-
公开(公告)号:US20150126490A1
公开(公告)日:2015-05-07
申请号:US14527328
申请日:2014-10-29
申请人: Jeffrey T. BAGDANOFF , Yu DING , Wooseok HAN , Zilin HUANG , Qun JIANG , Jeff Xianming JIN , Xiang KOU , Patrick LEE , Mika LINDVALL , Zhongcheng MIN , Yue PAN , Sabina PECCHI , Keith Bruce PFISTER , Daniel POON , Vivek RAUNIYAR , Xiaojing Michael WANG , Qiong ZHANG , Jianguang ZHOU , Shejin ZHU
发明人: Jeffrey T. BAGDANOFF , Yu DING , Wooseok HAN , Zilin HUANG , Qun JIANG , Jeff Xianming JIN , Xiang KOU , Patrick LEE , Mika LINDVALL , Zhongcheng MIN , Yue PAN , Sabina PECCHI , Keith Bruce PFISTER , Daniel POON , Vivek RAUNIYAR , Xiaojing Michael WANG , Qiong ZHANG , Jianguang ZHOU , Shejin ZHU
IPC分类号: C07D498/04 , A61K31/497 , A61K45/06 , C07D401/04 , A61K31/4545 , C07D405/14 , A61K31/506 , C07D409/04 , A61K31/4436 , A61K31/5383 , C07D241/20 , A61K31/4965 , A61K31/4439 , C07D413/14 , A61K31/5377 , A61K31/553 , C07D405/04
CPC分类号: A61K31/497 , A61K31/44 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4965 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , A61K2121/00 , C07D213/73 , C07D241/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D498/04
摘要: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
摘要翻译: 本发明提供式(I)的化合物或其盐; 和这些化合物的治疗用途。 本发明还提供包含这些化合物的药物组合物,以及包含这些化合物与治疗性助剂的组合物。
-
公开(公告)号:US20170182038A1
公开(公告)日:2017-06-29
申请号:US14964057
申请日:2015-12-09
申请人: Jeffrey T. BAGDANOFF , Yu DING , Wooseok HAN , Zilin HUANG , Qun JIANG , Xianming JIN , Xiang KOU , Patrick LEE , Mika LINDVALL , Zhongcheng MIN , Yue PAN , Sabina PECCHI , Keith Bruce PFISTER , Daniel POON , Vivek RAUNIYAR , Xiaojing Michael WANG , Qiong ZHANG , Jianguang ZHOU , Shejin ZHU
发明人: Jeffrey T. BAGDANOFF , Yu DING , Wooseok HAN , Zilin HUANG , Qun JIANG , Xianming JIN , Xiang KOU , Patrick LEE , Mika LINDVALL , Zhongcheng MIN , Yue PAN , Sabina PECCHI , Keith Bruce PFISTER , Daniel POON , Vivek RAUNIYAR , Xiaojing Michael WANG , Qiong ZHANG , Jianguang ZHOU , Shejin ZHU
IPC分类号: A61K31/497 , A61K31/5355 , A61K31/4436 , A61K31/4433 , A61K31/44
CPC分类号: A61K31/497 , A61K31/44 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4965 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , A61K2121/00 , C07D213/73 , C07D241/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D498/04
摘要: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
-
公开(公告)号:US20110256128A1
公开(公告)日:2011-10-20
申请号:US13085746
申请日:2011-04-13
申请人: Tinya ABRAMS , Paul A. BARSANTI , Yu DING , David DUHL , Wooseok HAN , Cheng HU , Yue PAN
发明人: Tinya ABRAMS , Paul A. BARSANTI , Yu DING , David DUHL , Wooseok HAN , Cheng HU , Yue PAN
IPC分类号: A61K31/4196 , C07D413/12 , A61K31/5377 , A61P35/02 , A61K33/24 , A61K31/7068 , A61P35/00 , A61K31/661 , C07D407/12 , A61K39/395
CPC分类号: C07D403/12 , A61K31/4196 , A61K31/5377 , A61K45/06 , C07D207/10 , C07D249/08 , C07D405/12 , C07D405/14 , C07D413/14
摘要: The present invention provides triazole compounds of Formula I: as further described herein. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I, and a method of treating a disorder mediated, at least in part, by KSP in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of a compound of Formula I.
摘要翻译: 本发明提供式I的三唑化合物:如本文进一步描述的。 本发明还提供了包含治疗有效量的式I化合物的药物组合物,以及治疗在哺乳动物患者中至少部分地由KSP介导的病症的方法,包括向需要这种治疗的哺乳动物患者施用 治疗有效量的式I化合物。
-
公开(公告)号:US20160038504A1
公开(公告)日:2016-02-11
申请号:US14774431
申请日:2014-03-13
申请人: Robert AVERSA , Paul A. BARSANTI , Matthew BURGER , Michael Patrick DILLON , Alan DIPESA , Cheng HU , Yan LOU , Gisele NISHIGUCHI , Yue PAN , Valery POLYAKOV , Savithri RAMURTHY , Alice RICO , Lina SETTI , Aaron SMITH , Sharadha SUBRAMANIAN , Benjamin TAFT , Huw TANNER , Lifeng WAN , Naeem YUSUFF
发明人: Robert John AVERSA , Paul Andrew BARSANTI , Matthew T. BURGER , Michael Patrick DILLON , Alan DIPESA , Cheng HU , Yan LOU , Gisele A. NISHIGUCHI , Yue PAN , Valery Rostislavovich POLYAKOV , Savithri RAMURTHY , Alice C. RICO , Lina Quattrocchio SETTI , Aaron SMITH , Sharadha SUBRAMANIAN , Benjamin R. TAFT , Huw Roland TANNER , Lifeng WAN , Naeem YUSUFF
IPC分类号: A61K31/5377 , C07D401/12 , C07D413/04 , C07D413/14 , C07D239/48 , A61K31/541 , C07D401/04 , C07D413/12 , C07D417/12 , C07D239/47 , C07D491/107 , C07D403/04 , C07D498/08 , A61K31/5375 , C07D237/20 , C07D213/74 , C07D405/14 , C07D405/04 , C07D241/20 , C07D405/12 , C07D237/22 , C07D213/84 , C07D213/82 , C07D487/04 , C07D471/04 , C07D495/04 , C07D491/048 , C07D513/04 , C07D409/14 , C07D213/81 , C07D263/58 , C07D239/42
CPC分类号: A61K31/5377 , A61K31/444 , A61K31/501 , A61K31/5375 , A61K31/541 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/84 , C07D233/88 , C07D237/20 , C07D237/22 , C07D237/24 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D263/58 , C07D277/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D491/08 , C07D491/107 , C07D493/04 , C07D493/10 , C07D495/04 , C07D498/08 , C07D513/04
摘要: The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.
摘要翻译: 本发明提供了本文所述的式(I)化合物及其盐,以及这些化合物治疗与Raf激酶活性相关的疾病的治疗用途。 本发明还提供包含这些化合物的药物组合物,以及包含这些化合物和治疗性助剂的组合物。
-
-
-