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公开(公告)号:US07884098B2
公开(公告)日:2011-02-08
申请号:US12524009
申请日:2008-01-25
申请人: Jeffrey Michael Axten , Deborah L. Bryan , David Harold Drewry , Thomas H Faitg , Timothy Francis Gallagher , Neil W Johnson , Jiri Kasparec , Jeffrey M Ralph , Domingos J. Silva
发明人: Jeffrey Michael Axten , Deborah L. Bryan , David Harold Drewry , Thomas H Faitg , Timothy Francis Gallagher , Neil W Johnson , Jiri Kasparec , Jeffrey M Ralph , Domingos J. Silva
IPC分类号: A61K31/5355 , A61K31/541 , A61K31/505 , A61K31/506 , C07D279/12 , C07D403/02 , C07D239/24 , C07D413/02
CPC分类号: C07D403/12 , C07D241/20 , C07D413/12
摘要: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1′ R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
摘要翻译: 本发明涉及由下式表示的化合物或其药学上可接受的盐; 其中R1,R1'R2,R3,R4,R5,r和s如本文所定义。 本发明的化合物可用于治疗与极光激酶活性相关的疾病如癌症。
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公开(公告)号:US20100016318A1
公开(公告)日:2010-01-21
申请号:US12524009
申请日:2008-01-25
申请人: Jeffrey Michael Axten , Deborah L. Bryan , David Harold Drewry , Thomas H. Faitg , Timothy Francis Gallagher , Neil W. Johnson , Jiri Kasparec , Jeffrey M. Ralph , Domingos J. Silva
发明人: Jeffrey Michael Axten , Deborah L. Bryan , David Harold Drewry , Thomas H. Faitg , Timothy Francis Gallagher , Neil W. Johnson , Jiri Kasparec , Jeffrey M. Ralph , Domingos J. Silva
IPC分类号: A61K31/5355 , A61K31/541 , A61K31/505 , A61K31/506 , C07D279/12 , C07D403/02 , C07D239/24 , C07D413/02
CPC分类号: C07D403/12 , C07D241/20 , C07D413/12
摘要: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1′ R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
摘要翻译: 本发明涉及由下式表示的化合物或其药学上可接受的盐; 其中R1,R1'R2,R3,R4,R5,r和s如本文所定义。 本发明的化合物可用于治疗与极光激酶活性相关的疾病如癌症。
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公开(公告)号:US07625903B2
公开(公告)日:2009-12-01
申请号:US12019730
申请日:2008-01-25
申请人: Neil W. Johnson , Deborah L. Bryan
发明人: Neil W. Johnson , Deborah L. Bryan
IPC分类号: A61K31/497 , C07D403/00
CPC分类号: C07D403/12 , C07D241/20 , C07D413/12
摘要: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; where R1, R2, R3, R4, r and s are as previously defined. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
摘要翻译: 本发明涉及由下式表示的化合物或其药学上可接受的盐; 其中R1,R2,R3,R4,r和s如前所定义。 本发明的化合物可用于治疗与极光激酶活性相关的疾病如癌症。
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公开(公告)号:US20080182852A1
公开(公告)日:2008-07-31
申请号:US12019730
申请日:2008-01-25
申请人: Neil W. Johnson , Deborah L. Bryan
发明人: Neil W. Johnson , Deborah L. Bryan
IPC分类号: A61K31/496 , C07D241/04 , A61P35/00
CPC分类号: C07D403/12 , C07D241/20 , C07D413/12
摘要: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; where R1, R2, R3, R4, r and s are as previously defined. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
摘要翻译: 本发明涉及由下式表示的化合物或其药学上可接受的盐; 其中R 1,R 2,R 3,R 4,R 4和s如前所定义。 本发明的化合物可用于治疗与极光激酶活性相关的疾病如癌症。
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公开(公告)号:US4352757A
公开(公告)日:1982-10-05
申请号:US230915
申请日:1981-02-02
IPC分类号: C07C17/16 , C07C29/17 , C07C29/32 , C07C33/02 , C07C33/04 , C07D303/40 , C07D303/42 , C07F9/54
CPC分类号: C07F9/5428 , C07C17/16 , C07C29/17 , C07C29/32 , C07C33/02 , C07C33/04 , C07D303/40 , C07D303/42
摘要: Esters of leukotriene A are conveniently prepared by reacting 9-oxo-5,6-trans-epoxynon-7(E)-enoates with 11-triphenylphosphoranylidene undec-6(Z),9(Z)-diene. Esters of leukotriene-A are useful intermediates in the synthesis of naturally occurring leukotrienes, which have been shown to be potent broncho-constricting substances. Novel intermediates to the esters of leukotriene A, 9-oxo-5,6-transepoxynon-7(E)-enoates and 7-oxo-5,6-transepoxyheptanoates, are disclosed.
摘要翻译: 通过9-氧代-5,6-反式环氧壬基-7(E) - 烯酸酯与11-三苯基亚正膦基十一碳烯-6(Z),9(Z) - 二烯反应,方便地制备白三烯A的酯。 白三烯-A的酯类是天然存在的白三烯合成中的有用中间体,已被证明是有效的支气管收缩物质。 公开了白三烯A,9-氧代-5,6-脱氧壬基-7(E) - 烯酸酯和7-氧代-5,6-异丙氧基庚酸酯的新型中间体。
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公开(公告)号:US07449484B2
公开(公告)日:2008-11-11
申请号:US11388058
申请日:2006-03-23
申请人: Jerry L. Adams , Deborah L. Bryan
发明人: Jerry L. Adams , Deborah L. Bryan
IPC分类号: A61K31/4439 , C07D401/04
CPC分类号: C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14
摘要: The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred.
摘要翻译: 本发明涉及用于治疗哺乳动物疾病的新颖的式(I)化合物,其中发生不适当,过量或不期望的血管发生和/或已经发生过度的Tie2受体活性。
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公开(公告)号:US5559105A
公开(公告)日:1996-09-24
申请号:US374544
申请日:1995-01-17
申请人: Deborah L. Bryan , John D. Elliott
发明人: Deborah L. Bryan , John D. Elliott
IPC分类号: C07D317/60 , C07D405/06 , C07F7/08 , C07F9/655 , A61K31/41 , C07D403/02
CPC分类号: C07D405/06 , C07D317/60 , C07F7/0812 , C07F9/65517
摘要: A compound of formula: ##STR1##
摘要翻译: PCT No.PCT / US93 / 06667 Sec。 371日期1995年1月17日 102(e)日期1995年1月17日PCT提交1993年7月15日PCT公布。 公开号WO94 / 02474 日期1994年2月3日具有下列化学式的化合物:(1)
(a) (b) -
公开(公告)号:US4387239A
公开(公告)日:1983-06-07
申请号:US333850
申请日:1981-12-22
IPC分类号: C07C17/16 , C07C29/17 , C07C29/32 , C07C33/02 , C07C33/04 , C07D303/40 , C07D303/42 , C07F9/54
CPC分类号: C07F9/5428 , C07C17/16 , C07C29/17 , C07C29/32 , C07C33/02 , C07C33/04 , C07D303/40 , C07D303/42 , C07B2200/09
摘要: Esters of leukotriene A are conveniently prepared by reacting 9-oxo-5,6-trans-epoxynon-7(E)-enoates with 11-triphenylphosphoranylidene undec-6(Z),9(Z)-diene. Esters of leukotriene-A are useful intermediates in the synthesis of naturally occurring leukotrienes, which have been shown to be potent broncho-constricting substances. Novel intermediates to the esters of leukotriene A. 9-oxo-5,6-trans-epoxynon-7(E)-enoates and 7-oxo-5,6-trans-epoxyheptanoates, are disclosed.
摘要翻译: 通过9-氧代-5,6-反式环氧壬基-7(E) - 烯酸酯与11-三苯基亚正膦基十一碳烯-6(Z),9(Z) - 二烯反应,方便地制备白三烯A的酯。 白三烯-A的酯类是天然存在的白三烯合成中的有用中间体,已被证明是有效的支气管收缩物质。 公开了白三烯A 9-氧代-5,6-反式环氧壬烷-7(E) - 烯酸酯和7-氧代-5,6-反式 - 环氧庚酸酯的新型中间体。
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公开(公告)号:US07087758B2
公开(公告)日:2006-08-08
申请号:US10474084
申请日:2002-04-04
IPC分类号: A61K31/47 , C07D215/38 , C07D215/12
CPC分类号: C07D401/12 , A61K31/47 , A61K31/4709 , C07D215/54
摘要: This invention relates to novel quinoline inhibitors of hYAK1 and hYAK3 kinases and pharmaceutically acceptable salts, hydrates or solvates thereof, pharmaceutical compositions thereof, and methods of treatment of diseases in which an excessive amount of either such kinase is a factor.
摘要翻译: 本发明涉及hYAK1和hYAK3激酶的新型喹啉抑制剂及其药学上可接受的盐,水合物或溶剂化物,其药物组合物和治疗其中过量的这种激酶是因子的疾病的方法。
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公开(公告)号:US4440939A
公开(公告)日:1984-04-03
申请号:US439088
申请日:1982-11-04
IPC分类号: C07C17/16 , C07C29/17 , C07C29/32 , C07C33/02 , C07C33/04 , C07D303/40 , C07D303/42 , C07F9/54
CPC分类号: C07F9/5428 , C07C17/16 , C07C29/17 , C07C29/32 , C07C33/02 , C07C33/04 , C07D303/40 , C07D303/42 , C07B2200/09
摘要: Esters of leukotriene A are conveniently prepared by reacting 9-oxo-5,6-trans-epoxynon-7(E)-enoates with 11-triphenylphosphoranylidene undec-6(Z),9(Z)-diene. Esters of leukotriene-A are useful intermediates in the synthesis of naturally occurring leukotrienes, which have been shown to be potent broncho-constricting substances. Novel intermediates to the esters of leukotriene A, 9-oxo-5,6-transepoxynon-7(E)-enoates and 7-oxo-5,6-trans-epoxyheptanoates, are disclosed.
摘要翻译: 通过9-氧代-5,6-反式环氧壬基-7(E) - 烯酸酯与11-三苯基亚正膦基十一碳烯-6(Z),9(Z) - 二烯反应,方便地制备白三烯A的酯。 白三烯-A的酯类是天然存在的白三烯合成中的有用中间体,已被证明是有效的支气管收缩物质。 公开了白三烯A,9-氧代-5,6-过氧壬烯-7(E) - 烯酸酯和7-氧代-5,6-反式 - 环氧庚酸酯的新型中间体。
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