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1.N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions 有权
标题翻译: 可用于治疗血栓形成条件的P2Y1受体的N-连接杂环拮抗剂公开(公告)号:US20060293281A1
公开(公告)日:2006-12-28
申请号:US11474888
申请日:2006-06-26
申请人: Jennifer Qiao , Tammy Wang , James Sutton , Timur Gungor
发明人: Jennifer Qiao , Tammy Wang , James Sutton , Timur Gungor
IPC分类号: A61K31/695 , C07F7/02 , A61K31/554 , A61K31/551 , A61K31/538 , C07D417/02 , C07D403/02 , C07D413/02 , A61K31/4439 , A61K31/5415 , A61K31/5513 , A61K31/553
CPC分类号: C07D471/10 , C07D401/04 , C07D401/12 , C07D417/12 , C07D417/14
摘要: The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, D and W are as defined herein. These compounds are selective inhibitors of the human P2Y1 receptor which can be used as medicaments.
摘要翻译: 本发明提供了包含式(I)的N-芳基或N-杂芳基取代的杂环的新型脲:或其立体异构体,互变异构体,药学上可接受的盐或溶剂化物形式,其中变量A,B,D和W如本文所定义 。 这些化合物是可用作药物的人P2Y 1受体的选择性抑制剂。
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2.LACTAM CONTAINING CYCLIC DIAMINES AND DERIVATIVES AS FACTOR XA INHIBITORS 审中-公开
标题翻译: 含有循环二氨基甲酸酯和衍生物的LACTAM作为因子XA抑制剂公开(公告)号:US20070135428A1
公开(公告)日:2007-06-14
申请号:US11675786
申请日:2007-02-16
申请人: Jennifer Qiao , Tammy Wang , Gren Wang , Timur Gungor
发明人: Jennifer Qiao , Tammy Wang , Gren Wang , Timur Gungor
IPC分类号: A61K31/538 , A61K31/501 , A61K31/517 , A61K31/496
CPC分类号: C07D213/64 , C07D213/75 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要: The present application describes lactam-containing cyclic diamines and derivatives thereof of Formula I: P4-M-M4 I or pharmaceutically acceptable salt forms thereof, wherein M is a non-aromatic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
摘要翻译: 本申请描述了含有内酰胺的环状二胺及其式I的衍生物:<?in-line-formula description =“In-line Formulas”end =“lead”?> P u> 其中M是非芳族碳环或杂环,其中M是非芳族碳环或杂环。 本发明的化合物可用作胰蛋白酶样丝氨酸蛋白酶的抑制剂,特别是因子Xa。
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3.Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions 有权
标题翻译: P2Y1受体的尿素拮抗剂可用于治疗血栓形成公开(公告)号:US20050267119A1
公开(公告)日:2005-12-01
申请号:US11126915
申请日:2005-05-11
申请人: Hannguang Chao , Huji Tuerdi , Timothy Herpin , Jacques Roberge , Yalei Liu , R. Lawrence , Robert Rehfuss , Charles Clark , Jennifer Qiao , Timur Gungor , Patrick Lam , Tammy Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora Schnur
发明人: Hannguang Chao , Huji Tuerdi , Timothy Herpin , Jacques Roberge , Yalei Liu , R. Lawrence , Robert Rehfuss , Charles Clark , Jennifer Qiao , Timur Gungor , Patrick Lam , Tammy Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora Schnur
IPC分类号: A61K31/4439 , A61K31/444 , A61K31/501 , C07C275/30 , C07C275/32 , C07D213/40 , C07D213/75 , C07D213/89 , C07D231/40 , C07D231/50 , C07D237/22 , C07D333/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07F7/18 , C07D43/02 , C07D41/02
CPC分类号: C07D409/14 , C07C275/30 , C07C275/32 , C07D213/40 , C07D213/75 , C07D213/89 , C07D231/40 , C07D231/50 , C07D237/22 , C07D333/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07F7/1804
摘要: The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译: 本发明提供了新的吡啶基或苯基脲及其类似物,它们是人P2Y 1受体的选择性抑制剂。 本发明还提供了相同的各种药物组合物以及治疗对P2Y受体活性的调节作用的疾病的方法。
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4.Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions 有权
标题翻译: P2Y1受体的尿素拮抗剂可用于治疗血栓形成公开(公告)号:US20050261244A1
公开(公告)日:2005-11-24
申请号:US11126567
申请日:2005-05-10
申请人: Huji Tuerdi , Hannguang Chao , Jennifer Qiao , Tammy Wang , Timur Gungor
发明人: Huji Tuerdi , Hannguang Chao , Jennifer Qiao , Tammy Wang , Timur Gungor
IPC分类号: A61K31/444 , A61K31/497 , A61K31/498 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K31/695 , A61P7/02 , C07D209/08 , C07D209/14 , C07D209/96 , C07D215/06 , C07D241/42 , C07D401/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04 , C07D413/02 , C07D417/02 , C07D471/10 , C07D43/02
CPC分类号: C07D409/04 , C07D209/08 , C07D209/14 , C07D209/96 , C07D215/06 , C07D241/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D471/10
摘要: The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译: 本发明提供了含有N-芳基或N-杂芳基取代的杂环及其类似物的新型脲,它们是人P2Y 1受体的选择性抑制剂。 本发明还提供了相同的各种药物组合物以及治疗对P2Y受体活性的调节作用的疾病的方法。
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5.N-LINKED HETEROCYCLIC ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS 有权
标题翻译: P2Y1受体的N-连锁杂交拮抗剂用于治疗血栓病症公开(公告)号:US20100197716A1
公开(公告)日:2010-08-05
申请号:US12761447
申请日:2010-04-16
申请人: Jennifer Qiao , Tammy C. Wang , James C. Sutton , Timur Gungor
发明人: Jennifer Qiao , Tammy C. Wang , James C. Sutton , Timur Gungor
IPC分类号: A61K31/438 , C07D417/12 , A61K31/4709 , A61P7/02 , A61P9/10 , C07D401/04 , A61K31/4439 , C07D471/10 , A61K31/428
CPC分类号: C07D471/10 , C07D401/04 , C07D401/12 , C07D417/12 , C07D417/14
摘要: The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, D and W are as defined herein. These compounds are selective inhibitors of the human P2Y1 receptor which can be used as medicaments.
摘要翻译: 本发明提供了包含式(I)的N-芳基或N-杂芳基取代的杂环的新型脲:或其立体异构体,互变异构体,药学上可接受的盐或溶剂化物形式,其中变量A,B,D和W如本文所定义 。 这些化合物是可用作药物的人P2Y1受体的选择性抑制剂。
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6.N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions 有权
标题翻译: 可用于治疗血栓形成条件的P2Y1受体的N-连接杂环拮抗剂公开(公告)号:US07728008B2
公开(公告)日:2010-06-01
申请号:US11474888
申请日:2006-06-26
申请人: Jennifer Qiao , Tammy C. Wang , James C. Sutton , Timur Gungor
发明人: Jennifer Qiao , Tammy C. Wang , James C. Sutton , Timur Gungor
IPC分类号: A61K31/435
CPC分类号: C07D471/10 , C07D401/04 , C07D401/12 , C07D417/12 , C07D417/14
摘要: The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, D and W are as defined herein. These compounds are selective inhibitors of the human P2Y1 receptor which can be used as medicaments.
摘要翻译: 本发明提供了包含式(I)的N-芳基或N-杂芳基取代的杂环的新型脲:或其立体异构体,互变异构体,药学上可接受的盐或溶剂化物形式,其中变量A,B,D和W如本文所定义 。 这些化合物是可用作药物的人P2Y1受体的选择性抑制剂。
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公开(公告)号:US20070161685A1
公开(公告)日:2007-07-12
申请号:US11559930
申请日:2006-11-15
申请人: Mark Salvati , Heather Finlay , Lalgudi Harikrishnan , Ji Jiang , James Johnson , Muthoni Kamau , R. Lawrence , Michael Miller , Jennifer Qiao , Tammy Wang , Yufeng Wang , Wu Yang
发明人: Mark Salvati , Heather Finlay , Lalgudi Harikrishnan , Ji Jiang , James Johnson , Muthoni Kamau , R. Lawrence , Michael Miller , Jennifer Qiao , Tammy Wang , Yufeng Wang , Wu Yang
IPC分类号: A61K31/44 , C07D213/56
CPC分类号: C07D417/06 , C07D213/40 , C07D213/61 , C07D277/28 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D417/12
摘要: Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.
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公开(公告)号:US20070135631A1
公开(公告)日:2007-06-14
申请号:US11558979
申请日:2006-11-13
申请人: Mark Salvati , Heather Finlay , Bang-Chi Chen , Lalgudi Harikrishnan , Ji Jiang , James Johnson , Muthoni Kamau , R. Lawrence , Jianqing Li , John Lloyd , Michael Miller , Zulan Pi , Jennifer Qiao , Richard Rampulla , Jacques Roberge , Tammy Wang , Yufeng Wang , Wu Yang
发明人: Mark Salvati , Heather Finlay , Bang-Chi Chen , Lalgudi Harikrishnan , Ji Jiang , James Johnson , Muthoni Kamau , R. Lawrence , Jianqing Li , John Lloyd , Michael Miller , Zulan Pi , Jennifer Qiao , Richard Rampulla , Jacques Roberge , Tammy Wang , Yufeng Wang , Wu Yang
IPC分类号: C07D257/02 , C07C237/38
CPC分类号: C07C275/26 , C07C211/29 , C07C215/08 , C07C217/58 , C07C229/36 , C07C229/38 , C07C233/09 , C07C233/13 , C07C233/18 , C07C233/56 , C07C233/60 , C07C233/66 , C07C233/73 , C07C233/78 , C07C235/20 , C07C235/34 , C07C235/48 , C07C235/74 , C07C237/06 , C07C237/08 , C07C251/38 , C07C255/13 , C07C255/57 , C07C255/60 , C07C271/16 , C07C271/20 , C07C271/44 , C07C275/24 , C07C311/04 , C07C311/17 , C07C317/44 , C07C323/57 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/08 , C07D207/10 , C07D207/16 , C07D207/26 , C07D207/273 , C07D207/325 , C07D207/38 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/48 , C07D211/38 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/82 , C07D231/14 , C07D231/40 , C07D239/26 , C07D249/04 , C07D249/06 , C07D249/08 , C07D249/14 , C07D257/04 , C07D257/06 , C07D261/04 , C07D261/08 , C07D261/14 , C07D261/18 , C07D263/34 , C07D271/06 , C07D271/10 , C07D271/113 , C07D277/48 , C07D277/58 , C07D277/60 , C07D285/06 , C07D285/135 , C07D295/155 , C07D303/48 , C07D307/22 , C07D307/24 , C07D307/33 , C07D307/68 , C07D307/79 , C07D307/85 , C07D311/58 , C07D317/46 , C07D319/20 , C07D333/20 , C07D333/24 , C07D333/38 , C07D333/68 , C07D333/70 , C07D471/04 , C07F7/081
摘要: Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.
摘要翻译: 其中A,B,C和R 1'的式Ia和Ib化合物在本文中描述。
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9.C-linked cyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions 有权
标题翻译: P2Y1受体的C连接环状拮抗剂可用于治疗血栓形成公开(公告)号:US20060293336A1
公开(公告)日:2006-12-28
申请号:US11474899
申请日:2006-06-26
申请人: James Sutton , Jennifer Qiao , Carl Thibeault , Rejean Ruel
发明人: James Sutton , Jennifer Qiao , Carl Thibeault , Rejean Ruel
IPC分类号: A61K31/501 , A61K31/4439 , A61K31/427 , A61K31/423 , C07D417/02 , C07D413/02 , C07D403/02 , A61K31/4188
CPC分类号: C07D209/14 , C07C275/34 , C07C275/42 , C07C323/44 , C07C2601/02 , C07C2601/14 , C07D213/40 , C07D213/61 , C07D213/64 , C07D213/75 , C07D215/12 , C07D235/14 , C07D235/18 , C07D307/81 , C07D307/87 , C07D317/58 , C07D333/58 , C07D401/04 , C07D405/04 , C07D409/04 , C07D417/12
摘要: The present invention provides novel C-linked cyclic compounds and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, D and W are as defined herein. These compounds are selective inhibitors of the human P2Y1 receptor which can be used as medicaments.
摘要翻译: 本发明提供新的C连接的环状化合物和式(I)的类似物:或其立体异构体,互变异构体,药学上可接受的盐或溶剂化物形式,其中变量A,B,D和W如本文所定义。 这些化合物是可用作药物的人P2Y 1受体的选择性抑制剂。
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公开(公告)号:US07115627B2
公开(公告)日:2006-10-03
申请号:US10304070
申请日:2002-11-25
申请人: Donald J. P. Pinto , Wei Han , Zilun Hu , Jennifer Qiao
发明人: Donald J. P. Pinto , Wei Han , Zilun Hu , Jennifer Qiao
IPC分类号: C07D405/10 , C07D471/04 , A61K31/423 , A61P7/02
CPC分类号: C07D213/75 , A61K31/423 , C07D209/30 , C07D209/42 , C07D213/81 , C07D295/15 , C07D333/38 , C07D401/04 , C07D413/04 , C07D413/14 , C07D471/04
摘要: The present application describes glycinamidic compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
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