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公开(公告)号:US20060287309A1
公开(公告)日:2006-12-21
申请号:US11466822
申请日:2006-08-24
申请人: Jerry Clark , Jamie Davis , David Favor , Lorraine Fay , Lloyd Franklin , Kevin Henegar , Douglas Johnson , Brian Nichelson , Ligong Ou , Joseph Repine , Michael Walters , Andrew White , Zhijian Zhu
发明人: Jerry Clark , Jamie Davis , David Favor , Lorraine Fay , Lloyd Franklin , Kevin Henegar , Douglas Johnson , Brian Nichelson , Ligong Ou , Joseph Repine , Michael Walters , Andrew White , Zhijian Zhu
IPC分类号: A61K31/5383 , A61K31/519 , A61K31/525 , A61K31/496 , A61K31/4745 , C07D491/02 , C07D487/02
CPC分类号: C07D471/04
摘要: This invention relates to compounds of the formula 1 wherein G, D, A, Z, Q, X, Y, R1, and R4 through R7 are defined as in the specification, processes for preparing the same and intermediates used in making the same, and pharmaceutical compositions containing such compounds and their use in the treatment of central nervous system disorders and other disorders.
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2.[1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA 审中-公开
标题翻译: [1,8]萘啶-2-酮及相关化合物治疗苦参碱公开(公告)号:US20060287310A1
公开(公告)日:2006-12-21
申请号:US11466828
申请日:2006-08-24
申请人: Jerry Clark , Jamie Davis , David Favor , Lorraine Fay , Lloyd Franklin , Kevin Henegar , Douglas Johnson , Brian Nichelson , Ligong Ou , Joseph Repine , Michael Walters , Andrew White , Zhijian Zhu
发明人: Jerry Clark , Jamie Davis , David Favor , Lorraine Fay , Lloyd Franklin , Kevin Henegar , Douglas Johnson , Brian Nichelson , Ligong Ou , Joseph Repine , Michael Walters , Andrew White , Zhijian Zhu
IPC分类号: A61K31/5383 , A61K31/519 , A61K31/496 , A61K31/4745 , C07D471/02 , C07D491/02 , C07D487/02
CPC分类号: C07D471/04
摘要: This invention relates to compounds of the formula 1 wherein G, D, A, Z, Q, X, Y, R1, and R4 through R7 are defined as in the specification, processes for preparing the same and intermediates used in making the same, and pharmaceutical compositions containing such compounds and their use in the treatment of central nervous system disorders and other disorders.
摘要翻译: 本发明涉及式1的化合物,其中G,D,A,Z,Q,X,Y,R 1和R 4至R 7 在说明书中定义,其制备方法和用于制备其的中间体,以及含有这些化合物的药物组合物及其在治疗中枢神经系统疾病和其它疾病中的用途。
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3.[1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia 失效
标题翻译: [1,8]萘啶-2-酮和相关化合物用于治疗精神分裂症公开(公告)号:US20050043309A1
公开(公告)日:2005-02-24
申请号:US10900210
申请日:2004-07-28
申请人: Jerry Clark , Jamie Davis , David Favor , Lorraine Fay , Lloyd Franklin , Kevin Henegar , Douglas Johnson , Brian Nichelson , Ligong Ou , Joseph Repine , Michael Walters , Andrew White , Zhijian Zhu
发明人: Jerry Clark , Jamie Davis , David Favor , Lorraine Fay , Lloyd Franklin , Kevin Henegar , Douglas Johnson , Brian Nichelson , Ligong Ou , Joseph Repine , Michael Walters , Andrew White , Zhijian Zhu
IPC分类号: A61P25/18 , C07D471/04 , C07D498/04 , A61K31/525 , A61K31/519 , C07D487/02
CPC分类号: C07D471/04
摘要: This invention relates to compounds of the formula 1 wherein G, D, A, Z, Q, X, Y, R1, and R4 through R7 are defined as in the specification, processes for preparing the same and intermediates used in making the same, and pharmaceutical compositions containing such compounds and their use in the treatment of central nervous system disorders and other disorders.
摘要翻译: 本发明涉及式1的化合物,其中G,D,A,Z,Q,X,Y,R 1和R 4至R 7如本说明书中所定义, 用于制造相同物质的中间体以及含有这些化合物的药物组合物及其在治疗中枢神经系统疾病和其它疾病中的用途。
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4.Preparation of gamma-amino acids having affinity for the alpha-2-delta protein 审中-公开
标题翻译: 制备对α-2-δ蛋白具有亲和性的γ-氨基酸公开(公告)号:US20070141684A1
公开(公告)日:2007-06-21
申请号:US11636304
申请日:2006-12-08
申请人: Margaret Evans , Lloyd Franklin , Lorraine Murtagh , Thomas Nanninga , Bruce Pearlman , James Saenz , Niamh Willis
发明人: Margaret Evans , Lloyd Franklin , Lorraine Murtagh , Thomas Nanninga , Bruce Pearlman , James Saenz , Niamh Willis
IPC分类号: C12P13/00 , C07C255/17
CPC分类号: C07C227/32 , C07C227/06 , C07C229/08 , C07C253/30 , C07C255/19 , C12P13/002 , C12P13/005 , C12P41/005 , Y02P20/582
摘要: Disclosed are materials and methods for preparing optically active γ-amino acids of Formula 1, which bind to the alpha-2-delta (α2δ) subunit of a calcium channel.
摘要翻译: 公开了用于制备式1的光学活性γ-氨基酸的材料和方法,其结合钙通道的α-2-δ(α2delta)亚基。
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公开(公告)号:US08293752B2
公开(公告)日:2012-10-23
申请号:US12164762
申请日:2008-06-30
申请人: Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
发明人: Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
IPC分类号: A61K31/535 , A61K31/52 , C07D239/42 , C07D413/14 , C07D401/14
CPC分类号: C07D417/14 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07F9/65583
摘要: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译: 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物,以及Raf介导的疾病的治疗方法。
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公开(公告)号:US20090036419A1
公开(公告)日:2009-02-05
申请号:US12164762
申请日:2008-06-30
申请人: Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
发明人: Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
IPC分类号: A61K31/397 , C07D239/24 , A61K31/505 , C07D295/00 , C07D473/00 , C12N9/99 , A61P9/00 , A61P37/02 , A61P31/12 , A61P19/08 , A61P29/00 , A61P25/00 , A61P35/00 , A61K31/52 , A61K31/5377 , A61K31/496 , A61K31/502
CPC分类号: C07D417/14 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07F9/65583
摘要: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译: 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物,以及Raf介导的疾病的治疗方法。
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