请人： Peter Krulevitch ,  Mariam Maghribi ,  William Benett ,  Julie Hamilton ,  Klint Rose ,  James Davidson ,  Mark Strauch

发明人： Peter Krulevitch ,  Mariam Maghribi ,  William Benett ,  Julie Hamilton ,  Klint Rose ,  James Davidson ,  Mark Strauch

IPC分类号： H01L31/0376

CPC分类号： H01L25/165 ,  B81C1/0023 ,  H01L21/6835 ,  H01L31/048 ,  H01L31/0543 ,  H01L2221/68345 ,  H01L2924/0002 ,  H01L2924/09701 ,  H01L2924/19041 ,  H01L2924/19105 ,  Y02E10/52 ,  H01L2924/00

摘要： A peel and stick electronic system comprises a silicone body, and at least one electronic unit operatively connected to the silicone body. The electronic system is produce by providing a silicone layer on a substrate, providing a metal layer on the silicone layer, and providing at least one electronic unit connected to the metal layer.

公开(公告)号：US20050136639A1

公开(公告)日：2005-06-23

申请号：US10742112

申请日：2003-12-18

申请人： J. Davidson ,  Peter Krulevitch ,  Mariam Maghribi ,  Julie Hamilton ,  William Benett ,  Armando Tovar

发明人： J. Davidson ,  Peter Krulevitch ,  Mariam Maghribi ,  Julie Hamilton ,  William Benett ,  Armando Tovar

IPC分类号： H01L21/44 ,  H01L21/768 ,  H05K3/40

CPC分类号： H01L21/76838 ,  H05K3/4053 ,  H05K2203/0195 ,  H05K2203/0338 ,  Y10T29/49155

摘要： A system for metalization of an integrated microsystem. The system comprises providing a substrate and applying a conductive material to the substrate by taking up small aliquots of conductive material and releasing the conductive material onto the substrate to produce a circuit component.

摘要翻译： 一个集成微系统的金属化系统。 该系统包括提供衬底并且通过吸收导电材料的小等分试样并将导电材料释放到衬底上以产生电路部件而将导电材料施加到衬底。

公开(公告)号：US07601286B2

公开(公告)日：2009-10-13

申请号：US10107933

申请日：2002-03-26

申请人： William Benett ,  Peter Krulevitch ,  Mariam Maghribi ,  Julie Hamilton ,  Klint Rose ,  Amy W. Wang

发明人： William Benett ,  Peter Krulevitch ,  Mariam Maghribi ,  Julie Hamilton ,  Klint Rose ,  Amy W. Wang

IPC分类号： B29C33/76

CPC分类号： B29C39/10 ,  B29C33/3842 ,  B29C39/34 ,  B29K2083/00 ,  B29K2083/005 ,  B29L2031/24 ,  B29L2031/756

摘要： A method of forming a polymer-based microfluidic system platform using network building blocks selected from a set of interconnectable network building blocks, such as wire, pins, blocks, and interconnects. The selected building blocks are interconnectably assembled and fixedly positioned in precise positions in a mold cavity of a mold frame to construct a three-dimensional model construction of a microfluidic flow path network preferably having meso-scale dimensions. A hardenable liquid, such as poly (dimethylsiloxane) is then introduced into the mold cavity and hardened to form a platform structure as well as to mold the microfluidic flow path network having channels, reservoirs and ports. Pre-fabricated elbows, T's and other joints are used to interconnect various building block elements together. After hardening the liquid the building blocks are removed from the platform structure to make available the channels, cavities and ports within the platform structure. Microdevices may be embedded within the cast polymer-based platform, or bonded to the platform structure subsequent to molding, to create an integrated microfluidic system. In this manner, the new microfluidic platform is versatile and capable of quickly generating prototype systems, and could easily be adapted to a manufacturing setting.

公开(公告)号：US20060029731A1

公开(公告)日：2006-02-09

申请号：US11243302

申请日：2005-10-03

申请人： James Davidson ,  Peter Krulevitch ,  Mariam Maghribi ,  William Benett ,  Julie Hamilton ,  Armando Tovar

发明人： James Davidson ,  Peter Krulevitch ,  Mariam Maghribi ,  William Benett ,  Julie Hamilton ,  Armando Tovar

IPC分类号： B05D3/12 ,  B05D5/00 ,  B05D1/02 ,  B05D3/02

CPC分类号： H01L23/145 ,  H01L23/5387 ,  H01L2924/0002 ,  H01L2924/1433 ,  H05K1/0272 ,  H05K1/0283 ,  H05K1/032 ,  H05K1/0393 ,  H05K1/095 ,  H05K3/101 ,  H05K3/12 ,  H05K3/1216 ,  H05K3/1258 ,  H05K3/1275 ,  H05K2201/0162 ,  H05K2203/0108 ,  H05K2203/0126 ,  H05K2203/082 ,  Y10S428/901 ,  Y10T428/24917 ,  H01L2924/00

摘要： A system of metalization in an integrated polymer microsystem. A flexible polymer substrate is provided and conductive ink is applied to the substrate. In one embodiment the flexible polymer substrate is silicone. In another embodiment the flexible polymer substrate comprises poly(dimethylsiloxane).

公开(公告)号：US20050030698A1

公开(公告)日：2005-02-10

申请号：US10939771

申请日：2004-09-13

申请人： Peter Krulevitch ,  Mariam Maghribi ,  William Benett ,  Julie Hamilton ,  Klint Rose ,  James Davidson ,  Mark Strauch

发明人： Peter Krulevitch ,  Mariam Maghribi ,  William Benett ,  Julie Hamilton ,  Klint Rose ,  James Davidson ,  Mark Strauch

IPC分类号： A61N1/04 ,  A61N1/05 ,  H01L23/538 ,  H01L25/065 ,  H05K1/00 ,  H05K1/03 ,  H01G4/30

CPC分类号： A61N1/0456 ,  A61B2560/0412 ,  A61N1/0452 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/05 ,  A61N1/0534 ,  H01L23/5387 ,  H01L25/065 ,  H01L2924/0002 ,  H01L2924/09701 ,  H05K1/0313 ,  H05K1/0393 ,  H05K2201/0162 ,  H05K2201/09118 ,  H01L2924/00

摘要： A peel and stick electronic system comprises a silicone body, and at least one electronic unit operatively connected to the silicone body. The electronic system is produce by providing a silicone layer on a substrate, providing a metal layer on the silicone layer, and providing at least one electronic unit connected to the metal layer.

摘要翻译： 剥离和粘贴电子系统包括硅树脂体和至少一个可操作地连接到硅氧烷体的电子单元。 该电子系统是通过在衬底上提供硅树脂层，在硅树脂层上提供金属层，并提供至少一个与金属层连接的电子单元来制造的。

公开(公告)号：US07025323B2

公开(公告)日：2006-04-11

申请号：US09957894

申请日：2001-09-21

申请人： Peter A. Krulevitch ,  William J. Benett ,  Klint A. Rose ,  Julie Hamilton ,  Mariam Maghribi

发明人： Peter A. Krulevitch ,  William J. Benett ,  Klint A. Rose ,  Julie Hamilton ,  Mariam Maghribi

IPC分类号： F16K31/124

CPC分类号： F16K99/0001 ,  F15C5/00 ,  F16K99/0011 ,  F16K99/0015 ,  F16K99/0044 ,  F16K99/0048 ,  F16K99/0059 ,  F16K99/0061 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/0084

摘要： Low power integrated pumping and valving arrays which provide a revolutionary approach for performing pumping and valving approach for performing pumping and valving operations in microfabricated fluidic systems for applications such as medical diagnostic microchips. Traditional methods rely on external, large pressure sources that defeat the advantages of miniaturization. Previously demonstrated microfabrication devices are power and voltage intensive, only function at sufficient pressure to be broadly applicable. This approach integrates a lower power, high-pressure source with a polymer, ceramic, or metal plug enclosed within a microchannel, analogous to a microsyringe. When the pressure source is activated, the polymer plug slides within the microchannel, pumping the fluid on the opposite side of the plug without allowing fluid to leak around the plug. The plugs also can serve as microvalves.

公开(公告)号：US20060052656A1

公开(公告)日：2006-03-09

申请号：US10938816

申请日：2004-09-09

申请人： Mariam Maghribi ,  Peter Krulevitch ,  James Davidson ,  Julie Hamilton

发明人： Mariam Maghribi ,  Peter Krulevitch ,  James Davidson ,  Julie Hamilton

IPC分类号： A61N2/00

CPC分类号： A61N1/0541 ,  A61N1/0543

摘要： A system for movement in a body and performing a function on the body. The system comprises a polymer body portion, an electronic unit carried by the polymer body portion, a circuit in the polymer body portion operatively connected to the electronic unit, pieces in the polymer body portion, and a system for controlling movement of the polymer body portion utilizing magnetic forces controlling movement of the pieces. The system utilizes magnetic guidance to control movement of a polymer body portion.

摘要翻译： 用于身体运动并在身体上执行功能的系统。 该系统包括聚合物主体部分，由聚合物主体部分承载的电子单元，可操作地连接到电子单元的聚合物主体部分中的电路，聚合物主体部分中的片，以及用于控制聚合物主体部分的运动的系统 利用磁力控制片的运动。 该系统利用磁引导来控制聚合物主体部分的运动。

公开(公告)号：US20070142878A1

公开(公告)日：2007-06-21

申请号：US11545190

申请日：2006-10-10

申请人： Peter Krulevitch ,  Dennis Polla ,  Mariam Maghribi ,  Julie Hamilton ,  Mark Humayun ,  James Weiland

发明人： Peter Krulevitch ,  Dennis Polla ,  Mariam Maghribi ,  Julie Hamilton ,  Mark Humayun ,  James Weiland

IPC分类号： A61N1/18

CPC分类号： A61N1/0543 ,  H05K1/118 ,  H05K3/205 ,  H05K3/4007 ,  H05K2201/0162 ,  H05K2201/09481 ,  H05K2203/0733 ,  Y10S623/90 ,  Y10S623/901 ,  Y10S623/905 ,  Y10S623/926 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49139 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49165 ,  Y10T29/49169 ,  Y10T29/49224

摘要： An image is captured or otherwise converted into a signal in an artificial vision system. The signal is transmitted to the retina utilizing an implant. The implant consists of a polymer substrate made of a compliant material such as poly(dimethylsiloxane) or PDMS. The polymer substrate is conformable to the shape of the retina. Electrodes and conductive leads are embedded in the polymer substrate. The conductive leads and the electrodes transmit the signal representing the image to the cells in the retina. The signal representing the image stimulates cells in the retina.

摘要翻译： 图像被捕获或以其他方式转换成人造视觉系统中的信号。 使用植入物将信号传输到视网膜。 植入物由由诸如聚（二甲基硅氧烷）或PDMS的柔顺材料制成的聚合物基材组成。 聚合物基材与视网膜的形状一致。 电极和导电引线嵌入在聚合物基底中。 导电引线和电极将表示图像的信号传输到视网膜中的细胞。 表示图像的信号刺激视网膜中的细胞。