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公开(公告)号:US07183302B2
公开(公告)日:2007-02-27
申请号:US10637099
申请日:2003-08-08
申请人: Jeffrey Lee Romine , Scott W. Martin , Lawrence B. Snyder , Michael Serrano-Wu , Milind Deshpande , Darren Whitehouse , Julie Lemm , Donald O'Boyle , Min Gao , Richard Colonno
发明人: Jeffrey Lee Romine , Scott W. Martin , Lawrence B. Snyder , Michael Serrano-Wu , Milind Deshpande , Darren Whitehouse , Julie Lemm , Donald O'Boyle , Min Gao , Richard Colonno
IPC分类号: A61K43/78 , C07D277/18
CPC分类号: C07D417/04 , A61K31/00 , A61K31/426 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K38/212 , A61K45/06 , C07D277/42 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , A61K2300/00
摘要: Compounds having the structure of formula I are described wherein R, R′, R1, R2, and R3 are as defined in the specification. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular the function of the HCV NS5A protein.
摘要翻译: 描述了具有式I结构的化合物,其中R 1,R 2,R 1,R 2和R 3均如 规范。 该化合物可以抑制丙型肝炎病毒(HCV)复制,特别是HCV NS5A蛋白的功能。
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公开(公告)号:US20110294819A1
公开(公告)日:2011-12-01
申请号:US12974069
申请日:2010-12-21
申请人: Omar D. Lopez , Denis R. St. Laurent , Jason Goodrich , Jeffrey Lee Romine , Michael Serrano-Wu , Fukang Yang , Ramesh Kakarla , Xuejie Yang , Yuping Qiu , Lawrence B. Snyder
发明人: Omar D. Lopez , Denis R. St. Laurent , Jason Goodrich , Jeffrey Lee Romine , Michael Serrano-Wu , Fukang Yang , Ramesh Kakarla , Xuejie Yang , Yuping Qiu , Lawrence B. Snyder
IPC分类号: A61K31/421 , C07D413/14 , C07D471/04 , C07D403/14 , C07D417/14 , C07D401/14 , C07D231/12 , C07D249/08 , C07D249/12 , C07D249/06 , C07D409/14 , C07D405/14 , A61K31/422 , A61K31/496 , A61K31/427 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/4178 , A61K31/4725 , A61P31/14 , C07D263/32
CPC分类号: A61K31/415 , A61K31/4196 , A61K31/4245 , C07D231/12 , C07D233/58 , C07D233/64 , C07D249/06 , C07D249/08 , C07D249/12 , C07D263/32 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要: The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein.
摘要翻译: 本公开一般涉及抗病毒化合物,更具体地涉及可以抑制由丙型肝炎病毒(HCV)编码的NS5A蛋白的功能的化合物,包含这些化合物的组合物,以及用于抑制NS5A蛋白功能的方法。
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公开(公告)号:US20100068176A1
公开(公告)日:2010-03-18
申请号:US12536362
申请日:2009-08-05
申请人: Makonen Belema , Andrew C. Good , Jason Goodrich , Ramesh Kakarla , Guo Li , Omar D. Lopez , Van N. Nguyen , Jayne Kapur , Yuping Qiu , Jeffrey Lee Romine , Denis R. St. Laurent , Michael Serrano-Wu , Lawrence B. Snyder , Fukang Yang
发明人: Makonen Belema , Andrew C. Good , Jason Goodrich , Ramesh Kakarla , Guo Li , Omar D. Lopez , Van N. Nguyen , Jayne Kapur , Yuping Qiu , Jeffrey Lee Romine , Denis R. St. Laurent , Michael Serrano-Wu , Lawrence B. Snyder , Fukang Yang
IPC分类号: A61K38/20 , C07D403/14 , A61K31/4184 , A61K31/497 , A61K38/21 , A61K31/7088 , A61P31/12
CPC分类号: C07D235/20 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译: 本公开涉及用于治疗丙型肝炎病毒(HCV)感染的化合物,组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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公开(公告)号:US07906655B2
公开(公告)日:2011-03-15
申请号:US12536362
申请日:2009-08-05
申请人: Makonen Belema , Andrew C. Good , Jason Goodrich , Ramesh Kakarla , Guo Li , Omar D. Lopez , Van N. Nguyen , Jayne Kapur , Yuping Qiu , Jeffrey Lee Romine , Denis R. St. Laurent , Michael Serrano-Wu , Lawrence B. Snyder , Fukang Yang
发明人: Makonen Belema , Andrew C. Good , Jason Goodrich , Ramesh Kakarla , Guo Li , Omar D. Lopez , Van N. Nguyen , Jayne Kapur , Yuping Qiu , Jeffrey Lee Romine , Denis R. St. Laurent , Michael Serrano-Wu , Lawrence B. Snyder , Fukang Yang
IPC分类号: C07D403/14 , C07D217/08 , C07D211/32 , C07D239/04 , C07D413/14 , A61K31/47 , A61K31/497 , A61K31/445 , A61K31/5355 , A01N43/60
CPC分类号: C07D235/20 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译: 本公开涉及用于治疗丙型肝炎病毒(HCV)感染的化合物,组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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公开(公告)号:US08362020B2
公开(公告)日:2013-01-29
申请号:US12974069
申请日:2010-12-21
申请人: Omar D. Lopez , Denis R. St. Laurent , Jason Goodrich , Jeffrey Lee Romine , Michael Serrano-Wu , Fukang Yang , Ramesh Kakarla , Xuejie Yang , Yuping Qiu , Lawrence B. Snyder
发明人: Omar D. Lopez , Denis R. St. Laurent , Jason Goodrich , Jeffrey Lee Romine , Michael Serrano-Wu , Fukang Yang , Ramesh Kakarla , Xuejie Yang , Yuping Qiu , Lawrence B. Snyder
IPC分类号: A61K31/422 , A61K31/4025 , A61K31/496 , A61K31/427 , A61K31/438 , A61K31/444 , A61K31/4545 , C07D263/32 , C07D207/09 , C07D413/14 , C07D471/04 , C07D417/14
CPC分类号: A61K31/415 , A61K31/4196 , A61K31/4245 , C07D231/12 , C07D233/58 , C07D233/64 , C07D249/06 , C07D249/08 , C07D249/12 , C07D263/32 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要: The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein.
摘要翻译: 本公开一般涉及抗病毒化合物,更具体地涉及可以抑制由丙型肝炎病毒(HCV)编码的NS5A蛋白的功能的化合物,包含这些化合物的组合物,以及用于抑制NS5A蛋白功能的方法。
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公开(公告)号:US20110077280A1
公开(公告)日:2011-03-31
申请号:US12729940
申请日:2010-03-23
申请人: John A. Bender , Piyasena Hewawasam , John F. Kadow , Omar D. Lopez , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Lawrence B. Snyder , Denis R. St. Laurent , Gan Wang , Ningning Xu , Makonen Belema
发明人: John A. Bender , Piyasena Hewawasam , John F. Kadow , Omar D. Lopez , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Lawrence B. Snyder , Denis R. St. Laurent , Gan Wang , Ningning Xu , Makonen Belema
IPC分类号: A61K31/4178 , C07D403/14 , A61K31/4184 , C07D405/14 , A61P31/14
CPC分类号: C07D403/04 , C07D403/14 , C07D405/14
摘要: This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.
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公开(公告)号:US20080299075A1
公开(公告)日:2008-12-04
申请号:US12029680
申请日:2008-02-12
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号: C07D403/14 , A61K31/4178 , A61K38/20 , A61K38/21 , A61K38/43 , A61K38/48 , A61K31/7088 , A61K38/16 , A61P31/12
CPC分类号: C07D403/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译: 本公开涉及用于治疗丙型肝炎病毒(HCV)感染的化合物,组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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公开(公告)号:US20080044379A1
公开(公告)日:2008-02-21
申请号:US11835485
申请日:2007-08-08
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号: A61K38/20 , A61K31/4178 , A61K31/4196 , A61K31/4245 , A61K31/426 , A61K31/4353 , A61K31/4427 , A61K38/21 , C07D213/02 , C07D295/00 , C07D277/02 , C07D249/08 , C07D241/02 , C07D239/02 , C07D237/02 , C07D233/54 , C07D221/00 , A61P31/12 , A61K31/4523 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/7052
CPC分类号: C07D401/14 , C07D403/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US20130004457A1
公开(公告)日:2013-01-03
申请号:US13609957
申请日:2012-09-11
申请人: Carol Bachand , Makonen Bekema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Bekema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号: C07D403/14 , A61K31/506 , C07D417/14 , A61K31/427 , C07D405/14 , A61P31/16 , A61K31/4545 , A61K38/21 , A61K31/7056 , A61K38/20 , A61K31/7105 , A61K31/4745 , A61K31/4178 , C07D401/14
CPC分类号: A61K31/506 , A61K31/13 , A61K31/4178 , A61K31/427 , A61K31/4745 , A61K31/7056 , A61K31/7105 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K38/212 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US20120328570A1
公开(公告)日:2012-12-27
申请号:US13606231
申请日:2012-09-07
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号: A61K31/4178 , C07D401/14 , A61K31/4545 , C07D413/14 , A61K31/5377 , A61P31/14 , A61K31/695 , A61K38/21 , A61K31/7056 , A61K38/20 , A61K31/713 , C07D403/14 , C07F7/10
CPC分类号: C07D403/14 , A61K31/4178 , A61K31/4545 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07F7/10
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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