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1.NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF 有权
标题翻译: 萘磺隆化合物展示丙烯酸羟化酶抑制活性,组合物及其用途公开(公告)号:US20100048572A1
公开(公告)日:2010-02-25
申请号:US12612465
申请日:2009-11-04
申请人: Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
发明人: Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
IPC分类号: A61K31/535 , A61K31/435 , A61K31/438 , A61K31/35 , A61K31/34 , A61K31/195
CPC分类号: C07C255/47 , C07B2200/07 , C07C59/90 , C07C235/82 , C07C237/24 , C07C255/57 , C07C323/62 , C07C2602/10 , C07C2603/94 , C07D213/56 , C07D213/61 , C07D215/48 , C07D217/02 , C07D221/20 , C07D295/13 , C07D307/94 , C07D311/96
摘要: Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
摘要翻译: 式I和式II的化合物可用作HIF脯氨酰羟化酶的抑制剂。 式I和式II的化合物具有以下结构:其中本文提供变量的定义。
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2.Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof 有权
标题翻译: 显示脯氨酰羟化酶抑制活性的萘环酮化合物,组合物和用途公开(公告)号:US07928139B2
公开(公告)日:2011-04-19
申请号:US12612465
申请日:2009-11-04
申请人: Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
发明人: Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
IPC分类号: A61K31/352 , A61K31/195
CPC分类号: C07C255/47 , C07B2200/07 , C07C59/90 , C07C235/82 , C07C237/24 , C07C255/57 , C07C323/62 , C07C2602/10 , C07C2603/94 , C07D213/56 , C07D213/61 , C07D215/48 , C07D217/02 , C07D221/20 , C07D295/13 , C07D307/94 , C07D311/96
摘要: Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
摘要翻译: 式I和式II的化合物可用作HIF脯氨酰羟化酶的抑制剂。 式I和式II的化合物具有以下结构:其中本文提供变量的定义。
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3.Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof 有权
标题翻译: 显示脯氨酰羟化酶抑制活性的萘环酮化合物,组合物和用途公开(公告)号:US07635715B2
公开(公告)日:2009-12-22
申请号:US12002537
申请日:2007-12-17
申请人: Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
发明人: Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
IPC分类号: A61K31/352 , C07D311/96
CPC分类号: C07C255/47 , C07B2200/07 , C07C59/90 , C07C235/82 , C07C237/24 , C07C255/57 , C07C323/62 , C07C2602/10 , C07C2603/94 , C07D213/56 , C07D213/61 , C07D215/48 , C07D217/02 , C07D221/20 , C07D295/13 , C07D307/94 , C07D311/96
摘要: Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
摘要翻译: 式I和式II的化合物可用作HIF脯氨酰羟化酶的抑制剂。 式I和式II的化合物具有以下结构:其中本文提供变量的定义。
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公开(公告)号:US20090093483A1
公开(公告)日:2009-04-09
申请号:US12002537
申请日:2007-12-17
申请人: Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
发明人: Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
IPC分类号: A61K31/5375 , C07D265/30 , A61K31/352 , C07D311/96 , C07C229/34 , A61K31/197 , A61K31/4418 , C07D213/56 , A61P9/10 , C12N5/06
CPC分类号: C07C255/47 , C07B2200/07 , C07C59/90 , C07C235/82 , C07C237/24 , C07C255/57 , C07C323/62 , C07C2602/10 , C07C2603/94 , C07D213/56 , C07D213/61 , C07D215/48 , C07D217/02 , C07D221/20 , C07D295/13 , C07D307/94 , C07D311/96
摘要: Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
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5.Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof 有权
标题翻译: 显示脯氨酰羟化酶抑制活性的氮卓喹酮基化合物及其用途公开(公告)号:US08048892B2
公开(公告)日:2011-11-01
申请号:US12002538
申请日:2007-12-17
申请人: Jennifer R. Allen , Kaustav Biswas , Guo-Qiang Cao , Jennifer E. Golden , Stephanie Mercede , Tanya Peterkin , Anthony Reed , Christopher M. Tegley
发明人: Jennifer R. Allen , Kaustav Biswas , Guo-Qiang Cao , Jennifer E. Golden , Stephanie Mercede , Tanya Peterkin , Anthony Reed , Christopher M. Tegley
IPC分类号: A61K31/4375 , C07D471/04
CPC分类号: C07D471/04
摘要: are useful as inhibitors of HIF prolyl hydroxylases where the definitions of the variables are provided herein.
摘要翻译: 可用作HIF脯氨酰羟化酶的抑制剂,其中本文提供变量的定义。
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6.Azaquinolone based compounds exhibiting prolyl hydroxylase Inhibitory activity, compositions, and uses thereof 有权
标题翻译: 显示脯氨酰羟化酶抑制活性的组合物及其用途的基于喹唑酮酮的化合物公开(公告)号:US20090111806A1
公开(公告)日:2009-04-30
申请号:US12002538
申请日:2007-12-17
申请人: Jennifer R. Allen , Kaustav Biswas , Guo-Qiang Cao , Jennifer E. Golden , Stephanie Mercede , Tanya Peterkin , Anthony Reed , Christopher M. Tegley
发明人: Jennifer R. Allen , Kaustav Biswas , Guo-Qiang Cao , Jennifer E. Golden , Stephanie Mercede , Tanya Peterkin , Anthony Reed , Christopher M. Tegley
IPC分类号: A61K31/4375 , C07D471/04 , A61K31/5377 , A61P7/06 , A61P37/00 , A61P9/10 , A61P9/12 , A61P29/00 , C07D413/10
CPC分类号: C07D471/04
摘要: are useful as inhibitors of HIF prolyl hydroxylases where the definitions of the variables are provided herein.
摘要翻译: 可用作HIF脯氨酰羟化酶的抑制剂,其中本文提供变量的定义。
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7.Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof 有权
标题翻译: 具有脯氨酰羟化酶抑制活性的喹诺酮类化合物及其组合物及其用途公开(公告)号:US20070249605A1
公开(公告)日:2007-10-25
申请号:US11635683
申请日:2006-12-08
申请人: Jennifer Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael Frohn , Jennifer Golden , Randall Hungate , Robert Kurzeja , Stephanie Mercede , Kristine Muller , Susana Neira , Tanya Peterkin , Christopher Tegley , Violeta Yu
发明人: Jennifer Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael Frohn , Jennifer Golden , Randall Hungate , Robert Kurzeja , Stephanie Mercede , Kristine Muller , Susana Neira , Tanya Peterkin , Christopher Tegley , Violeta Yu
IPC分类号: A61K31/47 , A61K31/495 , A61K31/506 , A61K31/5377 , A61P35/00 , A61P5/00 , A61P7/00 , A61P9/00 , C07D215/00 , C07D237/02 , C07D239/02 , C07D265/30 , G01N33/53
CPC分类号: C07D215/22 , C07D215/56 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , G01N33/542
摘要: This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.
摘要翻译: 本发明涉及显示脯氨酰羟化酶抑制活性的新型喹诺酮类化合物。 本发明还涉及通过向受试者施用至少一种基于喹诺酮的化合物来增加受试者中HIF水平或活性或治疗与受试者中HIF水平或活性相关的病症的方法。 本发明还涉及用于检测HIF分子中的羟脯氨酸残基的测定法。
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8.
公开(公告)号:US20060025400A1
公开(公告)日:2006-02-02
申请号:US11182216
申请日:2005-07-15
申请人: Benny Askew , Toshihiro Aya , Kaustav Biswas , Guolin Cai , Jian Chen , Nianhe Han , Qingyian Liu , Thomas Nguyen , Nobuko Nishimura , Rana Nomak , Tanya Peterkin , Wenyuan Qian , Kevin Yang , Chester Yuan , Jiawang Zhu , Derin D' Amico , Jason Human , Qi Huang
发明人: Benny Askew , Toshihiro Aya , Kaustav Biswas , Guolin Cai , Jian Chen , Nianhe Han , Qingyian Liu , Thomas Nguyen , Nobuko Nishimura , Rana Nomak , Tanya Peterkin , Wenyuan Qian , Kevin Yang , Chester Yuan , Jiawang Zhu , Derin D' Amico , Jason Human , Qi Huang
IPC分类号: A61K31/55 , A61K31/497 , C07D403/02
CPC分类号: C07D221/10 , C07D221/08 , C07D239/74 , C07D241/08 , C07D243/08 , C07D249/08 , C07D295/135 , C07D311/96 , C07D335/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D491/04
摘要: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物,类似物,前药和其药学上可接受的衍生物,用于预防和治疗疾病和其它疾病或涉及疼痛,炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US20090054460A1
公开(公告)日:2009-02-26
申请号:US12008696
申请日:2008-01-11
申请人: Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
发明人: Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
IPC分类号: A61K31/495 , C07D241/04
CPC分类号: C07D241/08 , C07D243/08 , C07D245/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14
摘要: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物,类似物,前药和其药学上可接受的衍生物,用于预防和治疗疾病和其它疾病或涉及疼痛,炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US20050014749A1
公开(公告)日:2005-01-20
申请号:US10874086
申请日:2004-06-21
申请人: Jian Chen , Ben Askew , Kaustav Biswas , Jennifer Chau , Derin D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Yuan , Nianhe Han , Rana Nomak , Kevin Yang
发明人: Jian Chen , Ben Askew , Kaustav Biswas , Jennifer Chau , Derin D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Yuan , Nianhe Han , Rana Nomak , Kevin Yang
IPC分类号: A61K31/495 , C07D241/00 , C07D241/08 , C07D243/08 , C07D245/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D279/12 , A61K31/537 , A61K31/54
CPC分类号: C07D241/08 , C07D243/08 , C07D245/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14
摘要: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物,类似物,前药和药学上可接受的衍生物,用于预防和治疗疾病和其它疾病或涉及疼痛,炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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