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公开(公告)号:US08580828B2
公开(公告)日:2013-11-12
申请号:US13586355
申请日:2012-08-15
申请人: Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtil
发明人: Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtil
IPC分类号: A61K31/41 , C07D417/04
CPC分类号: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
摘要: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号:US08268871B2
公开(公告)日:2012-09-18
申请号:US12822066
申请日:2010-06-23
申请人: Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
发明人: Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
IPC分类号: A61K31/41 , C07D417/04
CPC分类号: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
摘要: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
摘要翻译: 本发明涉及有丝分裂驱动蛋白抑制剂,特别是KSP,以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号:US20130109656A1
公开(公告)日:2013-05-02
申请号:US13586355
申请日:2012-08-15
申请人: Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
发明人: Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
IPC分类号: C07F9/6539 , C07D419/04 , C07D513/04 , C07D417/04
CPC分类号: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
摘要: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号:US07795282B2
公开(公告)日:2010-09-14
申请号:US11415455
申请日:2006-05-01
申请人: Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
发明人: Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
IPC分类号: A61K31/41 , C07D285/14
CPC分类号: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
摘要: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
摘要翻译: 本发明涉及有丝分裂驱动蛋白抑制剂,特别是KSP,以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号:US20100331283A1
公开(公告)日:2010-12-30
申请号:US12822066
申请日:2010-06-23
申请人: Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robisnson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtti
发明人: Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robisnson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtti
IPC分类号: A61K31/675 , C07D417/04 , C07D513/04 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07F9/06 , C07D417/14 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/5355 , A61K31/542 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/454 , A61P35/00 , A61P31/10 , A61P37/00 , A61P29/00 , A61P9/00
CPC分类号: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
摘要: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号:US20120101103A1
公开(公告)日:2012-04-26
申请号:US13141675
申请日:2009-12-18
申请人: Adam Cook , Kevin W. Hunt , Robert Kirk Delisle , Todd Romoff , Christopher T. Clark , Ganghyeok Kim , Christopher P. Corrette , George A. Doherty , Laurence E. Burgess
发明人: Adam Cook , Kevin W. Hunt , Robert Kirk Delisle , Todd Romoff , Christopher T. Clark , Ganghyeok Kim , Christopher P. Corrette , George A. Doherty , Laurence E. Burgess
IPC分类号: A61K31/498 , A61K31/497 , A61K31/506 , A61K31/4709 , A61K31/453 , A61K31/444 , A61K31/4433 , A61K31/433 , A61K31/427 , A61K31/428 , A61K31/423 , A61K31/4155 , A61K31/4025 , C07D405/14 , C07D405/12 , C07D417/12 , A61K31/501
CPC分类号: C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12
摘要: Compounds of Formula I: (I) in which A, A1, R1, R7a, R7b, R8 and R10 have the meanings given in the specification, are DP2 receptor inhibitors useful in the treatment of useful in the treatment and prevention of immunologic diseases, allergic diseases such as asthma, allergic rhinitis and atopic dermatitis, and other inflammatory diseases mediated by prostaglandin D2 (PGD2). The compounds of Formula I may also be useful in treating diseases or medical conditions involving the Th2 T cell via production of IL-4, IL-5 and/or IL-13.
摘要翻译: 其中A,A1,R1,R7a,R7b,R8和R10具有本说明书中给出的含义的式I化合物:(I)是可用于治疗和预防免疫疾病的DP2受体抑制剂, 过敏性疾病如哮喘,过敏性鼻炎和特应性皮炎,以及由前列腺素D2(PGD2)介导的其他炎性疾病。 式I化合物还可用于通过产生IL-4,IL-5和/或IL-13来治疗涉及Th2T细胞的疾病或医学病症。
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公开(公告)号:US20110105463A1
公开(公告)日:2011-05-05
申请号:US13001201
申请日:2009-06-24
申请人: Laurence E. Burgess , Christopher T. Clark , Adam Cook , Christopher P. Corrette , Robert Kirk DeLisle , George A. Doherty , Kevin W. Hunt , Todd T. Romoff
发明人: Laurence E. Burgess , Christopher T. Clark , Adam Cook , Christopher P. Corrette , Robert Kirk DeLisle , George A. Doherty , Kevin W. Hunt , Todd T. Romoff
IPC分类号: A61K31/397 , C07D311/02 , A61K31/352 , C07D405/12 , A61K31/4025 , C07D403/12 , A61K31/453 , A61K31/506 , A61K31/4725 , A61P37/00
CPC分类号: C07D311/58 , C07D311/04 , C07D405/12 , C07D407/12
摘要: Compounds of Formula (I): in which A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.
摘要翻译: 式(I)化合物:其中A1,A2,W,L,G,R7a,R7b,R8,R9和R10具有本说明书中给出的含义,是可用于治疗免疫疾病的DP2受体调节剂。
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公开(公告)号:US08785445B2
公开(公告)日:2014-07-22
申请号:US13141675
申请日:2009-12-18
申请人: Adam Cook , Kevin W. Hunt , Robert Kirk Delisle , Todd Romoff , Christopher T. Clark , Ganghyeok Kim , Christopher P. Corrette , George A. Doherty , Laurence E. Burgess
发明人: Adam Cook , Kevin W. Hunt , Robert Kirk Delisle , Todd Romoff , Christopher T. Clark , Ganghyeok Kim , Christopher P. Corrette , George A. Doherty , Laurence E. Burgess
IPC分类号: C07D405/12 , A61K31/4433 , C07D241/20 , A61K31/497 , A61K31/501 , A61P11/06 , A61P27/14 , A61P17/00 , A61P29/00
CPC分类号: C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12
摘要: Compounds of Formula I: (I) in which A, A1, R1, R7a, R7b, R8 and R10 have the meanings given in the specification, are DP2 receptor inhibitors useful in the treatment of useful in the treatment and prevention of immunologic diseases, allergic diseases such as asthma, allergic rhinitis and atopic dermatitis, and other inflammatory diseases mediated by prostaglandin D2 (PGD2). The compounds of Formula I may also be useful in treating diseases or medical conditions involving the Th2 T cell via production of IL-4, IL-5 and/or IL-13.
摘要翻译: 其中A,A1,R1,R7a,R7b,R8和R10具有本说明书中给出的含义的式I化合物:(I)是可用于治疗和预防免疫疾病的DP2受体抑制剂, 过敏性疾病如哮喘,过敏性鼻炎和特应性皮炎,以及由前列腺素D2(PGD2)介导的其他炎性疾病。 式I化合物还可用于通过产生IL-4,IL-5和/或IL-13来治疗涉及Th2T细胞的疾病或医学病症。
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公开(公告)号:US08569522B2
公开(公告)日:2013-10-29
申请号:US13001201
申请日:2009-06-24
申请人: Laurence E. Burgess , Christopher T. Clark , Adam Cook , Christopher P. Corrette , Robert Kirk DeLisle , George A. Doherty , Kevin W. Hunt , Todd T. Romoff
发明人: Laurence E. Burgess , Christopher T. Clark , Adam Cook , Christopher P. Corrette , Robert Kirk DeLisle , George A. Doherty , Kevin W. Hunt , Todd T. Romoff
IPC分类号: C07D311/58 , A61K31/353
CPC分类号: C07D311/58 , C07D311/04 , C07D405/12 , C07D407/12
摘要: Compounds of Formula (I): in which A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.
摘要翻译: 式(I)化合物:其中A1,A2,W,L,G,R7a,R7b,R8,R9和R10具有本说明书中给出的含义,是可用于治疗免疫疾病的DP2受体调节剂。
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